A0A8M9PGZ0 · A0A8M9PGZ0_DANRE
- ProteinVoltage-dependent L-type calcium channel subunit alpha
- Genecacna1c
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids2201 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
function
Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm. Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group.
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | dendrite | |
Cellular Component | perikaryon | |
Cellular Component | postsynaptic density membrane | |
Cellular Component | T-tubule | |
Cellular Component | voltage-gated calcium channel complex | |
Molecular Function | high voltage-gated calcium channel activity | |
Molecular Function | metal ion binding | |
Molecular Function | voltage-gated calcium channel activity | |
Biological Process | calcium ion import | |
Biological Process | calcium ion import across plasma membrane | |
Biological Process | calcium ion transport | |
Biological Process | embryonic cranial skeleton morphogenesis | |
Biological Process | heart looping | |
Biological Process | heart morphogenesis | |
Biological Process | kidney development | |
Biological Process | physiological cardiac muscle hypertrophy | |
Biological Process | regulation of heart contraction |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameVoltage-dependent L-type calcium channel subunit alpha
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionA0A8M9PGZ0
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane, sarcolemma ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 161-178 | Helical | ||||
Sequence: IIILMTIFANCVALAVYI | ||||||
Transmembrane | 198-217 | Helical | ||||
Sequence: LFLIIFTVEAFLKVIAYGLL | ||||||
Transmembrane | 229-245 | Helical | ||||
Sequence: NLLDFIIVVVGLFSAIL | ||||||
Transmembrane | 301-323 | Helical | ||||
Sequence: LLHIALLVLFVIIIYAIIGLELF | ||||||
Transmembrane | 385-406 | Helical | ||||
Sequence: FAFAMLTVFQCITMEGWTDVLY | ||||||
Transmembrane | 418-440 | Helical | ||||
Sequence: WLYFVTLIIIGSFFVLNLVLGVL | ||||||
Transmembrane | 561-578 | Helical | ||||
Sequence: VFYWLVIFLVFLNTLTIA | ||||||
Transmembrane | 598-621 | Helical | ||||
Sequence: VLLALFTGEMLLKMYSLGLQAYFV | ||||||
Transmembrane | 690-709 | Helical | ||||
Sequence: LLLLLFLFIIIFSLLGMQLF | ||||||
Transmembrane | 760-787 | Helical | ||||
Sequence: GMLVCIYFIILFICGNYILLNVFLAIAV | ||||||
Transmembrane | 930-952 | Helical | ||||
Sequence: IVNHNIFTNLILFFILLSSISLA | ||||||
Transmembrane | 972-993 | Helical | ||||
Sequence: YVFTGIFTIEIILKMTAYGAFL | ||||||
Transmembrane | 1051-1080 | Helical | ||||
Sequence: HVVQCVFVAIRTIGNIVIVTSLLQFMFACI | ||||||
Transmembrane | 1178-1203 | Helical | ||||
Sequence: IFFIIYIIIIAFFMMNIFVGFVIVTF | ||||||
Transmembrane | 1254-1272 | Helical | ||||
Sequence: YFEYLMFTLILLNTICLAM | ||||||
Transmembrane | 1284-1305 | Helical | ||||
Sequence: AMNILNMLFTGLFTVEMILKLI | ||||||
Transmembrane | 1401-1424 | Helical | ||||
Sequence: ALPYVALLIVMLFFIYAVIGMQMF | ||||||
Transmembrane | 1491-1515 | Helical | ||||
Sequence: AIFYFVSFYMLCAFLIINLFVAVIM |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Glycosylation | 364 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 103-131 | Disordered | ||||
Sequence: GAPISTASSTQRKRQHYTKPKKQASTAST | ||||||
Region | 483-518 | Disordered | ||||
Sequence: IDPENDDEGLDDDKPRNLSMPASENESVNTDNAPAG | ||||||
Compositional bias | 798-843 | Basic and acidic residues | ||||
Sequence: SAQKEEEEEKERKKLARTASPEKRQNSEKPPLEDEKKEEKIELKSI | ||||||
Region | 798-894 | Disordered | ||||
Sequence: SAQKEEEEEKERKKLARTASPEKRQNSEKPPLEDEKKEEKIELKSITSDGETPTATKINIDEYTGEDNEEKNPYPVNDFPGEDDEEEPEMPVGPRPR | ||||||
Compositional bias | 844-858 | Polar residues | ||||
Sequence: TSDGETPTATKINID | ||||||
Compositional bias | 859-875 | Basic and acidic residues | ||||
Sequence: EYTGEDNEEKNPYPVND | ||||||
Domain | 1649-1683 | Voltage-dependent calcium channel alpha-1 subunit IQ | ||||
Sequence: DDEVTVGKFYATFLIQEYFRKFKKRKEQGLVAKIP | ||||||
Compositional bias | 1768-1834 | Polar residues | ||||
Sequence: RPLHISKSGSPGEAESPSHQKLVDSTFTPSSYSSSGSNANINNANNTAIGHRYPKPTVSTVDGQTGP | ||||||
Region | 1768-1837 | Disordered | ||||
Sequence: RPLHISKSGSPGEAESPSHQKLVDSTFTPSSYSSSGSNANINNANNTAIGHRYPKPTVSTVDGQTGPPLT | ||||||
Region | 1995-2016 | Disordered | ||||
Sequence: RLCSTPPASPSGRSGGGPCYQP | ||||||
Region | 2167-2201 | Disordered | ||||
Sequence: GSDGALEAELEESEGAGQRNSPLMEDEDMECVTSL |
Sequence similarities
Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1C subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,201
- Mass (Da)247,442
- Last updated2022-08-03 v1
- ChecksumDEB0B5B48AC950E5
Computationally mapped potential isoform sequences
There are 20 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8M9Q050 | A0A8M9Q050_DANRE | cacna1c | 2202 | ||
A0A8M9Q055 | A0A8M9Q055_DANRE | cacna1c | 2193 | ||
A0A8M9Q061 | A0A8M9Q061_DANRE | cacna1c | 2185 | ||
A0A8M9Q067 | A0A8M9Q067_DANRE | cacna1c | 2183 | ||
A0A8M9PU44 | A0A8M9PU44_DANRE | cacna1c | 2200 | ||
A0A8M9PU49 | A0A8M9PU49_DANRE | cacna1c | 2186 | ||
A0A8M9Q5R0 | A0A8M9Q5R0_DANRE | cacna1c | 2191 | ||
A0A8M9Q5R3 | A0A8M9Q5R3_DANRE | cacna1c | 2184 | ||
A0A8M9Q5R5 | A0A8M9Q5R5_DANRE | cacna1c | 2163 | ||
A0A8M9PU55 | A0A8M9PU55_DANRE | cacna1c | 2183 | ||
A0A8M9Q5Q9 | A0A8M9Q5Q9_DANRE | cacna1c | 2201 | ||
A0A8M9QAX1 | A0A8M9QAX1_DANRE | cacna1c | 2202 | ||
A0A8M9QAX6 | A0A8M9QAX6_DANRE | cacna1c | 2193 | ||
A0A8M9QAY0 | A0A8M9QAY0_DANRE | cacna1c | 2185 | ||
A0A8M9QAY5 | A0A8M9QAY5_DANRE | cacna1c | 2183 | ||
A0A8M3B905 | A0A8M3B905_DANRE | cacna1c | 2179 | ||
A0A8M9PH00 | A0A8M9PH00_DANRE | cacna1c | 2184 | ||
A0A8M9PH04 | A0A8M9PH04_DANRE | cacna1c | 1701 | ||
A0A8M9PGZ5 | A0A8M9PGZ5_DANRE | cacna1c | 2186 | ||
Q90ZA7 | Q90ZA7_DANRE | cacna1c | 2168 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 798-843 | Basic and acidic residues | ||||
Sequence: SAQKEEEEEKERKKLARTASPEKRQNSEKPPLEDEKKEEKIELKSI | ||||||
Compositional bias | 844-858 | Polar residues | ||||
Sequence: TSDGETPTATKINID | ||||||
Compositional bias | 859-875 | Basic and acidic residues | ||||
Sequence: EYTGEDNEEKNPYPVND | ||||||
Compositional bias | 1768-1834 | Polar residues | ||||
Sequence: RPLHISKSGSPGEAESPSHQKLVDSTFTPSSYSSSGSNANINNANNTAIGHRYPKPTVSTVDGQTGP |
Keywords
- Technical term