A0A8M9PCW2 · A0A8M9PCW2_DANRE
- Proteinnon-specific protein-tyrosine kinase
- Geneptk2ab
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1140 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
Catalytic activity
- ATP + L-tyrosyl-[protein] = ADP + H+ + O-phospho-L-tyrosyl-[protein]
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | cell projection | |
Cellular Component | cytoskeleton | |
Cellular Component | focal adhesion | |
Cellular Component | plasma membrane | |
Molecular Function | ATP binding | |
Molecular Function | protein tyrosine kinase activity | |
Biological Process | lens fiber cell morphogenesis | |
Biological Process | midbrain-hindbrain boundary morphogenesis | |
Biological Process | positive regulation of cell population proliferation | |
Biological Process | regulation of cellular component organization | |
Biological Process | regulation of protein localization | |
Biological Process | signal complex assembly |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namenon-specific protein-tyrosine kinase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionA0A8M9PCW2
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Peripheral membrane protein
Membrane ; Peripheral membrane protein
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 71-388 | FERM | ||||
Sequence: RVLKIFHYFESSSEPCSWASNIRHGDSTDVRGIIQKILDIHKVRCVSCFGLRLSHLRTGEIHWLHPDMGVSHVRERYEHSHPQDDWRYELRIRYLPKGFLNQFTEDQPTLNYFYHQVKSDYMMEIADQVDQDIALKLGCLEIRRFFRDMPGNALDKKSNYELLEKDVGLRRFFPKSLLDSVKAKSLRKLIQQTFKQFANLNNEQCMLKFFEILSPIYRFDKECFKCALGSSWVISVELAIGPEEGISYLTDKGSNPTHLANFTQVQTIQFEERERKGMLLLDVAGAPEPLTVTTTTLNTAENMADLIDGYCRLVSGTS | ||||||
Domain | 476-734 | Protein kinase | ||||
Sequence: IELGRCIGEGQFGDVHQGIYICPDTPALSVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQIRKYNLDLASLILFSYQLSTALAYLESKRFVHRDIAARNVLVSSVDCVKLGDFGLSRYMEDSSYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMYGVKPFQGVKNNDVIGRIENGERLAMPPNCPPTLYSLMTKCWAYDPSKRPRFTELKGQLSTIL | ||||||
Region | 738-780 | Disordered | ||||
Sequence: KAQQEERSRMEMRRQVPVSWDSGGSDEAPPKGPRTRPSVPPGI | ||||||
Region | 799-828 | Disordered | ||||
Sequence: YRFTQPSRPGYPSPRSSEGFYPSPQHMGQH | ||||||
Compositional bias | 917-931 | Basic and acidic residues | ||||
Sequence: RLLKPDGRSSRGSTE | ||||||
Region | 917-985 | Disordered | ||||
Sequence: RLLKPDGRSSRGSTERDDGSLQGPTGNQHIYQPIGKAEHAAPPKKPPRPGAPSHAAGVSGLNPTESYNE |
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,140
- Mass (Da)129,078
- Last updated2022-08-03 v1
- ChecksumAA7728C3A1D50380
Computationally mapped potential isoform sequences
There are 17 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8M9P7Q1 | A0A8M9P7Q1_DANRE | ptk2ab | 1142 | ||
A0A8M9PM54 | A0A8M9PM54_DANRE | ptk2ab | 1139 | ||
A0A8M9PM62 | A0A8M9PM62_DANRE | ptk2ab | 1132 | ||
A0A8M9PJ68 | A0A8M9PJ68_DANRE | ptk2ab | 1139 | ||
A0A8M9PJ73 | A0A8M9PJ73_DANRE | ptk2ab | 1126 | ||
A0A2R8RR02 | A0A2R8RR02_DANRE | ptk2ab | 1101 | ||
A0A8M2B4H7 | A0A8M2B4H7_DANRE | ptk2ab | 1104 | ||
A0A8M2B4I9 | A0A8M2B4I9_DANRE | ptk2ab | 1088 | ||
A0A8M9P7Q4 | A0A8M9P7Q4_DANRE | ptk2ab | 1136 | ||
A0A8M9P7Q9 | A0A8M9P7Q9_DANRE | ptk2ab | 1104 | ||
A0A8M2B500 | A0A8M2B500_DANRE | ptk2ab | 1091 | ||
A0A8M2B527 | A0A8M2B527_DANRE | ptk2ab | 1097 | ||
A0A8M9NZ24 | A0A8M9NZ24_DANRE | ptk2ab | 1107 | ||
A0A8M9NZ18 | A0A8M9NZ18_DANRE | ptk2ab | 1136 | ||
A0A8M9PCW5 | A0A8M9PCW5_DANRE | ptk2ab | 1133 | ||
A0A8M9PCX0 | A0A8M9PCX0_DANRE | ptk2ab | 1104 | ||
Q98SN4 | Q98SN4_DANRE | ptk2ab | 1050 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 917-931 | Basic and acidic residues | ||||
Sequence: RLLKPDGRSSRGSTE |
Keywords
- Technical term