A0A8P0SKJ6 · A0A8P0SKJ6_CANLF
- ProteinCoagulation factor XII
- GeneF12
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids611 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
function
Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa.
Catalytic activity
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 404 | Charge relay system | ||||
Sequence: H | ||||||
Active site | 453 | Charge relay system | ||||
Sequence: D | ||||||
Active site | 559 | Charge relay system | ||||
Sequence: S |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular space | |
Molecular Function | calcium ion binding | |
Molecular Function | serine-type endopeptidase activity | |
Biological Process | proteolysis |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCoagulation factor XII
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Caniformia > Canidae > Canis
Accessions
- Primary accessionA0A8P0SKJ6
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-19 | |||||
Sequence: MRLLLFLGSLLGSLESVLL | ||||||
Chain | PRO_5035948413 | 20-611 | Coagulation factor XII | |||
Sequence: TPPWKAPKVHNHRVDEHTVVLTVTGEPCYFPFQYNRQLYHKCTHRGRPGPQPWCATTPNFEQDQQWAYCLEPKKVKDHCSKHSPCQKGGTCVNMPDGPHCICPEHFTGKHCQREKCFEPQLLQFFHEKEIWHRLEPAGVAKCECRGPDVHCKLVASQGCHTNPCLNGGTCFQAETHRLCRCPTGYAGRFCDVDTEARCYHGRGLDYRGAADAALSGARCQRWASEASYQEVPAEQALSWGLGNHAFCRNPDNDTRPWCFVRSGDRLSWEYCRLARCQAPGLAIPQILPPTQVPSGRPTLPVPSPSALQKPQPPTPASSATREQPAAVPSSRCGQRLRKRLSSLSRVVGGLVALPGAHPYIAALYWRHSFCAGSLIASCWVLTAAHCLQDRPAPGELTVVLGQDRHNRSCEQCQTLAVRAYRLHESFSPVTYQHDLALLRLQETADGRCALPSPFVQPVCLPSGAARPAEAQAEAALCEVAGWGHLFEGAGEYSSFLQEAQVPLIPPQRCSAPEVHGASFIPGMLCAGFLEGGTDACQGDSGGPLVCEEEASERQLILRGIISWGSGCGDRYKPGVYTDVASYVTWIQEHTNS | ||||||
Disulfide bond | 47↔73 | |||||
Sequence: CYFPFQYNRQLYHKCTHRGRPGPQPWC | ||||||
Disulfide bond | 61↔88 | |||||
Sequence: CTHRGRPGPQPWCATTPNFEQDQQWAYC | ||||||
Disulfide bond | 121↔130 | |||||
Sequence: CPEHFTGKHC | ||||||
Disulfide bond | 200↔209 | |||||
Sequence: CPTGYAGRFC | ||||||
Disulfide bond | 238↔277 | |||||
Sequence: CQRWASEASYQEVPAEQALSWGLGNHAFCRNPDNDTRPWC |
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 42-90 | Fibronectin type-II | ||||
Sequence: VTGEPCYFPFQYNRQLYHKCTHRGRPGPQPWCATTPNFEQDQQWAYCLE | ||||||
Domain | 94-131 | EGF-like | ||||
Sequence: VKDHCSKHSPCQKGGTCVNMPDGPHCICPEHFTGKHCQ | ||||||
Domain | 174-210 | EGF-like | ||||
Sequence: ASQGCHTNPCLNGGTCFQAETHRLCRCPTGYAGRFCD | ||||||
Domain | 216-295 | Kringle | ||||
Sequence: RCYHGRGLDYRGAADAALSGARCQRWASEASYQEVPAEQALSWGLGNHAFCRNPDNDTRPWCFVRSGDRLSWEYCRLARC | ||||||
Region | 306-350 | Disordered | ||||
Sequence: LPPTQVPSGRPTLPVPSPSALQKPQPPTPASSATREQPAAVPSSR | ||||||
Compositional bias | 309-330 | Pro residues | ||||
Sequence: TQVPSGRPTLPVPSPSALQKPQ | ||||||
Compositional bias | 331-346 | Polar residues | ||||
Sequence: PPTPASSATREQPAAV | ||||||
Domain | 365-610 | Peptidase S1 | ||||
Sequence: VVGGLVALPGAHPYIAALYWRHSFCAGSLIASCWVLTAAHCLQDRPAPGELTVVLGQDRHNRSCEQCQTLAVRAYRLHESFSPVTYQHDLALLRLQETADGRCALPSPFVQPVCLPSGAARPAEAQAEAALCEVAGWGHLFEGAGEYSSFLQEAQVPLIPPQRCSAPEVHGASFIPGMLCAGFLEGGTDACQGDSGGPLVCEEEASERQLILRGIISWGSGCGDRYKPGVYTDVASYVTWIQEHTN |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length611
- Mass (Da)67,107
- Last updated2022-10-12 v1
- Checksum60AE953A46347608
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 309-330 | Pro residues | ||||
Sequence: TQVPSGRPTLPVPSPSALQKPQ | ||||||
Compositional bias | 331-346 | Polar residues | ||||
Sequence: PPTPASSATREQPAAV |