A0A8M9QAB8 · A0A8M9QAB8_DANRE
- ProteinInositol 1,4,5-trisphosphate receptor
- Geneitpr1a
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids2707 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | inositol 1,4,5 trisphosphate binding | |
Molecular Function | inositol 1,4,5-trisphosphate-gated calcium channel activity | |
Biological Process | release of sequestered calcium ion into cytosol |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameInositol 1,4,5-trisphosphate receptor
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionA0A8M9QAB8
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cytoplasmic vesicle, secretory vesicle membrane ; Multi-pass membrane protein
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 2249-2271 | Helical | ||||
Sequence: FWSNVSFNLAVLINLLVAFFYPL | ||||||
Transmembrane | 2283-2300 | Helical | ||||
Sequence: LSLLLWVCLLGSLGFVLM | ||||||
Transmembrane | 2330-2347 | Helical | ||||
Sequence: LLGAFNVCNKIVFMLSFV | ||||||
Transmembrane | 2367-2394 | Helical | ||||
Sequence: LFHLLYLLICILGLFGHVFFYSLLLFDL | ||||||
Transmembrane | 2415-2437 | Helical | ||||
Sequence: IVLTAVLGLILVYLFSIVGYMFF | ||||||
Transmembrane | 2528-2551 | Helical | ||||
Sequence: LLFFFLVIIIVLNLIFGVIIDTFA |
Keywords
- Cellular component
Interaction
Subunit
Homotetramer.
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 123-177 | MIR | ||||
Sequence: GTVIQYGNVIQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDAAGNEGSWFYIQPF | ||||||
Domain | 242-298 | MIR | ||||
Sequence: EIVLKGGDVVRLFHAEQEKFLTCDEHRKKQYVFLRTTGRQSATSATSSKALWEVEVV | ||||||
Domain | 305-369 | MIR | ||||
Sequence: GGAGYWNSLFRFKHLATGHYLAAEMDSEHEVIRARARNPQDKVMYTLVSVPDGNDISSIFELDPT | ||||||
Domain | 375-431 | MIR | ||||
Sequence: DSLVPRNSYVRLRHLCTNTWVHSTNQPIDKEEEKPVMLRIGTSPLKEDKEAFAIVPV | ||||||
Region | 1145-1164 | Disordered | ||||
Sequence: HHKGVINSSRSNKPKVESTS | ||||||
Compositional bias | 1148-1164 | Polar residues | ||||
Sequence: GVINSSRSNKPKVESTS | ||||||
Region | 1855-1882 | Disordered | ||||
Sequence: DLGNKRRDDNTPDKDTPQRRRGKDSGVV | ||||||
Compositional bias | 1856-1882 | Basic and acidic residues | ||||
Sequence: LGNKRRDDNTPDKDTPQRRRGKDSGVV | ||||||
Compositional bias | 1903-1928 | Basic and acidic residues | ||||
Sequence: GSYRRDADPEETFGTADGDKGGGDKG | ||||||
Region | 1903-1931 | Disordered | ||||
Sequence: GSYRRDADPEETFGTADGDKGGGDKGTEQ | ||||||
Coiled coil | 2652-2686 | |||||
Sequence: LRSLQEKLESTMRLVSNLTNQLTELKEQMTEQRKH |
Domain
The ITPR1 structure has a large solenoid CY assembly built around the central helical bundle made of the C-terminal domains from four IP3R1 subunits. The solenoid scaffold includes domains responsible for binding of ligands and regulatory proteins and is connected via an allosteric nexus at the cytosolic-membrane interface to the transmembrane channel assembly. Six transmembrane helices from each subunit form the central ion-conduction pore.
Sequence similarities
Belongs to the InsP3 receptor family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,707
- Mass (Da)308,886
- Last updated2022-08-03 v1
- Checksum267E37E52AAAC12A
Computationally mapped potential isoform sequences
There are 16 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8M9PGB9 | A0A8M9PGB9_DANRE | itpr1a | 2722 | ||
A0A8M6Z7H7 | A0A8M6Z7H7_DANRE | itpr1a | 2667 | ||
A0A8M6YZS1 | A0A8M6YZS1_DANRE | itpr1a | 2695 | ||
A0A8M9Q732 | A0A8M9Q732_DANRE | itpr1a | 2165 | ||
A0A8M9PTD6 | A0A8M9PTD6_DANRE | itpr1a | 2721 | ||
A0A8M9PTE4 | A0A8M9PTE4_DANRE | itpr1a | 2693 | ||
A0A8M9Q5F0 | A0A8M9Q5F0_DANRE | itpr1a | 2706 | ||
A0A8M9PZD0 | A0A8M9PZD0_DANRE | itpr1a | 2711 | ||
A0A8M9PZD6 | A0A8M9PZD6_DANRE | itpr1a | 2176 | ||
A0A8M3B0M5 | A0A8M3B0M5_DANRE | itpr1a | 2683 | ||
A0A8M3ATJ5 | A0A8M3ATJ5_DANRE | itpr1a | 2710 | ||
F8W4B1 | F8W4B1_DANRE | itpr1a | 2682 | ||
A0A8M3B3K9 | A0A8M3B3K9_DANRE | itpr1a | 2696 | ||
A0A8M9QAC2 | A0A8M9QAC2_DANRE | itpr1a | 2678 | ||
A0A8M2BDG0 | A0A8M2BDG0_DANRE | itpr1a | 2711 | ||
A0A8M9PGC5 | A0A8M9PGC5_DANRE | itpr1a | 2694 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1148-1164 | Polar residues | ||||
Sequence: GVINSSRSNKPKVESTS | ||||||
Compositional bias | 1856-1882 | Basic and acidic residues | ||||
Sequence: LGNKRRDDNTPDKDTPQRRRGKDSGVV | ||||||
Compositional bias | 1903-1928 | Basic and acidic residues | ||||
Sequence: GSYRRDADPEETFGTADGDKGGGDKG |
Keywords
- Technical term