A0A8M9P9T2 · A0A8M9P9T2_DANRE
- Protein1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
- Geneplcb2
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1152 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
function
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
Catalytic activity
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H+This reaction proceeds in the forward direction.
Cofactor
Note: Binds 1 Ca2+ ion per subunit.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | calcium ion binding | |
Molecular Function | phosphatidylinositol phospholipase C activity | |
Biological Process | atrioventricular canal development | |
Biological Process | determination of heart left/right asymmetry | |
Biological Process | intracellular signal transduction | |
Biological Process | lipid catabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionA0A8M9P9T2
Proteomes
Organism-specific databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 405-484 | Disordered | ||||
Sequence: KKSSAAPSKAEPSKKPAAQEQTSDPAEGSEATQSTDATQPTPNNPEGTDPPAATGEDREEHDDHDEQDEEKMKNSDEGTA | ||||||
Compositional bias | 419-447 | Polar residues | ||||
Sequence: KPAAQEQTSDPAEGSEATQSTDATQPTPN | ||||||
Compositional bias | 456-481 | Basic and acidic residues | ||||
Sequence: AATGEDREEHDDHDEQDEEKMKNSDE | ||||||
Domain | 494-610 | PI-PLC Y-box | ||||
Sequence: MSALVNYVQPNKFISFENAAKKNRCFVISSFVETKGESLIAKNAVDWVEYNKRQLSRIYPKGTRVDSSNYSPQPFWSAGCQFVALNYQTMDFPMQLNMALFEFNGRTGYLLKHDVMR | ||||||
Domain | 610-737 | C2 | ||||
Sequence: RRSDKKFDPFCDRIDTIIASTLTIKIYSGQFLSDKAVKTGVEVELIGLPKDPKRKYRTKMSSTANGINPDWNEEPFIFEKVLLPEMAYLRLVVQEEGGKFIGHRIIPLDALQTGFQHIGLRSESNMPL | ||||||
Region | 795-918 | Disordered | ||||
Sequence: AATAAPAAEPKEAESAETPAEGGAAPPAEQNTTETKPEEKPEPEAKPEPEPEAKPEPESEAKPEPEPEPKPEEKTEPEPDPKPEEKVKAEPTPEETPEAVVDAAVTETKESSEETPADPSDPIT | ||||||
Compositional bias | 827-889 | Basic and acidic residues | ||||
Sequence: TETKPEEKPEPEAKPEPEPEAKPEPESEAKPEPEPEPKPEEKTEPEPDPKPEEKVKAEPTPEE | ||||||
Region | 966-992 | Disordered | ||||
Sequence: LKKKNSTKKNGAEGSDPADQMNELKQK | ||||||
Compositional bias | 1006-1056 | Basic and acidic residues | ||||
Sequence: DQLKKKKEQHNTERLTKLLETATEKHCSEMKALNSEPKKKDKMKKCKSTEQ | ||||||
Region | 1006-1083 | Disordered | ||||
Sequence: DQLKKKKEQHNTERLTKLLETATEKHCSEMKALNSEPKKKDKMKKCKSTEQLDNDSTQASESSSAEGSPQEQTLKKKQ | ||||||
Compositional bias | 1057-1082 | Polar residues | ||||
Sequence: LDNDSTQASESSSAEGSPQEQTLKKK | ||||||
Region | 1128-1152 | Disordered | ||||
Sequence: FPEHVEKNGENRSENSGQYSQVFVG |
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,152
- Mass (Da)130,094
- Last updated2022-08-03 v1
- Checksum1DBBE12AB5C052EE
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 419-447 | Polar residues | ||||
Sequence: KPAAQEQTSDPAEGSEATQSTDATQPTPN | ||||||
Compositional bias | 456-481 | Basic and acidic residues | ||||
Sequence: AATGEDREEHDDHDEQDEEKMKNSDE | ||||||
Compositional bias | 827-889 | Basic and acidic residues | ||||
Sequence: TETKPEEKPEPEAKPEPEPEAKPEPESEAKPEPEPEPKPEEKTEPEPDPKPEEKVKAEPTPEE | ||||||
Compositional bias | 1006-1056 | Basic and acidic residues | ||||
Sequence: DQLKKKKEQHNTERLTKLLETATEKHCSEMKALNSEPKKKDKMKKCKSTEQ | ||||||
Compositional bias | 1057-1082 | Polar residues | ||||
Sequence: LDNDSTQASESSSAEGSPQEQTLKKK |
Keywords
- Technical term