A0A8M9PJM4 · A0A8M9PJM4_DANRE
- ProteinA disintegrin and metalloproteinase with thrombospondin motifs 3 isoform X1
- Geneadamts3
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1192 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
Cofactor
Note: Binds 1 zinc ion per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 251 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 251 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 343 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 390 | Zn2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: H | ||||||
Active site | 391 | |||||
Sequence: E | ||||||
Binding site | 394 | Zn2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: H | ||||||
Binding site | 400 | Zn2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: H | ||||||
Binding site | 447 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 450 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 450 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular matrix | |
Cellular Component | extracellular region | |
Molecular Function | metal ion binding | |
Molecular Function | metalloendopeptidase activity | |
Biological Process | extracellular matrix organization | |
Biological Process | lymphangiogenesis | |
Biological Process | protein processing |
Keywords
- Molecular function
- Ligand
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionA0A8M9PJM4
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-20 | |||||
Sequence: MVVLSLRLLIVGVVVSLTSA | ||||||
Chain | PRO_5035442364 | 21-1192 | ||||
Sequence: HLAGEIIDKEDLLKNRLKEYGLITPISTDAEGHFLSHFLSANHKQRVKRDVLEGSAPAPDRLFFNITVFGKEFHLRLHPNQRLVAPGAMVEWHDDIEIAGNATDNRTHFERILKRELLKTDCTFIGDITDVPGASVAINNCDGLAGMIRTDSDEYFIEPLEQGTQEHEERGRVHVVYRRSAVLQTPSDISLDYQPIEPELDTPRMLDNIAKQVNKTVRRRRHAGDEDYNIEILLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLEVHINVVLVRMIMLGYAKSISLIERGNPSRSLENVCRWAFVQQKEDPEHSEHHDHAIFLTRQGFGPTGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDETAMGSVMAPLVQAAFHRYHWSMCSGQELKRYIHSYDCLLDDPFKHDWPQLPELPGINYSMDEQCRFDFGVGYKICTSFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTECAPGKWCYKGHCMWKNANQVKQDGAWGAWSKYGSCSRSCGMGVRFRTRQCNNPVPSNGGQDCPGVNYEYQLCNTDDCPKHFEDFRAQQCQLRNSHFEYQNAKHHWLPYEHPDANKRCHLYCQSKETGDVAYMKQLVHDGTRCSYKDPYSICVRGECVKVGCDREIGSNKVEDKCGVCGGDNSHCRTVKGTFTRVPKKAGKTRGAFLLPKGARNVYLNETADSRNVMGYLKMFLIPPGARHVIIQEHEASPQILAIKNQATGHYVLNGKGEDARSRRFIEMGVEWDYLVEEDVETLHTDGPLNDAIVVLIIPKDNETRSTLMYKYIIHEDSVPLNNNNVIQEDTYEWALKSWSQCSRPCAGGFQYTKYGCRKKGDNKMVHRGYCDVNKKPKPIRRMCNLQDCTQPQWITEEWEHCTKTCGSLGYQIRTVRCVQFLHEGTNRSIHSKYCNGEKPEMRRACNRVACPAQWRTGAWSECSVSCGEGVSRRLVTCRIGDQCTGEKPESQKPCRPRPCHDEPCGGDKSIFCQMEVLARYCSIPGYNKLCCESCSRRSGTFAPLLHEAAETEEELRFGSASQLLETLSAAANGSLKVPQQHQRGSTSQGQFSKQAATPPPRKHNTENSKTQKRLKPSTRNLPALSIHSSWSEDGVKDAPMQLESFQESQWPTTSSEVER | ||||||
Disulfide bond | 325↔374 | |||||
Sequence: CRWAFVQQKEDPEHSEHHDHAIFLTRQGFGPTGMQGYAPVTGMCHPVRSC | ||||||
Disulfide bond | 368↔447 | |||||
Sequence: CHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDETAMGSVMAPLVQAAFHRYHWSMCSGQELKRYIHSYDC | ||||||
Disulfide bond | 407↔433 | |||||
Sequence: CGDETAMGSVMAPLVQAAFHRYHWSMC | ||||||
Disulfide bond | 474↔499 | |||||
Sequence: CRFDFGVGYKICTSFRTFDPCKQLWC | ||||||
Disulfide bond | 485↔508 | |||||
Sequence: CTSFRTFDPCKQLWCSHPDNPYFC | ||||||
Disulfide bond | 494↔527 | |||||
Sequence: CKQLWCSHPDNPYFCKTKKGPPLDGTECAPGKWC | ||||||
Disulfide bond | 521↔532 | |||||
Sequence: CAPGKWCYKGHC | ||||||
Disulfide bond | 555↔592 | |||||
Sequence: CSRSCGMGVRFRTRQCNNPVPSNGGQDCPGVNYEYQLC | ||||||
Disulfide bond | 559↔597 | |||||
Sequence: CGMGVRFRTRQCNNPVPSNGGQDCPGVNYEYQLCNTDDC | ||||||
Disulfide bond | 570↔582 | |||||
Sequence: CNNPVPSNGGQDC |
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain, compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 248-452 | Peptidase M12B | ||||
Sequence: YNIEILLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLEVHINVVLVRMIMLGYAKSISLIERGNPSRSLENVCRWAFVQQKEDPEHSEHHDHAIFLTRQGFGPTGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDETAMGSVMAPLVQAAFHRYHWSMCSGQELKRYIHSYDCLLDDP | ||||||
Domain | 1028-1071 | PLAC | ||||
Sequence: RPRPCHDEPCGGDKSIFCQMEVLARYCSIPGYNKLCCESCSRRS | ||||||
Compositional bias | 1107-1137 | Polar residues | ||||
Sequence: SLKVPQQHQRGSTSQGQFSKQAATPPPRKHN | ||||||
Region | 1107-1192 | Disordered | ||||
Sequence: SLKVPQQHQRGSTSQGQFSKQAATPPPRKHNTENSKTQKRLKPSTRNLPALSIHSSWSEDGVKDAPMQLESFQESQWPTTSSEVER | ||||||
Compositional bias | 1175-1192 | Polar residues | ||||
Sequence: LESFQESQWPTTSSEVER |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,192
- Mass (Da)134,921
- Last updated2022-08-03 v1
- Checksum1385783A6E35B50B
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
S5RVW8 | S5RVW8_DANRE | adamts3 | 1164 | ||
A0A8M6Z0H1 | A0A8M6Z0H1_DANRE | adamts3 | 802 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1107-1137 | Polar residues | ||||
Sequence: SLKVPQQHQRGSTSQGQFSKQAATPPPRKHN | ||||||
Compositional bias | 1175-1192 | Polar residues | ||||
Sequence: LESFQESQWPTTSSEVER |
Keywords
- Technical term