A0A8M9QB21 · A0A8M9QB21_DANRE
- ProteinGlutathione reductase
- Genegsr
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids469 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Maintains high levels of reduced glutathione in the cytosol.
Catalytic activity
- 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+
Cofactor
Note: Binds 1 FAD per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 55 | FAD (UniProtKB | ChEBI) | |||
Binding site | 182-189 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 281 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 322 | FAD (UniProtKB | ChEBI) | |||
Active site | 458 | Proton acceptor | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | mitochondrion | |
Molecular Function | flavin adenine dinucleotide binding | |
Molecular Function | glutathione-disulfide reductase (NADPH) activity | |
Molecular Function | NADP binding | |
Biological Process | cell redox homeostasis | |
Biological Process | cellular response to oxidative stress | |
Biological Process | glutathione metabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGlutathione reductase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionA0A8M9QB21
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Disulfide bond | 46↔51 | Redox-active | |||
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 10-337 | FAD/NAD(P)-binding | |||
Domain | 358-468 | Pyridine nucleotide-disulphide oxidoreductase dimerisation | |||
Sequence similarities
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length469
- Mass (Da)50,741
- Last updated2022-08-03 v1
- ChecksumC53C78E1E2948977
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8M6Z2M1 | A0A8M6Z2M1_DANRE | gsr | 500 | ||
Q503Y5 | Q503Y5_DANRE | gsr | 425 |
Keywords
- Technical term