A0A8M9QHJ3 · A0A8M9QHJ3_DANRE

Function

Cofactor

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Note: Binds 1 Ca2+ ion per subunit.

Features

Showing features for binding site, active site.

1765100200300400500600700
Type
IDPosition(s)Description
Binding site54Ca2+ (UniProtKB | ChEBI)
Binding site55Ca2+ (UniProtKB | ChEBI)
Active site90Nucleophile
Binding site90Ca2+ (UniProtKB | ChEBI); via 3-oxoalanine
Binding site319Ca2+ (UniProtKB | ChEBI)
Binding site320Ca2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcell surface
Cellular Componentendoplasmic reticulum
Cellular ComponentGolgi stack
Cellular Componentplasma membrane
Molecular Functioncalcium ion binding
Molecular Functionglycosaminoglycan binding
Molecular FunctionN-acetylglucosamine-6-sulfatase activity
Biological Processepithelial structure maintenance
Biological Processglomerular basement membrane development
Biological Processheparan sulfate proteoglycan metabolic process
Biological Processnegative regulation of fibroblast growth factor receptor signaling pathway
Biological Processoligodendrocyte development
Biological Processpositive regulation of vascular endothelial growth factor production
Biological Processpositive regulation of Wnt signaling pathway
Biological Processventral spinal cord interneuron differentiation

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • Sulfatase 2a isoform X3

Gene names

    • Name
      sulf2a
    • Synonyms
      Sulf1
      , sulf2
      , zgc:55612

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    A0A8M9QHJ3

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain, modified residue.

Type
IDPosition(s)Description
Signal1-24
ChainPRO_503542044625-765
Modified residue903-oxoalanine (Cys)

Post-translational modification

The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.

Family & Domains

Features

Showing features for domain, coiled coil.

Type
IDPosition(s)Description
Domain46-377Sulfatase N-terminal
Domain534-673Extracellular sulfatase C-terminal
Coiled coil637-664

Sequence similarities

Belongs to the sulfatase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    765
  • Mass (Da)
    87,970
  • Last updated
    2022-08-03 v1
  • Checksum
    C9D513980DF1908E
MAVGWRPATLLLVFILTFICLSDGSTYLSGQRQRSRLQRDRRNVRPNMILILTDDQDIELGSMQAMNKTKRIMMQGGTHFSNAFATTPMCCPSRSTILTGKYVHNHHTYTNNENCSSPSWQAHHEPHTFAVHLNNSGYRTAFFGKYLNEYNGSYVPPGWREWVALVKNSRFYNYTLCRNGIREKHGTQYPKDYLTDVITNDSINYFRMSKRMYPHRPVMMVLSHAAPHGPEDAAPQYSSAFPNASQHITPSYNHAPNPDKHWILRYTGPMKPVHMQFTNMLQRRRLQTLLSVDDSVEKVYNMLVETGELDNTYIIYMSDHGYHIGQFGLVKGKSMPYEFDIRIPFYVRGPNVEAGAINPHIVLNTDLAPTLLDMAGIDIPQDMDGKSILKLLETERPVNSFTRFHSYKKAKLWRDSFLVERGKPLHKLADGKEVEQNSLPKYQRVRDLCQRAEYQTPCEQPGQKWQCIEDGTGMPRLYKCKGMAGLFAPRALGLMAANRGQISAAHPGSDYCDCEPAAPLKRKKALTKKKLKNKKSVPRNRWARSVPYHLDSNVYTLDLEKGYRPLNLNTSLMLGRKQAVYGQNEEYSGMGPTEDNFNSLTPPAALKVTYRCSILMNDTVKCDGGLYKSLQAWKDHKLHIEHEIETLQTKIKNLREVKGHLKEVRPKECECNKNMYQYSSRALFKLKSAQTHSVNRMTSKDKKQWLMKEQKRRKKLRKLLKRLRNNDTCSMPGLTCFTHDNQHWQTAPFWTSTALHATALLSDIT

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8M2BGI3A0A8M2BGI3_DANREsulf2a874
Q7ZVU8Q7ZVU8_DANREsulf2a873
A0A8M9QLI6A0A8M9QLI6_DANREsulf2a873

Keywords

Sequence databases

Similar Proteins

Disclaimer

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