A0A8M9QKA6 · A0A8M9QKA6_DANRE
- ProteinHECT-type E3 ubiquitin transferase
- Genehecw1b
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1544 (go to sequence)
- Protein existencePredicted
- Annotation score2/5
Function
Catalytic activity
Pathway
Protein modification; protein ubiquitination.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 1512 | Glycyl thioester intermediate | ||||
Sequence: C |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ubiquitin protein ligase activity | |
Biological Process | protein ubiquitination | |
Biological Process | regulation of dendrite morphogenesis | |
Biological Process | ubiquitin-dependent protein catabolic process |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHECT-type E3 ubiquitin transferase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionA0A8M9QKA6
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 190-326 | C2 | ||||
Sequence: PSAPVFKPVATDDVPQSQGRRRLISFSLSDFQATGLKKGMFFNPDPYLKIAIHPGKHSIFPALPHHGQEKRSGIVCNTINPVWQRERFNFVSLPTDVLEIEVKDKFAKSRPIIKRFLGKLSMPVQRLLEKHAIGDRV | ||||||
Region | 355-381 | Disordered | ||||
Sequence: HPDDEDMSLSTEQPVAAAEAQAQPQAE | ||||||
Region | 425-505 | Disordered | ||||
Sequence: CLEEEQQEGEAAAAAAAMEQSETNAEETTQVLDPINGAEEEEAENNCAFAEESSDARAGEEDEAISDPQPASEEPDADLEE | ||||||
Compositional bias | 490-504 | Acidic residues | ||||
Sequence: SDPQPASEEPDADLE | ||||||
Region | 558-725 | Disordered | ||||
Sequence: PATQPQTGDSAGPEPDRPMGVEEEDEEEEEEGVTLEDHALTPNGPRRTLPRSRSHERLSDLIQMLDGDGHPLGAEGQTGNQRSPDLSPVACCSHMSPRASGPIRAQSLDSARRSESTVFSSQDDEDEMEQPNGILGSETETEQGAQCREPGDGSCQWEEAPDSHVQSP | ||||||
Compositional bias | 576-591 | Acidic residues | ||||
Sequence: MGVEEEDEEEEEEGVT | ||||||
Compositional bias | 606-620 | Basic and acidic residues | ||||
Sequence: LPRSRSHERLSDLIQ | ||||||
Domain | 759-792 | WW | ||||
Sequence: EPLPPNWEARIDSHGRVFYVDHINRTTTWQRPTS | ||||||
Compositional bias | 820-836 | Basic and acidic residues | ||||
Sequence: RTMATERREEESGSPRN | ||||||
Region | 820-860 | Disordered | ||||
Sequence: RTMATERREEESGSPRNDRTANTETDSPLQTNELRRDTSCS | ||||||
Compositional bias | 837-860 | Polar residues | ||||
Sequence: DRTANTETDSPLQTNELRRDTSCS | ||||||
Domain | 939-972 | WW | ||||
Sequence: LELPRGWEIKTDPQGKSFFVDHNSRATTFIDPRI | ||||||
Domain | 1209-1544 | HECT | ||||
Sequence: SRKELQRNKLYITFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLPTDLSDLEYLDEEFHQSLQWMKENDITDVLDLTFTVNEEVFGQVTERELKSGGTNVQVTEKNKKEYIERMVKWRVERGVVQQTQALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHIVIRWFWGAVERFNNEQRLRLLQFVTGTSSVPYEGFTALRGSNGLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYTMLYEKLLIAVEETSTFGLE |
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,544
- Mass (Da)174,211
- Last updated2022-08-03 v1
- Checksum3781C24EE8159E42
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8M9QG29 | A0A8M9QG29_DANRE | hecw1b | 1555 | ||
A0A8M3AXK1 | A0A8M3AXK1_DANRE | hecw1b | 1535 | ||
Q1LYI3 | Q1LYI3_DANRE | hecw1b | 1552 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 490-504 | Acidic residues | ||||
Sequence: SDPQPASEEPDADLE | ||||||
Compositional bias | 576-591 | Acidic residues | ||||
Sequence: MGVEEEDEEEEEEGVT | ||||||
Compositional bias | 606-620 | Basic and acidic residues | ||||
Sequence: LPRSRSHERLSDLIQ | ||||||
Compositional bias | 820-836 | Basic and acidic residues | ||||
Sequence: RTMATERREEESGSPRN | ||||||
Compositional bias | 837-860 | Polar residues | ||||
Sequence: DRTANTETDSPLQTNELRRDTSCS |
Keywords
- Technical term