A0A8Q3WKN1 · A0A8Q3WKN1_HUMAN

  • Protein
    Tyrosine-protein kinase
  • Gene
    BTK
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    2/5

Function

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Features

Showing features for binding site.

154450100150200250300350400450500
TypeIDPosition(s)Description
Binding site430ATP (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functionprotein tyrosine kinase activity
Biological Processadaptive immune response
Biological Processintracellular signal transduction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Tyrosine-protein kinase
  • EC number

Gene names

    • Name
      BTK

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A0A8Q3WKN1

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 526 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Genetic variation databases

PTM/Processing

Features

Showing features for modified residue (large scale data).

TypeIDPosition(s)SourceDescription
Modified residue (large scale data)21PRIDEPhosphoserine
Modified residue (large scale data)40PRIDEPhosphotyrosine
Modified residue (large scale data)55PRIDEPhosphoserine
Modified residue (large scale data)134PRIDEPhosphotyrosine
Modified residue (large scale data)184PRIDEPhosphothreonine
Modified residue (large scale data)191PRIDEPhosphothreonine
Modified residue (large scale data)223PRIDEPhosphotyrosine
Modified residue (large scale data)225PRIDEPhosphotyrosine
Modified residue (large scale data)323PRIDEPhosphoserine
Modified residue (large scale data)334PRIDEPhosphotyrosine
Modified residue (large scale data)344PRIDEPhosphotyrosine
Modified residue (large scale data)361PRIDEPhosphotyrosine
Modified residue (large scale data)366PRIDEPhosphoserine
Modified residue (large scale data)371PRIDEPhosphoserine
Modified residue (large scale data)375PRIDEPhosphotyrosine
Modified residue (large scale data)543PRIDEPhosphoserine

Keywords

Proteomic databases

Structure

3D structure databases

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain3-133PH
Region174-210Disordered
Domain214-274SH3
Domain281-377SH2
Domain402-544Protein kinase

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    544
  • Mass (Da)
    62,784
  • Last updated
    2022-10-12 v1
  • Checksum
    59D10143D873622F
MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSR

Computationally mapped potential isoform sequences

There are 17 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q06187BTK_HUMANBTK659
Q5JY90Q5JY90_HUMANBTK483
A0A8Q3WLZ5A0A8Q3WLZ5_HUMANBTK638
A0A8Q3WLR2A0A8Q3WLR2_HUMANBTK49
A0A8Q3WL62A0A8Q3WL62_HUMANBTK658
A0A8Q3WKS7A0A8Q3WKS7_HUMANBTK63
A0A8Q3WKM0A0A8Q3WKM0_HUMANBTK50
A0A8Q3WKR7A0A8Q3WKR7_HUMANBTK118
A0A8Q3SHZ6A0A8Q3SHZ6_HUMANBTK648
A0A8Q3SI35A0A8Q3SI35_HUMANBTK657
A0A8Q3SI44A0A8Q3SI44_HUMANBTK100
A0A8Q3SI38A0A8Q3SI38_HUMANBTK68
A0A8Q3SHX9A0A8Q3SHX9_HUMANBTK235
Q3MS88Q3MS88_HUMANBTK139
Q3MS90Q3MS90_HUMANBTK74
Q3MS94Q3MS94_HUMANBTK197
Q3MS97Q3MS97_HUMANBTK95

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL035422
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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