A0A8R2A3H7 · A0A8R2A3H7_ACYPI
- ProteinADAM10 endopeptidase
- Gene100163716
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1154 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
Cofactor
Features
Showing features for binding site, active site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | metal ion binding | |
Molecular Function | metalloendopeptidase activity | |
Biological Process | membrane protein ectodomain proteolysis | |
Biological Process | Notch signaling pathway |
Keywords
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameADAM10 endopeptidase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Paraneoptera > Hemiptera > Sternorrhyncha > Aphidomorpha > Aphidoidea > Aphididae > Macrosiphini > Acyrthosiphon
Accessions
- Primary accessionA0A8R2A3H7
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass type I membrane protein
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 193-214 | Disordered | ||||
Sequence: AGGGCRSEAMRERRSADNGHAD | ||||||
Compositional bias | 198-213 | Basic and acidic residues | ||||
Sequence: RSEAMRERRSADNGHA | ||||||
Domain | 306-520 | Peptidase M12B | ||||
Sequence: TTCMLYLQADHLFYEKYGREETCIEVMTRHVQRVNAIYRNTDFNQDGKPDNISFMIKRVKVHSNPDPTYKFLGNYGVEKFLEIFSEEDYDAFCLAYMFTYRDFEMGTLGLAWTGDLKNAGGVCEKNGHYRGSLKSLNTGIVTLLNYGKHVPSAVSHVTLAHEIGHNFGSPHDPEICTPGGDDGNYIMFARATSGDKKNNNRFSPCSLSAINPVLN | ||||||
Domain | 535-631 | Disintegrin | ||||
Sequence: TSICGNGVVEPGEECDCGWEEDCKDACCFPQRRYSPPEEPPCRLTAKSVCSPSQGPCCTNDCNLKIGELCRNDNGCRDASYCNGMTPTCPASINKPN | ||||||
Region | 827-884 | Disordered | ||||
Sequence: VREKRNVNNNNSPAKKSRKNVATEEESTTETSSPKKVGPGAQKKERKTRRKKSKGVID | ||||||
Region | 925-955 | Disordered | ||||
Sequence: LRKSKSSPAGFANPPEPPRPVVKAQPKNKDN | ||||||
Region | 998-1051 | Disordered | ||||
Sequence: RANRARGGGGGATGAAKQQAKKQQVNNGGSSRVTPQEPKNASAAATATRLQPPE | ||||||
Compositional bias | 1014-1044 | Polar residues | ||||
Sequence: KQQAKKQQVNNGGSSRVTPQEPKNASAAATA | ||||||
Region | 1068-1154 | Disordered | ||||
Sequence: EHDGHQPIFPVAASPPNKQRKSFAGVDAKTDEAPRSKRNSVPQQSLQQPSTSGNSNLMRFPSTENKQQANNNCPAPSNNASSKDEKT | ||||||
Compositional bias | 1104-1148 | Polar residues | ||||
Sequence: KRNSVPQQSLQQPSTSGNSNLMRFPSTENKQQANNNCPAPSNNAS |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,154
- Mass (Da)126,939
- Last updated2022-10-12 v1
- ChecksumB2778884096B26EA
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 198-213 | Basic and acidic residues | ||||
Sequence: RSEAMRERRSADNGHA | ||||||
Compositional bias | 1014-1044 | Polar residues | ||||
Sequence: KQQAKKQQVNNGGSSRVTPQEPKNASAAATA | ||||||
Compositional bias | 1104-1148 | Polar residues | ||||
Sequence: KRNSVPQQSLQQPSTSGNSNLMRFPSTENKQQANNNCPAPSNNAS |
Keywords
- Technical term