A0A8M9PH62 · A0A8M9PH62_DANRE

Function

Catalytic activity

  • AMP + inosine = adenosine + IMP
  • CMP + inosine = cytidine + IMP
  • GMP + H2O = guanosine + phosphate
    This reaction proceeds in the forward direction.
  • GMP + inosine = guanosine + IMP
  • H2O + IMP = inosine + phosphate
    This reaction proceeds in the forward direction.
    EC:3.1.3.99 (UniProtKB | ENZYME | Rhea)
  • H2O + XMP = phosphate + xanthosine
    This reaction proceeds in the forward direction.
  • a 2'-deoxyribonucleoside + a ribonucleoside 5'-phosphate = a 2'-deoxyribonucleoside 5'-phosphate + a ribonucleoside
    EC:2.7.1.77 (UniProtKB | ENZYME | Rhea)
  • a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate
    This reaction proceeds in the forward direction.
    EC:3.1.3.5 (UniProtKB | ENZYME | Rhea)
  • dGMP + H2O = 2'-deoxyguanosine + phosphate
    This reaction proceeds in the forward direction.
  • dGMP + inosine = 2'-deoxyguanosine + IMP
  • dIMP + H2O = 2'-deoxyinosine + phosphate
    This reaction proceeds in the forward direction.
  • dIMP + inosine = 2'-deoxyinosine + IMP
  • inosine + UMP = IMP + uridine

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for active site, binding site.

TypeIDPosition(s)Description
Active site55Nucleophile
Binding site55Mg2+ (UniProtKB | ChEBI)
Active site57Proton donor
Binding site57GMP (UniProtKB | ChEBI)
Binding site354Mg2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Function5'-nucleotidase activity
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functiontransferase activity
Biological ProcessGMP metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytosolic purine 5'-nucleotidase
  • EC number
  • Alternative names
    • Cytosolic nucleoside phosphotransferase 5'N

Gene names

    • Name
      nt5c2b
    • Synonyms
      im:7162273
      , zgc:153651

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    A0A8M9PH62

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region538-564Disordered
Compositional bias550-564Acidic residues

Sequence similarities

Belongs to the 5'(3')-deoxyribonucleotidase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    564
  • Mass (Da)
    65,249
  • Last updated
    2022-08-03 v1
  • Checksum
    FDAB07B6C3645D6A
MGLTDQLEQRQTLRMQRAGSAWRSESWDIVQCYATTRVFVNRSLAMEKIKCFGFDMDYTLAVYKSPEYESLGFDLTVERLVSIGYPQELLGFVYDPTFPTRGLVFDNMYGNLLKVDAYGNILVCVHGFNFLRGPDIRELYPNKFIQRDDTERFYILNTLFNLPETYLLACLVDFFSNCDRYSSCETGFKDGDLFMSFKSMFQDVRDAVDWVHFKGTLKEKTVENLEKYVVKDAKLPLLLSRMNEVSKVFLATNSDYKYTHKIMTYLFDFPHGPKHGTPHRPWQSYFDLILVDARKPLFFGEGTVLRQVDTTTGRLKIGTYTGPLQHGIVYSGGSSDIVCDLLGAKGKDILYIGDHIFGDILKSKKRQGWRTFLVIPELAQELHVWTDKSSLFEELQGLDIFLAELYKHLDSSSNERPDISAIQRRMKKVTHDMDMCYGMMGSLFRSGSRQTLFASQVMRYADLYAASFINLLYYPFSYLFRAAHVLMPHESTVEHAHVETDTESPLATRNRHCVDCKDIDCKRNQLTRSISEIKPPHLFAQPPQEITHCHDEDDDEEEEEEEEE

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8M9PUC7A0A8M9PUC7_DANREnt5c2b370
F1QAK5F1QAK5_DANREnt5c2b562

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias550-564Acidic residues

Keywords

Sequence databases

Similar Proteins

Disclaimer

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