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A0A8M9QD08 · A0A8M9QD08_DANRE

Function

function

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.

Features

Showing features for binding site.

120572004006008001,0001,2001,4001,6001,8002,000
TypeIDPosition(s)Description
Binding site324Ca2+ (UniProtKB | ChEBI)
Binding site664Ca2+ (UniProtKB | ChEBI)
Binding site1019Ca2+ (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentbasal plasma membrane
Cellular Componentmembrane
Cellular Componentribbon synapse
Cellular Componentvoltage-gated calcium channel complex
Molecular Functionhigh voltage-gated calcium channel activity
Molecular Functionmetal ion binding
Molecular Functionvoltage-gated calcium channel activity
Biological Processcalcium ion import across plasma membrane
Biological Processdetection of mechanical stimulus involved in sensory perception
Biological Processdetection of mechanical stimulus involved in sensory perception of sound
Biological Processneuromuscular process controlling balance
Biological Processsynapse organization

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Voltage-dependent L-type calcium channel subunit alpha

Gene names

    • Name
      cacna1da
    • Synonyms
      cacna1d
      , cav1.3a
      , isl
      , si:dz136d19.3
      , si:dz223c6.1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    A0A8M9QD08

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane82-99Helical
Transmembrane119-138Helical
Transmembrane150-169Helical
Transmembrane232-255Helical
Transmembrane310-331Helical
Transmembrane343-365Helical
Transmembrane482-500Helical
Transmembrane520-543Helical
Transmembrane612-632Helical
Transmembrane686-711Helical
Transmembrane805-823Helical
Transmembrane835-858Helical
Transmembrane922-955Helical
Transmembrane1005-1026Helical
Transmembrane1047-1073Helical
Transmembrane1127-1145Helical
Transmembrane1157-1177Helical
Transmembrane1252-1270Helical
Transmembrane1344-1367Helical

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for glycosylation.

TypeIDPosition(s)Description
Glycosylation289N-linked (GlcNAc...) asparagine

Keywords

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region1-21Disordered
Region409-446Disordered
Region721-764Disordered
Compositional bias735-757Acidic residues
Domain1501-1535Voltage-dependent calcium channel alpha-1 subunit IQ
Region1594-1623Disordered
Compositional bias1598-1617Polar residues
Region1639-1820Disordered
Compositional bias1642-1662Basic residues
Compositional bias1663-1684Polar residues
Compositional bias1709-1753Basic and acidic residues
Compositional bias1773-1806Basic and acidic residues
Region1858-1916Disordered
Compositional bias1863-1880Polar residues

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,057
  • Mass (Da)
    234,352
  • Last updated
    2022-08-03 v1
  • MD5 Checksum
    29EFD48AA9C0DB162C5922EFBB9564E3
MSANGPAPPAATPAAPPAAAVPVPSVVPVGSLAQKKRAQYAKSKKQGSSANTRPQRALFCLNLNNPIRRACISLVEWKPFDIFILIAIFANCMALAVYVPFPEDDSNSTNHDLETVEYAFLIIFTIETFLKIIAYGLVMHQNAYVRNGWNMLDFVIVVIGLFSVVLEVLTKEGGEKEEVGENLSAHGHGGKPGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHASCYFQGTDILEDEPAPCAVNGHGRTCPINGTLCKEGWQGPNGGITNFDNFMFAMLTVFQCITMEGWTDVLYWMNDAMGLELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEEEESKRNPSMPASETESMNTENEKGEDEKATCCGPTCQKISKSKFSRRWRRWNRLCRRNCRLAVKSVPFYWLVIILVFLNTLTISSEHYNQPMWLTQVQDVANKVLLAMFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVEFEIMSPLGISVFRCVRLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQVFGGKFNFDETQTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTDDTKKPDEIDEIEDEAKAGEEDEKDNAEEDEEEPDVPAGPRPKISELVKKEKITPIPEGSAFFIFSNTNPVRVACHKLINHHIFTNLILVFIMLSSASLAAEDPIRNFSARNIILGYFDYAFTAIFTVEIVLKMTTYGAFLHKGAFCRNYFNLLDLLVVGVSLVSFGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCNDEAKSSPEECKGTYIMYKEGDVNQPIIQKRHWHNSDFNFDNVLMAMMALFTVSTFEGWPALLYKAIDSNRENMGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSTGFEYIMFVLILLNTICLAVQHYGQSELFNYVMDILNMVFTAVFTVEMVLKLIAFKPRHYFTDAWNTFDALIVVGSVVDIAITEVNNTEDSARISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQVFGKIAMVDHTQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACMPGKLCDPESDYNPGEEMTCGSSFAIIYFITFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTEGNLEQANEELRAVIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRKEEGLVGVHPAQNNTAIALQAGLRTLHDIGPEIRRAISCDLQDDELVDFIPEEDEEIYRRNGGLFGNHINHINGDPRRSSGHQTNATQRPLQVQPPPHYVHMEQPVGRLGRANAMAQQNHHRHHHHHHHHHHHNNSYNKSPKSTNINLNNANVSSLPNGGHNRYYEHAPANGYPGSYYGEYDKPRTPHGQRRRYYETYIRSQGSDRRRPTIRREEEYEEDRYSGEYYSGEEFYEDDSMLSGDRYPNSDQEYETPRGYHHPDSYYEDDEQPLYHDSHRSPKRRLLPPTPQGNRRPSFNFECLRRQSSQDDLPHQRTALPLHLMQHQVMAVAGLDSSRAHRLSPTRSTRSWASPPPTPASKDRTPYYTPLIRVDRPLRDSASSSHSSIRKSSWYTDDPEYQQRNFSPVHLQVPPEYRNQYLQKRGSATSLVEAVLISEGLGRYAKDPKFVAATKHEIADACEMTIDEMESAASHLLNGGITPVVNGVNVFPILGHRDYELQDVSASYSDEEPEPEPRPRYEEDLADEMICITTL

Computationally mapped potential isoform sequences

There are 9 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8M9PUS4A0A8M9PUS4_DANREcacna1da2093
Q6QRQ2Q6QRQ2_DANREcacna1da2082
A0A8M9PUS9A0A8M9PUS9_DANREcacna1da2068
A0A8M9Q738A0A8M9Q738_DANREcacna1da2092
A0A8M9Q745A0A8M9Q745_DANREcacna1da2054
A0A8M9QD03A0A8M9QD03_DANREcacna1da2084
A0A8M9QLJ7A0A8M9QLJ7_DANREcacna1da2082
A0A8M9QHK0A0A8M9QHK0_DANREcacna1da2093
A0A8M9QHK6A0A8M9QHK6_DANREcacna1da2068

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias735-757Acidic residues
Compositional bias1598-1617Polar residues
Compositional bias1642-1662Basic residues
Compositional bias1663-1684Polar residues
Compositional bias1709-1753Basic and acidic residues
Compositional bias1773-1806Basic and acidic residues
Compositional bias1863-1880Polar residues

Keywords

Sequence databases

Similar Proteins

Disclaimer

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