A0A8M9P9T2 · A0A8M9P9T2_DANRE

Function

function

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

Catalytic activity

Cofactor

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Note: Binds 1 Ca2+ ion per subunit.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site315Ca2+ (UniProtKB | ChEBI)
Binding site350Ca2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functioncalcium ion binding
Molecular Functionphosphatidylinositol phospholipase C activity
Biological Processatrioventricular canal development
Biological Processdetermination of heart left/right asymmetry
Biological Processintracellular signal transduction
Biological Processlipid catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
  • EC number

Gene names

    • Name
      plcb2

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    A0A8M9P9T2

Proteomes

Organism-specific databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region405-484Disordered
Compositional bias419-447Polar residues
Compositional bias456-481Basic and acidic residues
Domain494-610PI-PLC Y-box
Domain610-737C2
Region795-918Disordered
Compositional bias827-889Basic and acidic residues
Region966-992Disordered
Compositional bias1006-1056Basic and acidic residues
Region1006-1083Disordered
Compositional bias1057-1082Polar residues
Region1128-1152Disordered

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,152
  • Mass (Da)
    130,094
  • Last updated
    2022-08-03 v1
  • Checksum
    1DBBE12AB5C052EE
MKSPPNWPAGPEFSLRMSRNRHSLQEPDIKDYLVKGDRFTKWKEDSKKTTPVTMKMDPKGFYLYWVNQSKETEFLDVATIRDTRAGKYAKMPKHPKVRNIFNMDFPDSHHLAKTLTIVTGPDTVNLTYHNFFAAKEVAQMWADDILAIAYNTLRANSCRQLYLDKVYVRLTLQTNKDGKIPVKNIFKMFPADKKRVDAALAAANLPRGKFDTIKTDVFTEAAFKTFIMNLCPRPEINDIFTSFTKGKGFMTKEMFAKFLNEKQRDSRLNEELFPPMRPEQVKSLIEKYEPSSSNASRSECARKHHSDTIYRLTIDQYESFSEVFLLQDVIEAIAESAFKTSKYPVVLSFENHVDSVKQQEKMANYCRTIFGDALLIDLLDKYPLKPGQPIPSPSELMGKILIKNKKSSAAPSKAEPSKKPAAQEQTSDPAEGSEATQSTDATQPTPNNPEGTDPPAATGEDREEHDDHDEQDEEKMKNSDEGTAGQEVTAYEEMSALVNYVQPNKFISFENAAKKNRCFVISSFVETKGESLIAKNAVDWVEYNKRQLSRIYPKGTRVDSSNYSPQPFWSAGCQFVALNYQTMDFPMQLNMALFEFNGRTGYLLKHDVMRRSDKKFDPFCDRIDTIIASTLTIKIYSGQFLSDKAVKTGVEVELIGLPKDPKRKYRTKMSSTANGINPDWNEEPFIFEKVLLPEMAYLRLVVQEEGGKFIGHRIIPLDALQTGFQHIGLRSESNMPLMLPSLFVHIEMKDYVPAAFADFSDALFNPVKTSKPPKTESLTYVCEYELPLADGVQKAATAAPAAEPKEAESAETPAEGGAAPPAEQNTTETKPEEKPEPEAKPEPEPEAKPEPESEAKPEPEPEPKPEEKTEPEPDPKPEEKVKAEPTPEETPEAVVDAAVTETKESSEETPADPSDPITVSCEELQQHKNFLKVTKKQEKDLKDMEKKFQKRREDLIQKYSDQFKALKKKNSTKKNGAEGSDPADQMNELKQKLKSELRAVLVEQHDQLKKKKEQHNTERLTKLLETATEKHCSEMKALNSEPKKKDKMKKCKSTEQLDNDSTQASESSSAEGSPQEQTLKKKQAATLAKIRELISQLNKEAVSEHAKKMWSLPGDLSEAVNSCVKPHFPEHVEKNGENRSENSGQYSQVFVG

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias419-447Polar residues
Compositional bias456-481Basic and acidic residues
Compositional bias827-889Basic and acidic residues
Compositional bias1006-1056Basic and acidic residues
Compositional bias1057-1082Polar residues

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

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