A0A8M6Z789 · A0A8M6Z789_DANRE
- ProteinExtracellular calcium-sensing receptor
- Genecasr
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids956 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | G protein-coupled receptor activity | |
Molecular Function | metal ion binding | |
Biological Process | calcium ion homeostasis | |
Biological Process | skeletal system development |
Keywords
- Molecular function
- Ligand
Names & Taxonomy
Protein names
- Recommended nameExtracellular calcium-sensing receptor
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionA0A8M6Z789
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 611-636 | Helical | ||||
Sequence: FGIALALFAVLGVLLTAFVLGVFVQF | ||||||
Transmembrane | 648-669 | Helical | ||||
Sequence: ELSFLLLFSLICCFSSSLIFIG | ||||||
Transmembrane | 681-703 | Helical | ||||
Sequence: PAFGISFVLCISCILVKTNRVLL | ||||||
Transmembrane | 724-743 | Helical | ||||
Sequence: FLLVFLFTFVQVMICVVWLY | ||||||
Transmembrane | 770-790 | Helical | ||||
Sequence: ALGFLIGYTCLLAAICFFFAF | ||||||
Transmembrane | 802-824 | Helical | ||||
Sequence: AKFITFSMLIFFIVWISFIPAYF | ||||||
Transmembrane | 830-852 | Helical | ||||
Sequence: FVSAVEVIAILASSFSLLACIFF |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-23 | |||||
Sequence: MRFHLKFYLHYLVLLGSSCVIST | ||||||
Chain | PRO_5035424158 | 24-956 | Extracellular calcium-sensing receptor | |||
Sequence: YGPNQRAQKTGDILLGGLFPMHFGVASKDQDLAARPESTECVRYNFRGFRWLQSMIFAIEEINNSSTLLPNITLGYRIFDTCNTVSKALEASLSFVAQNKIDSLNLDEFCNCTGNIPSTIAVVGASGSAVSTAVADLLGLFYIPQISYASSSRLLSNKNQYKSFMRTIPTDEYQAIAMAAIIEHFQWNWVIAIASDDEYGRPGIEKFENEMFHRDICIDLNVLISQYVDEAEIRRLADRIQNSSAKVIVVFASGPDIEPLVKEMVRRNITDRVWLASEAWASSSLVAKPEYLDVMGGTIGFALRAGHIPGFKDFLQQVHPKKSSHNEFVREFWEETFNCYLEDSPRNADSENGSTSFRPLCTGEEDIASVETPYLDYTHLRISYNVYVAVYAIAQALQDILTCTPGKGLFSNGSCADIRKVEAWQVLKQLRHLNFIDSMGERVRFDNGSELSANYTIINWHRSPEDGSVVFKEVGYYSIHNKNVAKLSIDKSKILWNGRLTEVMCCFSFLYQVPFSNCSVECEPGTRKGIIDGEPTCCFECTECSDGEYSDHKDASFCVKCPNNSWSNGNHTSCFLKQIEFLSWTEPFGIALALFAVLGVLLTAFVLGVFVQFRDTPIVKASNRELSFLLLFSLICCFSSSLIFIGEPQDWTCRVRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSLHRKWWGLNLQFLLVFLFTFVQVMICVVWLYNAPPGSYKNYDIDEIIFITCNEGSMMALGFLIGYTCLLAAICFFFAFKSRKLPENFTEAKFITFSMLIFFIVWISFIPAYFSTYGKFVSAVEVIAILASSFSLLACIFFNKVYIILLKPSRNTIEEVRCSTAAHAFKAAAKATLRHSSGFRKRSSSVGGSSASSPSSSISMKTNGNEMESPSTRRHGSKPRVSFGSGTVSLSLSFEEARNSMK |
Keywords
- PTM
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 611-874 | G-protein coupled receptors family 3 profile | ||||
Sequence: FGIALALFAVLGVLLTAFVLGVFVQFRDTPIVKASNRELSFLLLFSLICCFSSSLIFIGEPQDWTCRVRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSLHRKWWGLNLQFLLVFLFTFVQVMICVVWLYNAPPGSYKNYDIDEIIFITCNEGSMMALGFLIGYTCLLAAICFFFAFKSRKLPENFTEAKFITFSMLIFFIVWISFIPAYFSTYGKFVSAVEVIAILASSFSLLACIFFNKVYIILLKPSRNTIEEVRCST | ||||||
Region | 890-939 | Disordered | ||||
Sequence: SSGFRKRSSSVGGSSASSPSSSISMKTNGNEMESPSTRRHGSKPRVSFGS | ||||||
Compositional bias | 892-939 | Polar residues | ||||
Sequence: GFRKRSSSVGGSSASSPSSSISMKTNGNEMESPSTRRHGSKPRVSFGS |
Sequence similarities
Belongs to the G-protein coupled receptor 3 family.
Keywords
- Domain
Family and domain databases
Protein family/group databases
Sequence
- Sequence statusComplete
- Length956
- Mass (Da)107,150
- Last updated2022-08-03 v1
- ChecksumC54DD4F25DE661E5
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8M1P4E9 | A0A8M1P4E9_DANRE | casr | 946 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 892-939 | Polar residues | ||||
Sequence: GFRKRSSSVGGSSASSPSSSISMKTNGNEMESPSTRRHGSKPRVSFGS |
Keywords
- Technical term