A0A8M9PRV2 · A0A8M9PRV2_DANRE
- ProteinRho-associated protein kinase
- Generock1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1375 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]This reaction proceeds in the forward direction.
Cofactor
Activity regulation
Activated by RHOA binding. Inhibited by Y-27632.
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | bleb | |
Cellular Component | centriole | |
Cellular Component | cytoplasm | |
Cellular Component | cytoplasmic stress granule | |
Cellular Component | cytoskeleton | |
Cellular Component | Golgi membrane | |
Cellular Component | lamellipodium | |
Cellular Component | plasma membrane | |
Cellular Component | ruffle | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | Rho-dependent protein serine/threonine kinase activity | |
Molecular Function | small GTPase binding | |
Biological Process | actomyosin structure organization | |
Biological Process | cortical actin cytoskeleton organization | |
Biological Process | embryonic morphogenesis | |
Biological Process | mitotic cytokinesis | |
Biological Process | regulation of cell junction assembly | |
Biological Process | regulation of cytoskeleton organization | |
Biological Process | Rho protein signal transduction |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameRho-associated protein kinase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionA0A8M9PRV2
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain, coiled coil, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 78-340 | Protein kinase | ||||
Sequence: YEVVKVIGRGAFGEVQLVRHKATRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSNWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDGIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKDGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNALTFPEDSDISKDAKSLICAFLTDREVRLGRNGVDEIKRHGFF | ||||||
Domain | 343-411 | AGC-kinase C-terminal | ||||
Sequence: DQWTWENIRETAAPVVPELSCDTDTSNFDDIEEDRGEEETFPIPKAFVGNQLPFVGFTYYSNNLFSQES | ||||||
Coiled coil | 422-708 | |||||
Sequence: TKEDKSLLENLQKRIYQLEEQVHSEMQLRDEMEQKCRASNTKLDKIMKELDEESNLRKSVEANMSILEKDKIMIQHRATEYQRKADQEAEKRRNLENEVSTLKEQLEDLRKISQNNDKIAQLQNQLGEANDLLRAESDTVMRLRKSHTEMGKTMSQLESINRELQEKIRAAESVKQQLEKELLQLQTTLDTERRSCSQGSEEIRELQVRIMGLQEDNKNLKQSLTKVETERKHVQERCNILEKEKNSLEIDLNYKLKTLQQRLDQELTEHRITKAQLTDKYESIEES | ||||||
Coiled coil | 748-986 | |||||
Sequence: LKQSVQKMEQLMKQKERLEDEVKDLRVQLEQETGKRVMSQNELKNWKMDSERLKGTEKQLKQEINAALENKRSVEFQLAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQVKELKDEIEEKNRQTQEALKRVQDLNSEKESLSAQLDLTMTKAESEQLARALQEEQYVELSQEYKKAVSRYKQEISEKDSTISQLEDSNKTLTKDVEILSKEKTEFNERIQAQEQEFAAEREELTNS | ||||||
Domain | 952-1018 | RhoBD | ||||
Sequence: TKDVEILSKEKTEFNERIQAQEQEFAAEREELTNSIKANYEKALNIERTLKTQAVNKLAEIMNRKDM | ||||||
Region | 1014-1036 | Disordered | ||||
Sequence: NRKDMKDQKKRGSTTDLRKKEKE | ||||||
Coiled coil | 1076-1110 | |||||
Sequence: RNELQMQLDSKESDIEQLREKLNDLQLRVDNSSVT | ||||||
Domain | 1123-1322 | PH | ||||
Sequence: ESRLEGWLAIPNRANIKRYGWKKQYVVVSSKKILFYNDEQDKEQSNPSMVLDIDKLFHVRPVTQGDVYRAETDEIPRIFQILYANEGECRKETDVESVPQGDKANCLPHKGHEFIPTLYHFPTNCEACSKPLWHVFKPPPALECRRCHVKCHKDHLDKKEDMITPCKVNYDVTSARDMLLLALSQDEQKKWIGHLGKKIP | ||||||
Domain | 1233-1288 | Phorbol-ester/DAG-type | ||||
Sequence: GHEFIPTLYHFPTNCEACSKPLWHVFKPPPALECRRCHVKCHKDHLDKKEDMITPC | ||||||
Region | 1318-1375 | Disordered | ||||
Sequence: GKKIPKTPPSTFARQSPRSMSVRSGANQSFRKNPKNVPGKPSRAQSILQAADTTSSTC | ||||||
Compositional bias | 1326-1375 | Polar residues | ||||
Sequence: PSTFARQSPRSMSVRSGANQSFRKNPKNVPGKPSRAQSILQAADTTSSTC |
Sequence similarities
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,375
- Mass (Da)160,140
- Last updated2022-08-03 v1
- ChecksumA22640A9AC6A712B
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A0R4IVY5 | A0A0R4IVY5_DANRE | rock1 | 1359 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1326-1375 | Polar residues | ||||
Sequence: PSTFARQSPRSMSVRSGANQSFRKNPKNVPGKPSRAQSILQAADTTSSTC |
Keywords
- Technical term