A0A8Q3SIH0 · A0A8Q3SIH0_HUMAN
- ProteinAdenosine deaminase
- GeneADA
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids386 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
Catalytic activity
- 2'-deoxyadenosine + H2O + H+ = 2'-deoxyinosine + NH4+This reaction proceeds in the forward direction.
Cofactor
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | anchoring junction | |
Cellular Component | cytoplasmic vesicle lumen | |
Cellular Component | plasma membrane | |
Molecular Function | adenosine deaminase activity | |
Biological Process | nucleotide metabolic process | |
Biological Process | purine ribonucleoside monophosphate biosynthetic process |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAdenosine deaminase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA0A8Q3SIH0
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Peripheral membrane protein
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 465 variants from UniProt as well as other sources including ClinVar and dbSNP.
Genetic variation databases
PTM/Processing
Features
Showing features for modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Modified residue (large scale data) | 29 | PRIDE | Phosphotyrosine | ||||
Sequence: Y | |||||||
Modified residue (large scale data) | 272 | PRIDE | Phosphotyrosine | ||||
Sequence: Y | |||||||
Modified residue (large scale data) | 371 | PRIDE | Phosphotyrosine | ||||
Sequence: Y |
Proteomic databases
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 10-203 | Adenosine deaminase | ||||
Sequence: PKVELHVHLDGSIKPETILYYGRRRGIALPANTAEGLLNVIGMDKPLTLPDFLAKFDYYMPAIAGCREAIKRIAYEFVEMKAKEGVVYVEVRYSPHLLANSKVEPIPWNQAEGDLTPDEVVALVGQGLQEGERDFGVKARSILCCMRHQPNWSPKVVELCKKYQQQTVVAIDLAGDETIPGSSLLPGHVQAYQH | ||||||
Domain | 219-372 | Adenosine deaminase | ||||
Sequence: TWLSPFQEAVKSGIHRTVHAGEVGSAEVVKEAVDILKTERLGHGYHTLEDQALYNRLRQENMHFEICPWSSYLTGAWKPDTEHAVIRLKNDQANYSLNTDDPLIFKSTLDTDYQMTKRDMGFTEEEFKRLNINAAKSSFLPEDEKRELLDLLYK |
Sequence similarities
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length386
- Mass (Da)43,268
- Last updated2022-10-12 v1
- Checksum1531BDD8F162AEB2
Computationally mapped potential isoform sequences
There are 35 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
P00813 | ADA_HUMAN | ADA | 363 | ||
A0A0S2Z3T6 | A0A0S2Z3T6_HUMAN | ADA | 188 | ||
A0A0S2Z3B9 | A0A0S2Z3B9_HUMAN | ADA | 209 | ||
A0A8Q3WM84 | A0A8Q3WM84_HUMAN | ADA | 399 | ||
A0A8Q3WM09 | A0A8Q3WM09_HUMAN | ADA | 361 | ||
A0A8Q3WM58 | A0A8Q3WM58_HUMAN | ADA | 130 | ||
A0A8Q3WLJ0 | A0A8Q3WLJ0_HUMAN | ADA | 137 | ||
A0A8Q3WLK2 | A0A8Q3WLK2_HUMAN | ADA | 178 | ||
A0A8Q3WKW4 | A0A8Q3WKW4_HUMAN | ADA | 125 | ||
A0A8Q3WKY2 | A0A8Q3WKY2_HUMAN | ADA | 417 | ||
A0A8Q3WKX5 | A0A8Q3WKX5_HUMAN | ADA | 119 | ||
A0A8Q3WKX8 | A0A8Q3WKX8_HUMAN | ADA | 239 | ||
A0A8Q3WKZ1 | A0A8Q3WKZ1_HUMAN | ADA | 441 | ||
A0A8Q3WKZ4 | A0A8Q3WKZ4_HUMAN | ADA | 388 | ||
A0A8Q3WKZ5 | A0A8Q3WKZ5_HUMAN | ADA | 338 | ||
A0A8Q3WKZ6 | A0A8Q3WKZ6_HUMAN | ADA | 312 | ||
A0A8Q3WKZ9 | A0A8Q3WKZ9_HUMAN | ADA | 384 | ||
A0A8Q3WL01 | A0A8Q3WL01_HUMAN | ADA | 362 | ||
A0A8Q3WL06 | A0A8Q3WL06_HUMAN | ADA | 204 | ||
A0A8Q3WL32 | A0A8Q3WL32_HUMAN | ADA | 48 | ||
A0A8Q3SIC0 | A0A8Q3SIC0_HUMAN | ADA | 388 | ||
A0A8Q3SIC7 | A0A8Q3SIC7_HUMAN | ADA | 387 | ||
A0A8Q3SJ25 | A0A8Q3SJ25_HUMAN | ADA | 156 | ||
A0A8Q3SIE4 | A0A8Q3SIE4_HUMAN | ADA | 53 | ||
A0A8Q3SIG8 | A0A8Q3SIG8_HUMAN | ADA | 400 | ||
A0A8Q3SIA9 | A0A8Q3SIA9_HUMAN | ADA | 386 | ||
A0A8Q3SI64 | A0A8Q3SI64_HUMAN | ADA | 233 | ||
A0A8Q3SI46 | A0A8Q3SI46_HUMAN | ADA | 389 | ||
A0A8Q3SI69 | A0A8Q3SI69_HUMAN | ADA | 254 | ||
A0A8Q3SJ50 | A0A8Q3SJ50_HUMAN | ADA | 235 | ||
A0A8Q3SJ57 | A0A8Q3SJ57_HUMAN | ADA | 83 | ||
A0A8Q3SJ63 | A0A8Q3SJ63_HUMAN | ADA | 362 | ||
F5GYD4 | F5GYD4_HUMAN | ADA | 75 | ||
F5GXW0 | F5GXW0_HUMAN | ADA | 263 | ||
F5GWI4 | F5GWI4_HUMAN | ADA | 339 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL139352 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
KF456921 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
Z97053 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |