A0A8P0P691 · A0A8P0P691_CANLF
- ProteinAldo-keto reductase family 1 member A1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids325 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- 3-deoxyfructose + NADP+ = 3-deoxyglucosone + NADPH + H+
- S-nitroso-CoA + NADPH + H+ = sulfinamide-CoA + NADP+This reaction proceeds in the forward direction.
- S-nitrosoglutathione + NADPH + H+ = S-(hydroxysulfenamide)glutathione + NADP+
- hydroxyacetone + NADP+ = methylglyoxal + NADPH + H+
Features
Showing features for active site, site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 50 | Proton donor | |||
Site | 80 | Lowers pKa of active site Tyr | |||
Binding site | 113 | substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | apical plasma membrane | |
Cellular Component | cytosol | |
Molecular Function | alcohol dehydrogenase (NADP+) activity | |
Biological Process | aldehyde catabolic process |
Keywords
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAldo-keto reductase family 1 member A1
- EC number
- Alternative names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Carnivora > Caniformia > Canidae > Canis
Accessions
- Primary accessionA0A8P0P691
Proteomes
Subcellular Location
Structure
Sequence
- Sequence statusComplete
- Length325
- Mass (Da)36,605
- Last updated2022-10-12 v1
- Checksum8A98E7175CA38C61