A0A8M9PU49 · A0A8M9PU49_DANRE

Function

function

Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm. Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group.
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.

Features

Showing features for binding site.

121862004006008001,0001,2001,4001,6001,8002,000
TypeIDPosition(s)Description
Binding site399Ca2+ (UniProtKB | ChEBI)
Binding site740Ca2+ (UniProtKB | ChEBI)
Binding site1150Ca2+ (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentdendrite
Cellular Componentperikaryon
Cellular Componentpostsynaptic density membrane
Cellular ComponentT-tubule
Cellular Componentvoltage-gated calcium channel complex
Molecular Functionhigh voltage-gated calcium channel activity
Molecular Functionmetal ion binding
Molecular Functionvoltage-gated calcium channel activity
Biological Processcalcium ion import
Biological Processcalcium ion import across plasma membrane
Biological Processcalcium ion transport
Biological Processembryonic cranial skeleton morphogenesis
Biological Processheart looping
Biological Processheart morphogenesis
Biological Processkidney development
Biological Processphysiological cardiac muscle hypertrophy
Biological Processregulation of heart contraction

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Voltage-dependent L-type calcium channel subunit alpha

Gene names

    • Name
      cacna1c
    • Synonyms
      C-LTCC
      , isl

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    A0A8M9PU49

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane, sarcolemma
; Multi-pass membrane protein
Cell projection, dendrite
Membrane
; Multi-pass membrane protein
Perikaryon
Postsynaptic density membrane

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane161-178Helical
Transmembrane198-217Helical
Transmembrane229-245Helical
Transmembrane301-323Helical
Transmembrane385-406Helical
Transmembrane418-440Helical
Transmembrane561-578Helical
Transmembrane598-621Helical
Transmembrane690-709Helical
Transmembrane760-787Helical
Transmembrane931-953Helical
Transmembrane973-994Helical
Transmembrane1052-1081Helical
Transmembrane1179-1204Helical
Transmembrane1255-1273Helical
Transmembrane1285-1308Helical
Transmembrane1386-1404Helical
Transmembrane1476-1500Helical

Keywords

PTM/Processing

Features

Showing features for glycosylation.

TypeIDPosition(s)Description
Glycosylation364N-linked (GlcNAc...) asparagine

Keywords

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region103-131Disordered
Region483-518Disordered
Compositional bias798-843Basic and acidic residues
Region798-894Disordered
Compositional bias844-858Polar residues
Domain1634-1668Voltage-dependent calcium channel alpha-1 subunit IQ
Compositional bias1753-1819Polar residues
Region1753-1822Disordered
Region1980-2001Disordered
Region2152-2186Disordered

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,186
  • Mass (Da)
    245,931
  • Last updated
    2022-08-03 v1
  • Checksum
    B51D075BE999CF52
MLRGLFSWRRLKHERLEEEVEVRFKGKLVSERELGYTHVRPGGSNYSSPSLAPVPSLNEDEHVGGGGGVLGLAPEHIPTPGAPLSWQAAIDAARQAKLMGTTGAPISTASSTQRKRQHYTKPKKQASTASTRPPRALLCLTLKNPIRRACINIVEWKPFEIIILMTIFANCVALAVYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLCHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKGDGGTSMGGKAAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHRTCFFYKDGHKGHIAEEKPAPCAPSSAHGRHCSPPNITQCMMGWEGPNDGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENDDEGLDDDKPRNLSMPASENESVNTDNAPAGDMEGETCCTRMANRISKSKFSRYSRRWNRLCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHHQQPEWLTNVQDIANKVLLALFTGEMLLKMYSLGLQAYFVSLFNRFDSFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKRQNSEKPPLEDEKKEEKIELKSITSDGETPTATKINIDEYTGEDNEEKNPYPVNDFPAGEDDEEEPEMPVGPRPRPLSDIQLKEKAVPMPQAKAFFIFSPSNKFRVLCHKIVNHNIFTNLILFFILLSSISLAAEDPVKNDSFRNQILGYADYVFTGIFTIEIILKMTAYGAFLHKGSFCRNYFNILDLVVVSVSLISSGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTSLLQFMFACIGVQLFKGKFFYCTDTSKQTQAECRGAYILYKDGNVGKPEKAQRSWENSDFNFDDVLQGMMALFAVSTFEGWPGLLYRAIDSHAEDVGPIYNYRVVISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKVWYVVNSTYFEYLMFTLILLNTICLAMQHHGQSQSFNKAMNILNMLFTGLFTVEMILKLIAFKPRHYFVDAWNTFDALIVVGSVVDIAITEVNGLQNTEDNARISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALRDNSQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACSPNRPCEKGSEINHSSEDCGSHFAIFYFVSFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGNLEQANEELRAIVKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLVAKIPPKTALSLQAGLRTLHDMGPEIRRAISGDLTVEEELERAMKETVCAASEDDIFRVKRSGGLFGNHVNYYHQSDGHVSFPQSFTTQRPLHISKSGSPGEAESPSHQKLVDSTFTPSSYSSSGSNANINNANNTAIGHRYPKPTVSTVDGQTGPPLTTIPLPRPTWCFPNKRSCFYDTFMRSDSSDSRLPIIRREEASTDETYDETFLDERDQAMLSMDMLEFQDEESKQLAPMVEAEVGEERRPWQSPRRRAFLCPTALGRRSSFHLECLRKHNRPDVSQKTALPLHLVHHQALAVAGLSPLLRRSHSPTLFTRLCSTPPASPSGRSGGGPCYQPVPSLRLEGSGSYEKLNSSMPSVNCSSWYSDSNGNHSGRAQRPVSLTVPPVTRRDSISLAHGSAGSLVEAVLISEGLGRYAHDPSFIQVAKQEIAEACDMTMEEMENAADNILNANAPPNANGNLLPFIQCRDTGSQESRCSLSLGLSPATGSDGALEAELEESEGAGQRNSPLMEDEDMECVTSL

Computationally mapped potential isoform sequences

There are 20 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8M9Q050A0A8M9Q050_DANREcacna1c2202
A0A8M9Q055A0A8M9Q055_DANREcacna1c2193
A0A8M9Q061A0A8M9Q061_DANREcacna1c2185
A0A8M9Q067A0A8M9Q067_DANREcacna1c2183
A0A8M9PU44A0A8M9PU44_DANREcacna1c2200
A0A8M9Q5R0A0A8M9Q5R0_DANREcacna1c2191
A0A8M9Q5R3A0A8M9Q5R3_DANREcacna1c2184
A0A8M9Q5R5A0A8M9Q5R5_DANREcacna1c2163
A0A8M9PU55A0A8M9PU55_DANREcacna1c2183
A0A8M9Q5Q9A0A8M9Q5Q9_DANREcacna1c2201
A0A8M9QAX1A0A8M9QAX1_DANREcacna1c2202
A0A8M9QAX6A0A8M9QAX6_DANREcacna1c2193
A0A8M9QAY0A0A8M9QAY0_DANREcacna1c2185
A0A8M9QAY5A0A8M9QAY5_DANREcacna1c2183
A0A8M3B905A0A8M3B905_DANREcacna1c2179
A0A8M9PH00A0A8M9PH00_DANREcacna1c2184
A0A8M9PH04A0A8M9PH04_DANREcacna1c1701
A0A8M9PGZ0A0A8M9PGZ0_DANREcacna1c2201
A0A8M9PGZ5A0A8M9PGZ5_DANREcacna1c2186
Q90ZA7Q90ZA7_DANREcacna1c2168

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias798-843Basic and acidic residues
Compositional bias844-858Polar residues
Compositional bias1753-1819Polar residues

Keywords

Sequence databases

Similar Proteins

Disclaimer

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