A0A8P0SDL0 · A0A8P0SDL0_CANLF

Function

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

1934100200300400500600700800900
Type
IDPosition(s)Description
Binding site213Zn2+ (UniProtKB | ChEBI); catalytic; in inhibited form
Binding site274Ca2+ 1 (UniProtKB | ChEBI)
Binding site274Ca2+ 2 (UniProtKB | ChEBI)
Binding site357Ca2+ 2 (UniProtKB | ChEBI)
Binding site357Ca2+ 1 (UniProtKB | ChEBI)
Binding site364Ca2+ 1 (UniProtKB | ChEBI)
Binding site414Zn2+ (UniProtKB | ChEBI); catalytic
Active site415
Binding site418Zn2+ (UniProtKB | ChEBI); catalytic
Binding site424Zn2+ (UniProtKB | ChEBI); catalytic
Binding site475Ca2+ 1 (UniProtKB | ChEBI)
Binding site478Ca2+ 1 (UniProtKB | ChEBI)
Binding site478Ca2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcollagen-containing extracellular matrix
Cellular Componentextracellular region
Molecular Functionmetalloendopeptidase activity
Molecular Functionzinc ion binding
Biological Processextracellular matrix organization
Biological Processproteolysis

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • ADAM metallopeptidase with thrombospondin type 1 motif 5

Gene names

    • Name
      ADAMTS5

Organism names

Accessions

  • Primary accession
    A0A8P0SDL0

Proteomes

Organism-specific databases

Subcellular Location

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation.

Type
IDPosition(s)Description
Signal1-20
ChainPRO_503993377021-934
Disulfide bond346↔398
Disulfide bond375↔380
Disulfide bond392↔475
Disulfide bond430↔459
Disulfide bond501↔523
Glycosylation502N-linked (GlcNAc...) asparagine
Disulfide bond512↔533
Disulfide bond518↔552
Disulfide bond546↔557
Disulfide bond583↔620
Disulfide bond587↔625
Disulfide bond598↔610
Glycosylation732N-linked (GlcNAc...) asparagine

Keywords

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region20-71Disordered
Region207-259Disordered
Compositional bias213-252Pro residues
Domain271-480Peptidase M12B

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    934
  • Mass (Da)
    101,775
  • Last updated
    2023-06-28 v1
  • Checksum
    3209D009F8AFEB92
MLLGWASLLLGALRLPPVAAGPAAAPAQDKAGQPWAAAAAAQPRRRQGEEAREPAEPPGHPHPLAPQRRSSGLVQNVDQIYAGGGKVGYLVYAGGRRFLLDLERDGSVGAAGSAPAGRGPGAPRRHRDHCFYRGTVDGSPRSLAVLDLCGGLDGFFAVRHARYTLKPLLRGPWAGAGAGAEAERVYGDGSPRILHVYTREGFSFEALPPRTSCETPASPPGPRERPPAHSSPDPRWSPAPPFPAPPAASPDGGPGPQTWWRRRRRSISRARQVELLLVADASMARMYGRGLQHYLLTLASIANRLYSHASIENHIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYDAAILFTREDLCGHHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHDDSKFCEENFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLPRKQILGPEELPGQTYDATQQCNLTFGPEYSVCPGMDVCARLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRICLQGKCVDKTKKKYYSTSSHGNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCNVTPCPPNGKSFRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVLLGDVCKLTCRAKGTGYYVVFSPKVTDGTECRPYSNSVCVRGKCVRTGCDGIIGSKLQYDKCAVCGGDNSSCTKVVGTFNKKSKGYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKKNGEYLINGKYMISTSETIIDINGTVMNYSGWSHRDDFLHGMGYSATKEILIVQILATDPTKALDVRYSFFVPKKSTQKVNSVTSHASNKVGSHTPQLQWVTGPWLACSRTCDTGWHTRTVQCQDANRKLAKGCLLSQRPSAFKQCLLKKC

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias213-252Pro residues

Genome annotation databases

Similar Proteins

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