A0A8M9QD71 · A0A8M9QD71_DANRE
- ProteinVoltage-dependent P/Q-type calcium channel subunit alpha-1A
- Genecacna1ab
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids2284 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
Catalytic activity
- Ca2+(in) = Ca2+(out)
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | neuronal cell body | |
Cellular Component | synapse | |
Cellular Component | voltage-gated calcium channel complex | |
Molecular Function | high voltage-gated calcium channel activity | |
Molecular Function | metal ion binding | |
Molecular Function | voltage-gated calcium channel activity | |
Biological Process | calcium ion import across plasma membrane | |
Biological Process | chemical synaptic transmission | |
Biological Process | neuromuscular synaptic transmission | |
Biological Process | swimming behavior | |
Biological Process | thigmotaxis |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameVoltage-dependent P/Q-type calcium channel subunit alpha-1A
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionA0A8M9QD71
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 220-239 | Helical | ||||
Sequence: LLQIGVLLFVAILMFAIIGL | ||||||
Transmembrane | 326-348 | Helical | ||||
Sequence: WMYYVPLIIIGSFFMLNLVLGVL | ||||||
Transmembrane | 466-485 | Helical | ||||
Sequence: AFYWTVISLVALNTLCVAVV | ||||||
Transmembrane | 497-517 | Helical | ||||
Sequence: LYYAEFIFLGLFMSEMLIKMY | ||||||
Transmembrane | 592-614 | Helical | ||||
Sequence: IISLLFLLFLFIVVFALLGMQLF | ||||||
Transmembrane | 667-692 | Helical | ||||
Sequence: IFSVFFIVLTLFGNYTLLNVFLAIAV | ||||||
Transmembrane | 1098-1117 | Helical | ||||
Sequence: LRYFEMCILSVIAMSSIALA | ||||||
Transmembrane | 1137-1158 | Helical | ||||
Sequence: YVFTGVFTFEMLIKMVVLGLIL | ||||||
Transmembrane | 1170-1188 | Helical | ||||
Sequence: FLDFVVVSGALVAFAFTSF | ||||||
Transmembrane | 1236-1258 | Helical | ||||
Sequence: VLNILIVYMLFMFIFAVVAVQLF | ||||||
Transmembrane | 1349-1374 | Helical | ||||
Sequence: IFYVVYFVVFPFFFVNIFVALIIITF | ||||||
Transmembrane | 1430-1449 | Helical | ||||
Sequence: YSIMSLIALNTIILMMKYNG | ||||||
Transmembrane | 1461-1483 | Helical | ||||
Sequence: LNIVFTTFFFMESILKIIAFGVR | ||||||
Transmembrane | 1495-1519 | Helical | ||||
Sequence: FVSVIGSITDILVTELVNNFINLSF | ||||||
Transmembrane | 1540-1569 | Helical | ||||
Sequence: ILLWTFVQSFKALPYVCLLIAILFFIYAII | ||||||
Transmembrane | 1637-1661 | Helical | ||||
Sequence: AYAYFVSFIFLCSFLMLNLFVAVIM |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Glycosylation | 272 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for region, coiled coil, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 11-40 | Disordered | ||||
Sequence: RYGGGGGGGSGQGGPGRGGSRQGGPPGAQR | ||||||
Coiled coil | 688-715 | |||||
Sequence: LAIAVDNLANAQELTKDEQEEEEATTQK | ||||||
Region | 793-856 | Disordered | ||||
Sequence: KTHLDRPLVVNPQENRNNNTNKPRPDDPNPQERSEEHPSRSHHHHSHHHHHHHHHTHHSSRQSL | ||||||
Compositional bias | 803-817 | Polar residues | ||||
Sequence: NPQENRNNNTNKPRP | ||||||
Compositional bias | 832-852 | Basic residues | ||||
Sequence: RSHHHHSHHHHHHHHHTHHSS | ||||||
Region | 872-966 | Disordered | ||||
Sequence: GAGEHRRPRHHQHRRRDEDGGERGRKHRDHHSRGETAGGDAEDGQEKRQRRHRHANHGDGDGRRERSRLHRNKKEGSLSTARPIQPGLPHTESQY | ||||||
Compositional bias | 885-948 | Basic and acidic residues | ||||
Sequence: RRRDEDGGERGRKHRDHHSRGETAGGDAEDGQEKRQRRHRHANHGDGDGRRERSRLHRNKKEGS | ||||||
Region | 1046-1071 | Disordered | ||||
Sequence: ANTEPAKEGEKKEEEEDDGGDEEGHK | ||||||
Domain | 1799-1833 | Voltage-dependent calcium channel alpha-1 subunit IQ | ||||
Sequence: ATDLTVGKIYAAMMIMEYYRQSKAKKLQALREEQN | ||||||
Region | 1835-2284 | Disordered | ||||
Sequence: TPLMFQRMEPSPNQEGGPGLNGLPELPQEPVNSLPPEVGMNESQSWVTSRAQEMCQKSVPENWNPDRPYPDDHHDSRHNPQTITDTSPMRRSTSSLVHGRSGRGVRLDDYSLERVVSEEGHRHAPRRRDRDRDRDRDRSHRTSERSLARYTDADTGLGTDLSTTTQSGDLPPKERERERGRAKDRRHHHHHHHHHGSVDKDRYSHERDYHRHPQDRSDRQWSRSPSEGRGHRQGSSSVSGSPVPSTSGTSTPRRGRRQLPQTPSTPRPHVTYSPAVRKPPYGSPGQGRLRSPSPRNFSPPGHEPPYHRPPSRHASPHPGSPRHASPRSPRHTSPRSPRHGRWGPPDSLEGDGTFYERDYEYERHHEPPAYEQSLSQGNPHPHSHPHPRSPRTARHGPQPHPRRMPNGYRSSSPSPHRRGPHPGPHRPPHGRGPRKGLHEQYSETDEDDWC | ||||||
Compositional bias | 1871-1893 | Polar residues | ||||
Sequence: EVGMNESQSWVTSRAQEMCQKSV | ||||||
Compositional bias | 1900-1914 | Basic and acidic residues | ||||
Sequence: DRPYPDDHHDSRHNP | ||||||
Compositional bias | 1915-1933 | Polar residues | ||||
Sequence: QTITDTSPMRRSTSSLVHG | ||||||
Compositional bias | 1936-1982 | Basic and acidic residues | ||||
Sequence: GRGVRLDDYSLERVVSEEGHRHAPRRRDRDRDRDRDRSHRTSERSLA | ||||||
Compositional bias | 2016-2032 | Basic residues | ||||
Sequence: AKDRRHHHHHHHHHGSV | ||||||
Compositional bias | 2033-2060 | Basic and acidic residues | ||||
Sequence: DKDRYSHERDYHRHPQDRSDRQWSRSPS | ||||||
Compositional bias | 2061-2103 | Polar residues | ||||
Sequence: EGRGHRQGSSSVSGSPVPSTSGTSTPRRGRRQLPQTPSTPRPH | ||||||
Compositional bias | 2131-2150 | Pro residues | ||||
Sequence: FSPPGHEPPYHRPPSRHASP | ||||||
Compositional bias | 2185-2203 | Basic and acidic residues | ||||
Sequence: DGTFYERDYEYERHHEPPA | ||||||
Compositional bias | 2218-2232 | Basic residues | ||||
Sequence: HPHPRSPRTARHGPQ |
Sequence similarities
Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1A subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,284
- Mass (Da)261,017
- Last updated2022-08-03 v1
- Checksum74D4DA44D0744312
Computationally mapped potential isoform sequences
There are 16 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8M9PUZ6 | A0A8M9PUZ6_DANRE | cacna1ab | 2336 | ||
A0A8M9QLP2 | A0A8M9QLP2_DANRE | cacna1ab | 2335 | ||
A0A8M9QLP7 | A0A8M9QLP7_DANRE | cacna1ab | 2330 | ||
A0A8M9QLQ1 | A0A8M9QLQ1_DANRE | cacna1ab | 2119 | ||
A0A8M9PV04 | A0A8M9PV04_DANRE | cacna1ab | 2332 | ||
A0A8M9PV10 | A0A8M9PV10_DANRE | cacna1ab | 2324 | ||
A0A8M9Q7A3 | A0A8M9Q7A3_DANRE | cacna1ab | 2336 | ||
A0A8M9Q7B0 | A0A8M9Q7B0_DANRE | cacna1ab | 2332 | ||
A0A8M9Q7B5 | A0A8M9Q7B5_DANRE | cacna1ab | 2296 | ||
F8W3Z0 | F8W3Z0_DANRE | cacna1ab | 2280 | ||
A0A8M9QD65 | A0A8M9QD65_DANRE | cacna1ab | 2331 | ||
A0A8M9QD59 | A0A8M9QD59_DANRE | cacna1ab | 2335 | ||
A0A8M9QHR9 | A0A8M9QHR9_DANRE | cacna1ab | 1693 | ||
A0A8M9QHQ9 | A0A8M9QHQ9_DANRE | cacna1ab | 2335 | ||
A0A8M9QHR4 | A0A8M9QHR4_DANRE | cacna1ab | 2328 | ||
A0A8M6Z3D5 | A0A8M6Z3D5_DANRE | cacna1ab | 2331 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 803-817 | Polar residues | ||||
Sequence: NPQENRNNNTNKPRP | ||||||
Compositional bias | 832-852 | Basic residues | ||||
Sequence: RSHHHHSHHHHHHHHHTHHSS | ||||||
Compositional bias | 885-948 | Basic and acidic residues | ||||
Sequence: RRRDEDGGERGRKHRDHHSRGETAGGDAEDGQEKRQRRHRHANHGDGDGRRERSRLHRNKKEGS | ||||||
Compositional bias | 1871-1893 | Polar residues | ||||
Sequence: EVGMNESQSWVTSRAQEMCQKSV | ||||||
Compositional bias | 1900-1914 | Basic and acidic residues | ||||
Sequence: DRPYPDDHHDSRHNP | ||||||
Compositional bias | 1915-1933 | Polar residues | ||||
Sequence: QTITDTSPMRRSTSSLVHG | ||||||
Compositional bias | 1936-1982 | Basic and acidic residues | ||||
Sequence: GRGVRLDDYSLERVVSEEGHRHAPRRRDRDRDRDRDRSHRTSERSLA | ||||||
Compositional bias | 2016-2032 | Basic residues | ||||
Sequence: AKDRRHHHHHHHHHGSV | ||||||
Compositional bias | 2033-2060 | Basic and acidic residues | ||||
Sequence: DKDRYSHERDYHRHPQDRSDRQWSRSPS | ||||||
Compositional bias | 2061-2103 | Polar residues | ||||
Sequence: EGRGHRQGSSSVSGSPVPSTSGTSTPRRGRRQLPQTPSTPRPH | ||||||
Compositional bias | 2131-2150 | Pro residues | ||||
Sequence: FSPPGHEPPYHRPPSRHASP | ||||||
Compositional bias | 2185-2203 | Basic and acidic residues | ||||
Sequence: DGTFYERDYEYERHHEPPA | ||||||
Compositional bias | 2218-2232 | Basic residues | ||||
Sequence: HPHPRSPRTARHGPQ |
Keywords
- Technical term