A0A8R1W6Q8 · A0A8R1W6Q8_ACYPI
- ProteinOxidized purine nucleoside triphosphate hydrolase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids314 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Oxidized purine nucleoside triphosphate hydrolase which is a prominent sanitizer of the oxidized nucleotide pool. Catalyzes the hydrolysis of 2-oxo-dATP (2-hydroxy-dATP) into 2-oxo-dAMP. Has also a significant hydrolase activity toward 2-oxo-ATP, 8-oxo-dGTP and 8-oxo-dATP. Through the hydrolysis of oxidized purine nucleoside triphosphates, prevents their incorporation into DNA and the subsequent transversions A:T to C:G and G:C to T:A. Also catalyzes the hydrolysis of methylated purine nucleoside triphosphate preventing their integration into DNA. Through this antimutagenic activity protects cells from oxidative stress.
Catalytic activity
- 2-oxo-ATP + H2O = 2-oxo-AMP + diphosphate + H+This reaction proceeds in the forward direction.
- 8-oxo-dATP + H2O = 8-oxo-dAMP + diphosphate + H+This reaction proceeds in the forward direction.
- 8-oxo-dGTP + H2O = 8-oxo-dGMP + diphosphate + H+This reaction proceeds in the forward direction.
- N6-methyl-ATP + H2O = N6-methyl-AMP + diphosphate + H+This reaction proceeds in the forward direction.
- N6-methyl-dATP + H2O = N6-methyl-dAMP + diphosphate + H+This reaction proceeds in the forward direction.
- O6-methyl-dGTP + H2O = O6-methyl-dGMP + diphosphate + H+This reaction proceeds in the forward direction.
Cofactor
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity | |
Molecular Function | metal ion binding | |
Biological Process | DNA protection |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameOxidized purine nucleoside triphosphate hydrolase
- EC number
- Alternative names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Paraneoptera > Hemiptera > Sternorrhyncha > Aphidomorpha > Aphidoidea > Aphididae > Macrosiphini > Acyrthosiphon
Accessions
- Primary accessionA0A8R1W6Q8
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Subunit
Monomer.
Structure
Sequence
- Sequence statusComplete
- Length314
- Mass (Da)36,984
- Last updated2022-10-12 v1
- Checksum0B20082E5BDE830B
Keywords
- Technical term