A0A8M9QB21 · A0A8M9QB21_DANRE

Function

function

Maintains high levels of reduced glutathione in the cytosol.

Catalytic activity

Cofactor

FAD (UniProtKB | Rhea| CHEBI:57692 )

Note: Binds 1 FAD per subunit.

Features

Showing features for binding site, active site.

146950100150200250300350400450
Type
IDPosition(s)Description
Binding site55FAD (UniProtKB | ChEBI)
Binding site182-189NAD+ (UniProtKB | ChEBI)
Binding site281NAD+ (UniProtKB | ChEBI)
Binding site322FAD (UniProtKB | ChEBI)
Active site458Proton acceptor

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentmitochondrion
Molecular Functionflavin adenine dinucleotide binding
Molecular Functionglutathione-disulfide reductase (NADPH) activity
Molecular FunctionNADP binding
Biological Processcell redox homeostasis
Biological Processcellular response to oxidative stress
Biological Processglutathione metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Glutathione reductase
  • EC number

Gene names

    • Name
      gsr
    • Synonyms
      zgc:110010

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    A0A8M9QB21

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for disulfide bond.

TypeIDPosition(s)Description
Disulfide bond46↔51Redox-active

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain10-337FAD/NAD(P)-binding
Domain358-468Pyridine nucleotide-disulphide oxidoreductase dimerisation

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    469
  • Mass (Da)
    50,741
  • Last updated
    2022-08-03 v1
  • Checksum
    C53C78E1E2948977
MASGSVSRFDFLVVGGGSGGLAGARRAAELGATTAVIESHRLGGTCVNVGCVPKKVMWNTSTHAEYLHDHEDYGFEGAKAHFSWQIIKHKRDAYVSRLNQIYRSNLEKGKIEFIHGYARFTDDPEPTVEVNGKKYTATHILISTGGHPSTVSEDDVPGSSLGITSDGFFELESCPKRSVIVGAGYIAVEMAGILSTLGSKTSIIIRQGGVLRNFDALISSNCTKELQNNGIDLRKNTQVKSVKKNGKGLSITLVTKDPDDKDSQEKFDTINDVDCLLWAIGREPNTAGLNLSQIGVKLDERGHIVVDEFQNTSRPGVYAVGDVCGRALLTPVAIAAGRKLAHRLFEGKADSKVDYNNIPTVVFSHPPIGTVGLTEDEAVKTYGKDKVKVYTTSFTPMYYAITTRKSQCIMKLVCAGENEKVVGLHMQGFGCDEMLQGFAVAVNMGATKADFDRTIAIHPTSSEELVTLR

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8M6Z2M1A0A8M6Z2M1_DANREgsr500
Q503Y5Q503Y5_DANREgsr425

Keywords

Sequence databases

Similar Proteins

Disclaimer

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