A0A8M9QHJ3 · A0A8M9QHJ3_DANRE
- ProteinSulfatase 2a isoform X3
- Genesulf2a
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids765 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
Cofactor
Note: Binds 1 Ca2+ ion per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 54 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 55 | Ca2+ (UniProtKB | ChEBI) | |||
Active site | 90 | Nucleophile | |||
Binding site | 90 | Ca2+ (UniProtKB | ChEBI); via 3-oxoalanine | |||
Binding site | 319 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 320 | Ca2+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cell surface | |
Cellular Component | endoplasmic reticulum | |
Cellular Component | Golgi stack | |
Cellular Component | plasma membrane | |
Molecular Function | calcium ion binding | |
Molecular Function | glycosaminoglycan binding | |
Molecular Function | N-acetylglucosamine-6-sulfatase activity | |
Biological Process | epithelial structure maintenance | |
Biological Process | glomerular basement membrane development | |
Biological Process | heparan sulfate proteoglycan metabolic process | |
Biological Process | negative regulation of fibroblast growth factor receptor signaling pathway | |
Biological Process | oligodendrocyte development | |
Biological Process | positive regulation of vascular endothelial growth factor production | |
Biological Process | positive regulation of Wnt signaling pathway | |
Biological Process | ventral spinal cord interneuron differentiation |
Keywords
- Molecular function
- Ligand
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionA0A8M9QHJ3
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-24 | ||||
Chain | PRO_5035420446 | 25-765 | |||
Modified residue | 90 | 3-oxoalanine (Cys) | |||
Post-translational modification
The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.
Structure
Family & Domains
Features
Showing features for domain, coiled coil.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 46-377 | Sulfatase N-terminal | |||
Domain | 534-673 | Extracellular sulfatase C-terminal | |||
Coiled coil | 637-664 | ||||
Sequence similarities
Belongs to the sulfatase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length765
- Mass (Da)87,970
- Last updated2022-08-03 v1
- ChecksumC9D513980DF1908E
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8M2BGI3 | A0A8M2BGI3_DANRE | sulf2a | 874 | ||
Q7ZVU8 | Q7ZVU8_DANRE | sulf2a | 873 | ||
A0A8M9QLI6 | A0A8M9QLI6_DANRE | sulf2a | 873 |
Keywords
- Technical term