A0A8M9PTH8 · A0A8M9PTH8_DANRE
- ProteinSolute carrier family 12 member 2 isoform X1
- Geneslc12a2
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1134 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
Catalytic activity
- 2 chloride(out) + K+(out) + Na+(out) = 2 chloride(in) + K+(in) + Na+(in)This reaction proceeds in the forward direction.
2 chloride (out)CHEBI:17996+ K+ (out)CHEBI:29103+ Na+ (out)CHEBI:29101= 2 chloride (in)CHEBI:17996+ K+ (in)CHEBI:29103+ Na+ (in)CHEBI:29101
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Molecular Function | chloride:monoatomic cation symporter activity | |
Biological Process | sodium ion transport |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionA0A8M9PTH8
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 209-228 | Helical | ||||
Sequence: WIKGVLVRCMLNIWGVMLFI | ||||||
Transmembrane | 240-269 | Helical | ||||
Sequence: AYSCIIVIMATVVTTITGCSTSAIATNGFV | ||||||
Transmembrane | 289-310 | Helical | ||||
Sequence: SIGLIFAFANAVAVAMYVVGFA | ||||||
Transmembrane | 331-350 | Helical | ||||
Sequence: IRVIGTITVILLLGISVAGM | ||||||
Transmembrane | 356-379 | Helical | ||||
Sequence: AQIFLLVILITAIFNYFIGSFIAV | ||||||
Transmembrane | 408-430 | Helical | ||||
Sequence: FFSVFSIFFPAATGILAGANISG | ||||||
Transmembrane | 442-466 | Helical | ||||
Sequence: GTLLAILITGLVYVGVAISAGACIV | ||||||
Transmembrane | 580-600 | Helical | ||||
Sequence: YFLTFGIALAFILIAELNVIA | ||||||
Transmembrane | 606-624 | Helical | ||||
Sequence: FFLASYALINFSVFHASLA | ||||||
Transmembrane | 636-659 | Helical | ||||
Sequence: YNMWASLAGAILCCVVMFIINWWA |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-73 | Disordered | ||||
Sequence: MSASPPISAGDYLSAPEPDALKPAGPTPSQSRFQVDLVTESAGDGETTVGFDSSPPEYVAEPPPDGLRDSVSG | ||||||
Region | 91-121 | Disordered | ||||
Sequence: PDAAPAETAQNGDTVMSEGSLHSSTGGQQHH | ||||||
Compositional bias | 94-121 | Polar residues | ||||
Sequence: APAETAQNGDTVMSEGSLHSSTGGQQHH | ||||||
Domain | 124-175 | Amino acid permease N-terminal | ||||
Sequence: DTHTNTYYLRTFGHNTIDAVPKIDFYRQTAAPLGEKLIRPTLSELHDELDKE | ||||||
Domain | 212-717 | Amino acid permease/ SLC12A | ||||
Sequence: GVLVRCMLNIWGVMLFIRMTWIVGQAGIAYSCIIVIMATVVTTITGCSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVVELLMDSGLLMIDQTNDIRVIGTITVILLLGISVAGMEWEAKAQIFLLVILITAIFNYFIGSFIAVDSKKKFGFFSYDAGILAENFGPDFRGQTFFSVFSIFFPAATGILAGANISGDLADPQMAIPKGTLLAILITGLVYVGVAISAGACIVRDATGIESNFTLISNCTDAACKYGYDFSSCRPTVEGEVSSCKFGLHNDFQVMSVVSGFSPLISAGIFSATLSSALASLVSAPKVFQALCKDNIYPGIAIFGKGYGKNNEPLRGYFLTFGIALAFILIAELNVIAPIISNFFLASYALINFSVFHASLANSPGWRPSFKYYNMWASLAGAILCCVVMFIINWWAALLTNVIVLSLYIYVSYKKPDVNWGSSTQALTYHQALTHSLQLCGVADHIKTFRPQCL | ||||||
Domain | 726-1134 | SLC12A transporter C-terminal | ||||
Sequence: RPAILHLVHAFTKNVGLMLCGHVRISSRRPNFKELNSDMLRYQRWLLNNNSKAFYTCVVAEDLRQGTQYMLQAAGLGRLRPNTLVIGFKNDWRTGDIKEVETYINLIHDAFDFQYGVVILRLREGLDISHIQDDSSGMKDVVVSVDISKDSDGDSSKPSSKATSVQNSPAVQKDEDDDGKAHTQPLLKKDKKSPTVPLNVADQRLLDASQQFQQKQGKGTVDVWWLFDDGGLTLLIPYLIANKKKWKDCKIRVFIGGKINRIDHDRRAMATLLSKFRIDFSDITVLGDINTKPKSEGLTEFAEMIEPYKLREDDMEQEAAEKLKSEEPWRITDNELELYKAKGNRQIRLNELLKEHSSTANLIVMSMPLARKGAVSSALYMAWLDTLSKDLPPILLVRGNHQSVLTFYS | ||||||
Region | 874-919 | Disordered | ||||
Sequence: KDSDGDSSKPSSKATSVQNSPAVQKDEDDDGKAHTQPLLKKDKKSP | ||||||
Compositional bias | 896-914 | Basic and acidic residues | ||||
Sequence: VQKDEDDDGKAHTQPLLKK |
Sequence similarities
Belongs to the SLC12A transporter family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,134
- Mass (Da)123,927
- Last updated2022-08-03 v1
- Checksum1D3BEC55BEDB36E2
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A0G2KTI4 | S12A2_DANRE | slc12a2 | 1136 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 94-121 | Polar residues | ||||
Sequence: APAETAQNGDTVMSEGSLHSSTGGQQHH | ||||||
Compositional bias | 896-914 | Basic and acidic residues | ||||
Sequence: VQKDEDDDGKAHTQPLLKK |
Keywords
- Technical term