A0A8M9PW40 · A0A8M9PW40_DANRE

Function

function

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

Catalytic activity

Cofactor

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Note: Binds 1 Ca2+ ion per subunit.

Features

Showing features for active site, binding site.

TypeIDPosition(s)Description
Active site385
Binding site386Ca2+ (UniProtKB | ChEBI)
Binding site415Ca2+ (UniProtKB | ChEBI)
Binding site417Ca2+ (UniProtKB | ChEBI)
Active site432
Binding site466Ca2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functioncalcium ion binding
Molecular Functionphosphatidylinositol phospholipase C activity
Biological Processintracellular signal transduction
Biological Processlipid catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
  • EC number

Gene names

    • Name
      plcb4b
    • Synonyms
      plcb4

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    A0A8M9PW40

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-22
ChainPRO_503543903323-12751-phosphatidylinositol 4,5-bisphosphate phosphodiesterase

Family & Domains

Features

Showing features for region, domain, compositional bias, coiled coil.

TypeIDPosition(s)Description
Region533-562Disordered
Domain654-750PI-PLC Y-box
Domain750-878C2
Region933-977Disordered
Compositional bias948-977Polar residues
Coiled coil990-1050
Compositional bias1143-1157Polar residues
Region1143-1169Disordered
Coiled coil1181-1218

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,275
  • Mass (Da)
    144,845
  • Last updated
    2022-08-03 v1
  • Checksum
    C6A445DC012D14C5
MCVDVRRITVIWLLALRLAASAVSRGRSAVLRHAAXXXXXXXXXXXXXXXXXGLRAVMTKSYEFNWQKHIPDFLQEGAAFDRFDEDPFLFEPSCLFKVDEFGFFLTWKSDGKEGQLLECSLINSVRPAVVSKDSKILACLEAAGRSEADLDGRIICVCSGPDLVNLSFMYMVTDNTDTAKKWMEGLKSVIHNFKANNVCPMTCLKKHWMRLSFLTNVNGKIPVRGITRTFGSGKTEKGIFQALKELGLPSGKNDEIEHSAFTFDIFYALTQKICPRTDIEELFKKINGDKSDYLTVEQLVSFLNENQRDPRLNEILFPFYEAKRVTQIIEKYERDAELKKKGRMSSDGFCRYLMSDENAPVFLDRLDLCQEMEHPLSHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLSGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIRETAFVTSEYPVILSFENHCCKPQQYKMAKYCEEIFGDLLLKQPLEGFPLEAGQQLPSPNDLRRKILIKNKRLKPEVEQKQLESFKKHMEAGEISIPAGEDENEEDLDSALDGKEVSSELKAGLLQCVSEDQDAPDSSFRRKITDDDATEISEVTEITDATDVSEASDIESKKKGVESSEDADAEQQLIASYKYEGATTNIHPYLSAMVNYAQPVKFQSFEVAEGQSESQTRSYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNFQTPDLGMQLNQGKFEYNGACGYLLKPDFMRRGDRMFXPFSETPVDGVIAATCSVQVFSGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPYYNEEPFVFRKVILPDLAVLRIAVFDDNSKLIGQRLLPLDGLQAGYRHISLRNEGNKPLSLPTVFCNIVLKTYVPDGFGAIVDALSDPKKFLTIAEKRADQMRALGIETSDIADVPNESSKSDKKSKVSQVKSSVTPQSSAETNNTHNNTNDTRGDHSVVNQVNIEDLKQMKTFIKLLKKQQKELNTLKKRHAKEHNAMQKSHCTQVDKLVAQHDKEKNTLEKLLEKAIKKRGETNCSELKKETAVKIETLTTDHKEKVKDMVAQHTKEWSEMLSGCSSEEQELKDTHITQQSELLKRLMSSVQEQQTSQMKLIHERQSKEMKANQAKSSMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMKQAKEMEQLQKSQREQLEKLEKFNEQLLKSHHSQTAGTLIPHSSLSPLIPLSTHPSLHSXQARDMQKMVKLEEDMERRPATVV

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias948-977Polar residues
Compositional bias1143-1157Polar residues

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

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