A0A8M9QKA6 · A0A8M9QKA6_DANRE

Function

Catalytic activity

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.
    EC:2.3.2.26 (UniProtKB | ENZYME | Rhea)

Pathway

Protein modification; protein ubiquitination.

Features

Showing features for active site.

115442004006008001,0001,2001,400
TypeIDPosition(s)Description
Active site1512Glycyl thioester intermediate

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Molecular Functionubiquitin protein ligase activity
Biological Processprotein ubiquitination
Biological Processregulation of dendrite morphogenesis
Biological Processubiquitin-dependent protein catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    HECT-type E3 ubiquitin transferase
  • EC number

Gene names

    • Name
      hecw1b
    • Synonyms
      hecw1
      , si:ch211-106n13.1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    A0A8M9QKA6

Proteomes

Organism-specific databases

Subcellular Location

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain190-326C2
Region355-381Disordered
Region425-505Disordered
Compositional bias490-504Acidic residues
Region558-725Disordered
Compositional bias576-591Acidic residues
Compositional bias606-620Basic and acidic residues
Domain759-792WW
Compositional bias820-836Basic and acidic residues
Region820-860Disordered
Compositional bias837-860Polar residues
Domain939-972WW
Domain1209-1544HECT

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,544
  • Mass (Da)
    174,211
  • Last updated
    2022-08-03 v1
  • Checksum
    3781C24EE8159E42
MNEEVMIHRQVILTQNLYQSRFLGLAAMASPSRASQGRRRCKDPIRHSFNPEQFPNVDFQNGVAEDLAAAVLRSTSDTDLLTSHCRSTLTVSTSSYTIGQTQDITLSWDIKEEVDAGDWIGMYLIDEVLSENFLDYKNRGVNGSHKGQIIWKIEASSYFVEPETKICFKYYHGVSGALRATTPCVTVKNPSAPVFKPVATDDVPQSQGRRRLISFSLSDFQATGLKKGMFFNPDPYLKIAIHPGKHSIFPALPHHGQEKRSGIVCNTINPVWQRERFNFVSLPTDVLEIEVKDKFAKSRPIIKRFLGKLSMPVQRLLEKHAIGDRVVSYTLGRRLPTEHVSGQLQFRFEITSSIHPDDEDMSLSTEQPVAAAEAQAQPQAEDTMSLDLGAPELPLDGDTASVEMPMDVESGQSCAAEADVIEEECLEEEQQEGEAAAAAAAMEQSETNAEETTQVLDPINGAEEEEAENNCAFAEESSDARAGEEDEAISDPQPASEEPDADLEEDCSLRIRTTPRRKPRPCSLPVSELETVIASACGEPETPRSHYIRIHHLLHSLPATQPQTGDSAGPEPDRPMGVEEEDEEEEEEGVTLEDHALTPNGPRRTLPRSRSHERLSDLIQMLDGDGHPLGAEGQTGNQRSPDLSPVACCSHMSPRASGPIRAQSLDSARRSESTVFSSQDDEDEMEQPNGILGSETETEQGAQCREPGDGSCQWEEAPDSHVQSPHGIVGNGEVAGPSGRLSQLPALRPDPHHYPTIDEPLPPNWEARIDSHGRVFYVDHINRTTTWQRPTSAATPDGLRRSGSVQQMEQLNRRYQTIQRTMATERREEESGSPRNDRTANTETDSPLQTNELRRDTSCSPGHCQKITLLLQSPAVKFITHPEFFTVLHANYGAYRMFTNSSCLKHMVLKIRRDARNFERYQHNRDLVTFLNRFADAQLELPRGWEIKTDPQGKSFFVDHNSRATTFIDPRIPLQNGRLPNHLTHRQHLQRLRSYSAGEASEVSRTRGVSLLARPGNSLVAAIRNQSQQEPVPLAYNDKIVAFLRQPNIFEVLQERQPSFARNHSLKDKVHHIRTEGTQRLEKLSCDADLVMLLSLFEEDIMSYVPLASFHPGFNFSPRCSPGSSPQNSPGFLERTPLVPACCLSGESSPGTQRARAPAPYRRDFEAKLRNFYRKLEAKGYGQGPGKIKLIVRRDHLLEGTFNQVMAYSRKELQRNKLYITFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFVENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLPTDLSDLEYLDEEFHQSLQWMKENDITDVLDLTFTVNEEVFGQVTERELKSGGTNVQVTEKNKKEYIERMVKWRVERGVVQQTQALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHIVIRWFWGAVERFNNEQRLRLLQFVTGTSSVPYEGFTALRGSNGLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYTMLYEKLLIAVEETSTFGLE

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8M9QG29A0A8M9QG29_DANREhecw1b1555
A0A8M3AXK1A0A8M3AXK1_DANREhecw1b1535
Q1LYI3Q1LYI3_DANREhecw1b1552

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias490-504Acidic residues
Compositional bias576-591Acidic residues
Compositional bias606-620Basic and acidic residues
Compositional bias820-836Basic and acidic residues
Compositional bias837-860Polar residues

Keywords

Sequence databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp