A0A8M9PW40 · A0A8M9PW40_DANRE
- Protein1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
- Geneplcb4b
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1275 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
function
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
Catalytic activity
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H+This reaction proceeds in the forward direction.
Cofactor
Note: Binds 1 Ca2+ ion per subunit.
Features
Showing features for active site, binding site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | calcium ion binding | |
Molecular Function | phosphatidylinositol phospholipase C activity | |
Biological Process | intracellular signal transduction | |
Biological Process | lipid catabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionA0A8M9PW40
Proteomes
Organism-specific databases
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-22 | |||||
Sequence: MCVDVRRITVIWLLALRLAASA | ||||||
Chain | PRO_5035439033 | 23-1275 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase | |||
Sequence: VSRGRSAVLRHAAXXXXXXXXXXXXXXXXXGLRAVMTKSYEFNWQKHIPDFLQEGAAFDRFDEDPFLFEPSCLFKVDEFGFFLTWKSDGKEGQLLECSLINSVRPAVVSKDSKILACLEAAGRSEADLDGRIICVCSGPDLVNLSFMYMVTDNTDTAKKWMEGLKSVIHNFKANNVCPMTCLKKHWMRLSFLTNVNGKIPVRGITRTFGSGKTEKGIFQALKELGLPSGKNDEIEHSAFTFDIFYALTQKICPRTDIEELFKKINGDKSDYLTVEQLVSFLNENQRDPRLNEILFPFYEAKRVTQIIEKYERDAELKKKGRMSSDGFCRYLMSDENAPVFLDRLDLCQEMEHPLSHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLSGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIRETAFVTSEYPVILSFENHCCKPQQYKMAKYCEEIFGDLLLKQPLEGFPLEAGQQLPSPNDLRRKILIKNKRLKPEVEQKQLESFKKHMEAGEISIPAGEDENEEDLDSALDGKEVSSELKAGLLQCVSEDQDAPDSSFRRKITDDDATEISEVTEITDATDVSEASDIESKKKGVESSEDADAEQQLIASYKYEGATTNIHPYLSAMVNYAQPVKFQSFEVAEGQSESQTRSYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNFQTPDLGMQLNQGKFEYNGACGYLLKPDFMRRGDRMFXPFSETPVDGVIAATCSVQVFSGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPYYNEEPFVFRKVILPDLAVLRIAVFDDNSKLIGQRLLPLDGLQAGYRHISLRNEGNKPLSLPTVFCNIVLKTYVPDGFGAIVDALSDPKKFLTIAEKRADQMRALGIETSDIADVPNESSKSDKKSKVSQVKSSVTPQSSAETNNTHNNTNDTRGDHSVVNQVNIEDLKQMKTFIKLLKKQQKELNTLKKRHAKEHNAMQKSHCTQVDKLVAQHDKEKNTLEKLLEKAIKKRGETNCSELKKETAVKIETLTTDHKEKVKDMVAQHTKEWSEMLSGCSSEEQELKDTHITQQSELLKRLMSSVQEQQTSQMKLIHERQSKEMKANQAKSSMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMKQAKEMEQLQKSQREQLEKLEKFNEQLLKSHHSQTAGTLIPHSSLSPLIPLSTHPSLHSXQARDMQKMVKLEEDMERRPATVV |
Structure
Family & Domains
Features
Showing features for region, domain, compositional bias, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 533-562 | Disordered | ||||
Sequence: SFKKHMEAGEISIPAGEDENEEDLDSALDG | ||||||
Domain | 654-750 | PI-PLC Y-box | ||||
Sequence: LSAMVNYAQPVKFQSFEVAEGQSESQTRSYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNFQTPDLGMQLNQGKFEYNGACGYLLKPDFMR | ||||||
Domain | 750-878 | C2 | ||||
Sequence: RRGDRMFXPFSETPVDGVIAATCSVQVFSGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPYYNEEPFVFRKVILPDLAVLRIAVFDDNSKLIGQRLLPLDGLQAGYRHISLRNEGNKPL | ||||||
Region | 933-977 | Disordered | ||||
Sequence: DVPNESSKSDKKSKVSQVKSSVTPQSSAETNNTHNNTNDTRGDHS | ||||||
Compositional bias | 948-977 | Polar residues | ||||
Sequence: SQVKSSVTPQSSAETNNTHNNTNDTRGDHS | ||||||
Coiled coil | 990-1050 | |||||
Sequence: MKTFIKLLKKQQKELNTLKKRHAKEHNAMQKSHCTQVDKLVAQHDKEKNTLEKLLEKAIKK | ||||||
Compositional bias | 1143-1157 | Polar residues | ||||
Sequence: ANQAKSSMENSKAIS | ||||||
Region | 1143-1169 | Disordered | ||||
Sequence: ANQAKSSMENSKAISQDKSIKNKAERE | ||||||
Coiled coil | 1181-1218 | |||||
Sequence: KKFLEERKRLAMKQAKEMEQLQKSQREQLEKLEKFNEQ |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,275
- Mass (Da)144,845
- Last updated2022-08-03 v1
- ChecksumC6A445DC012D14C5
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 948-977 | Polar residues | ||||
Sequence: SQVKSSVTPQSSAETNNTHNNTNDTRGDHS | ||||||
Compositional bias | 1143-1157 | Polar residues | ||||
Sequence: ANQAKSSMENSKAIS |
Keywords
- Technical term