A0A8Q3SIH0 · A0A8Q3SIH0_HUMAN

  • Protein
    Adenosine deaminase
  • Gene
    ADA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    2/5

Function

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentanchoring junction
Cellular Componentcytoplasmic vesicle lumen
Cellular Componentplasma membrane
Molecular Functionadenosine deaminase activity
Biological Processnucleotide metabolic process
Biological Processpurine ribonucleoside monophosphate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adenosine deaminase
  • EC number
  • Alternative names
    • Adenosine aminohydrolase

Gene names

    • Name
      ADA

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A0A8Q3SIH0

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Peripheral membrane protein
Cytoplasmic vesicle lumen

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 465 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Genetic variation databases

PTM/Processing

Features

Showing features for modified residue (large scale data).

TypeIDPosition(s)SourceDescription
Modified residue (large scale data)29PRIDEPhosphotyrosine
Modified residue (large scale data)272PRIDEPhosphotyrosine
Modified residue (large scale data)371PRIDEPhosphotyrosine

Proteomic databases

Structure

3D structure databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain10-203Adenosine deaminase
Domain219-372Adenosine deaminase

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    386
  • Mass (Da)
    43,268
  • Last updated
    2022-10-12 v1
  • Checksum
    1531BDD8F162AEB2
MAQTPAFDKPKVELHVHLDGSIKPETILYYGRRRGIALPANTAEGLLNVIGMDKPLTLPDFLAKFDYYMPAIAGCREAIKRIAYEFVEMKAKEGVVYVEVRYSPHLLANSKVEPIPWNQAEGDLTPDEVVALVGQGLQEGERDFGVKARSILCCMRHQPNWSPKVVELCKKYQQQTVVAIDLAGDETIPGSSLLPGHVQAYQHGQGRACRGPPARAPMTWLSPFQEAVKSGIHRTVHAGEVGSAEVVKEAVDILKTERLGHGYHTLEDQALYNRLRQENMHFEICPWSSYLTGAWKPDTEHAVIRLKNDQANYSLNTDDPLIFKSTLDTDYQMTKRDMGFTEEEFKRLNINAAKSSFLPEDEKRELLDLLYKAYGMPPSASAGQNL

Computationally mapped potential isoform sequences

There are 35 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
P00813ADA_HUMANADA363
A0A0S2Z3T6A0A0S2Z3T6_HUMANADA188
A0A0S2Z3B9A0A0S2Z3B9_HUMANADA209
A0A8Q3WM84A0A8Q3WM84_HUMANADA399
A0A8Q3WM09A0A8Q3WM09_HUMANADA361
A0A8Q3WM58A0A8Q3WM58_HUMANADA130
A0A8Q3WLJ0A0A8Q3WLJ0_HUMANADA137
A0A8Q3WLK2A0A8Q3WLK2_HUMANADA178
A0A8Q3WKW4A0A8Q3WKW4_HUMANADA125
A0A8Q3WKY2A0A8Q3WKY2_HUMANADA417
A0A8Q3WKX5A0A8Q3WKX5_HUMANADA119
A0A8Q3WKX8A0A8Q3WKX8_HUMANADA239
A0A8Q3WKZ1A0A8Q3WKZ1_HUMANADA441
A0A8Q3WKZ4A0A8Q3WKZ4_HUMANADA388
A0A8Q3WKZ5A0A8Q3WKZ5_HUMANADA338
A0A8Q3WKZ6A0A8Q3WKZ6_HUMANADA312
A0A8Q3WKZ9A0A8Q3WKZ9_HUMANADA384
A0A8Q3WL01A0A8Q3WL01_HUMANADA362
A0A8Q3WL06A0A8Q3WL06_HUMANADA204
A0A8Q3WL32A0A8Q3WL32_HUMANADA48
A0A8Q3SIC0A0A8Q3SIC0_HUMANADA388
A0A8Q3SIC7A0A8Q3SIC7_HUMANADA387
A0A8Q3SJ25A0A8Q3SJ25_HUMANADA156
A0A8Q3SIE4A0A8Q3SIE4_HUMANADA53
A0A8Q3SIG8A0A8Q3SIG8_HUMANADA400
A0A8Q3SIA9A0A8Q3SIA9_HUMANADA386
A0A8Q3SI64A0A8Q3SI64_HUMANADA233
A0A8Q3SI46A0A8Q3SI46_HUMANADA389
A0A8Q3SI69A0A8Q3SI69_HUMANADA254
A0A8Q3SJ50A0A8Q3SJ50_HUMANADA235
A0A8Q3SJ57A0A8Q3SJ57_HUMANADA83
A0A8Q3SJ63A0A8Q3SJ63_HUMANADA362
F5GYD4F5GYD4_HUMANADA75
F5GXW0F5GXW0_HUMANADA263
F5GWI4F5GWI4_HUMANADA339

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL139352
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
KF456921
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
Z97053
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp