A0A8M9PS80 · A0A8M9PS80_DANRE
- Proteinprotein-tyrosine-phosphatase
- Geneptprsa
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1920 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
Catalytic activity
- O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | protein tyrosine phosphatase activity | |
Biological Process | olfactory bulb development | |
Biological Process | protein dephosphorylation | |
Biological Process | synaptic membrane adhesion |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameprotein-tyrosine-phosphatase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionA0A8M9PS80
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 1275-1298 | Helical | ||||
Sequence: LIWVVGPVLAVVFIICIVIAILLY |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-27 | |||||
Sequence: MMPTGHLPILLSLSALLLSPLLTGSLA | ||||||
Chain | PRO_5035429428 | 28-1920 | protein-tyrosine-phosphatase | |||
Sequence: LSSPRFTKVPVDMIGVSGGVVSFVCQATGDPKPKVTWNKKGKRVNSQRIETIEFDEGAGAVLRIQPLRAPRDENVYECQAENSEGEINVQAKLSIIREDLLPPGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPIDPNTSNGRIKQLRSEGTPIRGALQIENTEETDQGKYECVASNVEGVRYSSPANLYVRELREVRRVPPRFSILPTSQEIMPGGSVNITCVAVGSPMPYVKWMLNSEDLTPEDEMPVGRNVLELNSVRESANYTCVAMSSLGIIETVAQITVKSLPKPPGTPVVTETTATSITITWDSGNPEPVSHYIIQYRAKSPESKFETVDSITTTRYSIGGLSPNTDYEIRVSAFNTIGQGPPSEPVEARTGEQAPASPPRNIQARIISQNTVLVRWDEPDEPNGQIKGYRVYYTMDPTLPMSMWQIHNVQDSVLTTIQSLVTSETYTIRVLAFTSVGDGPFSDPIHVKVLQGVPGQPTNFQVGEVSDTGVELTWEPAFEKEGIISYELHYKEGKDGPLGKKKFAPTSSFVVDGLRPNTEYFFSLAAVSSKGIGAFTNDLAQTTSQAKPSAPPQDIKCSSSSSTVLMVSWRPPPAESQNGELAGYIVRYAVVGAGAEVSTEHVEAPTSDQILLQRLEKWTMYRVTVAASTSVGSGPESEPLLCRTDEDVPGAPPRRVEVEVLNSTAIKVMWRSLLPGKQHGQIRGYQVHYVRVENGESRGLPLIKDVMLADAQWEMDDTAEYEMVIGGLQPDTTYSITVAAYTTKGDGARSKPKLVLTKGAVPGPPFLSVNQNSESTAIIRWQPPDYVAPGLEVQGYRLQFGRKDVNPLATLEFGPQELEYSISNIHRGATYIFKVSAKSKSGFGEEATQELRVPEEVPRGYPQITEGSNITCCSVQFSWLPPVLAERNGAITEYTLSYQEAGTISGPKELRLPADENSYILNSLRPNAVYDVKIRAHTSVGPGPYSPPIQYRTVAYEADVPRNFTVKLVTKTTVLLSWKFYDSRFPYKCTIEYHRQKSDIDARMTKTLITNLRPNTTYEFRISCQDSSDGGPKHKLVARTAPHIQIRKPELDLKRESESTLTIVFPPLETKDLIKAIYVVVVPLKKGKGPMRHIKSPDELDLEELLGERRLGLHHSGTTRQLKQVDGKRPYIAASFKPSSMPPSFTLGNQMMYGSFENRALDRGQEYVLFILAELNTTGVKAFVSSPYTDPIMAPDLDPQPLESGGDGLIWVVGPVLAVVFIICIVIAILLYKNKRKESEPRTKCLLNNADITPHHPTDPVEMRRINFQTPGMMNHPPIPISELAEHTELLKANDNLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILAPIEGITGSDYINSNYIDGYRKQNAYIATQGPLPETFGDFWRMVWEQRAATVVMMTRLEEKSRIKCDQYWPSRGTETYGMIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIIAHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRSQRNYMVQTEDQYSFIHDALLEAVACGNTEVAARSLFSYIQKLAQVEAGEHVSGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYETTRVCLQPIRGLEGSDYINSSFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHYAT |
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 31-121 | Ig-like | ||||
Sequence: PRFTKVPVDMIGVSGGVVSFVCQATGDPKPKVTWNKKGKRVNSQRIETIEFDEGAGAVLRIQPLRAPRDENVYECQAENSEGEINVQAKLS | ||||||
Domain | 133-228 | Ig-like | ||||
Sequence: PNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPIDPNTSNGRIKQLRSEGTPIRGALQIENTEETDQGKYECVASNVEGVRYSSPANLY | ||||||
Domain | 240-322 | Ig-like | ||||
Sequence: PRFSILPTSQEIMPGGSVNITCVAVGSPMPYVKWMLNSEDLTPEDEMPVGRNVLELNSVRESANYTCVAMSSLGIIETVAQIT | ||||||
Domain | 329-419 | Fibronectin type-III | ||||
Sequence: PPGTPVVTETTATSITITWDSGNPEPVSHYIIQYRAKSPESKFETVDSITTTRYSIGGLSPNTDYEIRVSAFNTIGQGPPSEPVEARTGEQ | ||||||
Region | 404-425 | Disordered | ||||
Sequence: GQGPPSEPVEARTGEQAPASPP | ||||||
Domain | 424-518 | Fibronectin type-III | ||||
Sequence: PPRNIQARIISQNTVLVRWDEPDEPNGQIKGYRVYYTMDPTLPMSMWQIHNVQDSVLTTIQSLVTSETYTIRVLAFTSVGDGPFSDPIHVKVLQG | ||||||
Domain | 522-612 | Fibronectin type-III | ||||
Sequence: QPTNFQVGEVSDTGVELTWEPAFEKEGIISYELHYKEGKDGPLGKKKFAPTSSFVVDGLRPNTEYFFSLAAVSSKGIGAFTNDLAQTTSQA | ||||||
Domain | 617-713 | Fibronectin type-III | ||||
Sequence: PPQDIKCSSSSSTVLMVSWRPPPAESQNGELAGYIVRYAVVGAGAEVSTEHVEAPTSDQILLQRLEKWTMYRVTVAASTSVGSGPESEPLLCRTDED | ||||||
Domain | 718-826 | Fibronectin type-III | ||||
Sequence: PPRRVEVEVLNSTAIKVMWRSLLPGKQHGQIRGYQVHYVRVENGESRGLPLIKDVMLADAQWEMDDTAEYEMVIGGLQPDTTYSITVAAYTTKGDGARSKPKLVLTKGA | ||||||
Domain | 827-926 | Fibronectin type-III | ||||
Sequence: VPGPPFLSVNQNSESTAIIRWQPPDYVAPGLEVQGYRLQFGRKDVNPLATLEFGPQELEYSISNIHRGATYIFKVSAKSKSGFGEEATQELRVPEEVPRG | ||||||
Domain | 927-1022 | Fibronectin type-III | ||||
Sequence: YPQITEGSNITCCSVQFSWLPPVLAERNGAITEYTLSYQEAGTISGPKELRLPADENSYILNSLRPNAVYDVKIRAHTSVGPGPYSPPIQYRTVAY | ||||||
Domain | 1026-1110 | Fibronectin type-III | ||||
Sequence: VPRNFTVKLVTKTTVLLSWKFYDSRFPYKCTIEYHRQKSDIDARMTKTLITNLRPNTTYEFRISCQDSSDGGPKHKLVARTAPHI | ||||||
Domain | 1365-1620 | Tyrosine-protein phosphatase | ||||
Sequence: LSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILAPIEGITGSDYINSNYIDGYRKQNAYIATQGPLPETFGDFWRMVWEQRAATVVMMTRLEEKSRIKCDQYWPSRGTETYGMIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIIAHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRSQRNYMVQTEDQYSFIHDALLEA | ||||||
Domain | 1540-1611 | Tyrosine specific protein phosphatases | ||||
Sequence: LAFLRRVKTCNPPDAGPIIAHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRSQRNYMVQTEDQYS | ||||||
Domain | 1652-1911 | Tyrosine-protein phosphatase | ||||
Sequence: MELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYETTRVCLQPIRGLEGSDYINSSFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEY | ||||||
Domain | 1829-1902 | Tyrosine specific protein phosphatases | ||||
Sequence: IDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQ |
Sequence similarities
Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,920
- Mass (Da)214,420
- Last updated2022-08-03 v1
- Checksum0E97534588B2F788
Computationally mapped potential isoform sequences
There are 34 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8M9PJX4 | A0A8M9PJX4_DANRE | ptprsa | 1945 | ||
A0A8M9PK00 | A0A8M9PK00_DANRE | ptprsa | 1502 | ||
A0A8M9PK04 | A0A8M9PK04_DANRE | ptprsa | 1512 | ||
A0A8M9PJY3 | A0A8M9PJY3_DANRE | ptprsa | 1936 | ||
A0A8M9PJY7 | A0A8M9PJY7_DANRE | ptprsa | 1928 | ||
A0A8M9PJX8 | A0A8M9PJX8_DANRE | ptprsa | 1942 | ||
A0A8M9PJZ1 | A0A8M9PJZ1_DANRE | ptprsa | 1831 | ||
A0A8M9PJZ6 | A0A8M9PJZ6_DANRE | ptprsa | 1520 | ||
A0A8M9PS70 | A0A8M9PS70_DANRE | ptprsa | 1924 | ||
A0A8M9PS75 | A0A8M9PS75_DANRE | ptprsa | 1530 | ||
A0A8M9PS86 | A0A8M9PS86_DANRE | ptprsa | 1518 | ||
A0A8M9PS56 | A0A8M9PS56_DANRE | ptprsa | 1944 | ||
A0A8M9PS58 | A0A8M9PS58_DANRE | ptprsa | 1941 | ||
A0A8M9PS65 | A0A8M9PS65_DANRE | ptprsa | 1932 | ||
A0A8M9P4J6 | A0A8M9P4J6_DANRE | ptprsa | 1923 | ||
A0A8M9P4K2 | A0A8M9P4K2_DANRE | ptprsa | 1901 | ||
A0A8M9P4K6 | A0A8M9P4K6_DANRE | ptprsa | 1498 | ||
A0A8M9P4J8 | A0A8M9P4J8_DANRE | ptprsa | 1529 | ||
A0A8M9PVP4 | A0A8M9PVP4_DANRE | ptprsa | 1942 | ||
A0A8M9PVP8 | A0A8M9PVP8_DANRE | ptprsa | 1936 | ||
A0A8M9PVQ3 | A0A8M9PVQ3_DANRE | ptprsa | 1927 | ||
A0A8M9PVQ7 | A0A8M9PVQ7_DANRE | ptprsa | 1533 | ||
A0A8M9P4I5 | A0A8M9P4I5_DANRE | ptprsa | 1944 | ||
A0A8M9P4J0 | A0A8M9P4J0_DANRE | ptprsa | 1940 | ||
A0A8M9P4J3 | A0A8M9P4J3_DANRE | ptprsa | 1929 | ||
A0A8M9PVR1 | A0A8M9PVR1_DANRE | ptprsa | 1905 | ||
A0A8M9PVR5 | A0A8M9PVR5_DANRE | ptprsa | 1506 | ||
A0A8M9PE85 | A0A8M9PE85_DANRE | ptprsa | 1943 | ||
A0A8M9PE90 | A0A8M9PE90_DANRE | ptprsa | 1939 | ||
A0A8M9PE92 | A0A8M9PE92_DANRE | ptprsa | 1928 | ||
A0A8M9PE98 | A0A8M9PE98_DANRE | ptprsa | 1923 | ||
A0A8M9PEA2 | A0A8M9PEA2_DANRE | ptprsa | 1524 | ||
A0A8M9PEA7 | A0A8M9PEA7_DANRE | ptprsa | 1916 | ||
A0A8M9PEB3 | A0A8M9PEB3_DANRE | ptprsa | 1513 |
Keywords
- Technical term