A0A8P0PCS4 · A0A8P0PCS4_CANLF

Function

Catalytic activity

  • (2E)-hexadecenal + H2O + NAD+ = (E)-hexadec-2-enoate + 2 H+ + NADH
  • (2E,6E)-farnesal + H2O + NAD+ = (2E,6E)-farnesoate + 2 H+ + NADH
    EC:1.2.1.94 (UniProtKB | ENZYME | Rhea)
  • 2 H+ + hexadecanoate + NADH = H2O + hexadecanal + NAD+
  • 2,6,10,14-tetramethylpentadecanal + H2O + NAD+ = 2,6,10,14-tetramethylpentadecanoate + 2 H+ + NADH
  • 22-oxodocosanoate + H2O + NAD+ = docosanedioate + 2 H+ + NADH
  • H2O + NAD+ + octadecanal = 2 H+ + NADH + octadecanoate
  • H2O + NAD+ + octanal = 2 H+ + NADH + octanoate
  • H2O + NAD+ + tetradecanal = 2 H+ + NADH + tetradecanoate
  • H2O + heptanal + NAD+ = 2 H+ + heptanoate + NADH
  • a fatty aldehyde + H2O + NAD+ = a fatty acid + 2 H+ + NADH
  • an aldehyde + H2O + NAD+ = a carboxylate + 2 H+ + NADH
    EC:1.2.1.3 (UniProtKB | ENZYME | Rhea)
  • decanal + H2O + NAD+ = decanoate + 2 H+ + NADH
  • dodecanoate + 2 H+ + NADH = dodecanal + H2O + NAD+

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site970

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functionantiporter activity
Molecular Functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
Molecular Functionxenobiotic transmembrane transporter activity
Biological Processcellular aldehyde metabolic process
Biological Processfatty acid metabolic process
Biological Processxenobiotic detoxification by transmembrane export across the plasma membrane

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Multidrug and toxin extrusion protein

Gene names

    • Name
      ALDH3A2
    • Synonyms
      LOC119881481

Organism names

Accessions

  • Primary accession
    A0A8P0PCS4

Proteomes

Organism-specific databases

Subcellular Location

Endoplasmic reticulum membrane
; Single-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane290-311Helical
Transmembrane317-339Helical
Transmembrane359-378Helical
Transmembrane398-415Helical
Transmembrane427-453Helical
Transmembrane459-481Helical
Transmembrane541-562Helical
Transmembrane583-609Helical
Transmembrane653-674Helical
Transmembrane680-702Helical
Transmembrane1227-1247Helical

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region1-54Disordered
Compositional bias16-30Pro residues
Compositional bias31-46Polar residues
Region87-279Disordered
Compositional bias183-204Basic residues
Compositional bias246-270Pro residues
Domain764-1184Aldehyde dehydrogenase

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,248
  • Mass (Da)
    135,617
  • Last updated
    2022-10-12 v1
  • Checksum
    7BF14294A818093D
MGDGDAEGLSLGPHCRPRSAPPPPPPASAGNTFCNTPVTRGRGSGHLKSQQRAPAVGGWNYEFALSTPPPPAQFTLTTSLLCHRRATSHSLDRVRYPPPPPDCDPSPTTSSGVPRPAPNSWGSADGDGWQGASWVRRRDPPASPTSASSPPPPAAGGAGRVGRGGAGPGRPQLTAASRAQSPRRHGGPRRRSRRPRRPRRPGQHPVARRPPLARLPAGPAGRAAARRATRGGRAGGARGPRGECAAPRPRRPPPPPRPRAPAPPAPPRSRSLPGGRLGVSSRSPALAPQFLAQLMIFLIGVVSSIFCGHLGKVELDAVTLAVSVVNVTGISVGTGLASACDTLMSQSFGGKNLKRVGIILQRGILILMLCCFPCWAIFINTERILLLLKQDPEVSRIAQIYVMIFIPALPAAFLFQLQTRYLQSQGIIMPQVITGIAANVINVGMNALLLYALDLGVVGSAWANTTSQFLLSALLFLYVWWRKLHVDTWGGWTRDCFQEWNSYIQLAIPSMFMVCIEWWTFEIGTFLAGLISVTELGAQAIIYELASAAYMVPLGFGVAASVRVGNALGAGNAEQAWHSSVTVLLCAGVCALVVGVLLAALKDVVAYIFTSDKDIIYLVSQVMPIFAPFHLFDALAGTCGGVLRGTGKQKIGAILNAIGYYVFGFPIGVSLMFAAKLGIIGLWSGLIVCVFFQALFYLVLIWKTNWERVAEQAQVRAGLKGIIRETTPSPADLPVLEKEVTDGVILPDIITPESQTLQLMDRAMESRIQRVRAAFASGRSRPVRFRLQQLEALRRMVQEREKDILEAIAGDLCKSELNAYSQEVITVLGELDLVLENLPEWVAAKPAKKNLLTMLDEAYVQPEPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSEKTAKILAELLPRYLDQDLYVVINGGVEETTELLKQRFDHILYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYVDKDCDLDIACRRITWGKYMNCGQTCIAPDYVLCEPSLQNQIVQKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGGETDEATRYIAPTILSDVDPESRVMQEEIFGPILPIVPVKNADEAIKFINSREKPLAFYIFSHNDKLVRQMINGTSSGGVTANDVIMHFTLSSLPFGGVGSSGMGAYHGKYSFDTFSHQRPCLLKSLKREGANKLRYPPNSQSKVDWAKFFILKRFNKGKLSLLVLTFLGILAAVLVKVGYY

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias16-30Pro residues
Compositional bias31-46Polar residues
Compositional bias183-204Basic residues
Compositional bias246-270Pro residues

Genome annotation databases

Similar Proteins

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