A0A8M6Z4R6 · A0A8M6Z4R6_DANRE

Function

Catalytic activity

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.
    EC:2.3.2.26 (UniProtKB | ENZYME | Rhea)

Pathway

Protein modification; protein ubiquitination.

Features

Showing features for active site.

112621002003004005006007008009001,0001,1001,200
TypeIDPosition(s)Description
Active site1230Glycyl thioester intermediate

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular Functionubiquitin-protein transferase activity
Biological Processprotein ubiquitination

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    HECT-type E3 ubiquitin transferase
  • EC number

Gene names

    • Name
      LOC103909792

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    A0A8M6Z4R6

Proteomes

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-21
ChainPRO_503543756122-1262HECT-type E3 ubiquitin transferase

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain1-108C2
Region160-249Disordered
Compositional bias172-249Polar residues
Domain260-293WW
Domain326-359WW
Region355-380Disordered
Compositional bias360-375Basic and acidic residues
Region539-626Disordered
Compositional bias551-626Polar residues
Region639-721Disordered
Domain690-723WW
Domain722-755WW
Domain797-830WW
Domain837-870WW
Domain928-1262HECT

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,262
  • Mass (Da)
    141,294
  • Last updated
    2022-08-03 v1
  • Checksum
    720815809BE60276
MLNVCVCVCVCVCVCVSVSCAKLKRKKNWFGTAVYVEVTSDGESRKTAKSHCVSSPKWEERLTLNIAPHAPLEFRVWSHHALKADALLGRAALDLIGTLRKHDGKLENVREVLPLTAEGKHGVVSTGELTVFLDGLSLDPQLLHSSNTPTASKVHQNGDALHEDADDSSARPQHRSVNGSDGAENEAPPTSSASSECRPSPLLNGDRDSSPSHQSPSPKATPSAQATPSTQATPPEQRASSSAAGESQVFTTESALTITELLENQWERRVDNRGRIYYVDHNTRTTTWQRPTMESVRNFEQWQSQRSQLQGAMHQFNQRYLLQNEDPLPEGWEIRYTREGVRYFVDHNTRTTTFSDPRTGKSAVEKRDNFPDSAEESGHLVHGQPSLRSHINRLTVVSTTTSANPPLSLCVRVCVCVCVCVCVCVCACVCVCVCVCVCVCVCRNIAPHAPLEFRVWSHHALKADALLGRAALDLIGTLRKHDGKLENVREVLPLTAEGKHGVVSTGELTVFLDGLSLDPQLLHSSNTPTASKVHQNGDALHEDADDSSARPQHRSVNGSDGAENEAPPTSSASSECRPSPLLNGDRDSSPSHQSPSPKATPSAQATPSTQATPPEQASSSAAVNGEASESACVGESAAADAPCSSSSSPAGGAAAAHTLSAADTHTPAAPSTPAPDGGKPAQQQPTGGVEPLPPGWEQRKDPHGRTYYVDHNTRTTTWERPQPLPLGWERRVDNRGRIYYVDHNTRTTTWQRPTMESVRNFEQWQSQRSQLQGAMHQFNQRYLYSASMMSAENDPLGPLPPGWERRVDTNDRVYFVNHNTKTTQWEDPRTQGLQNEDPLPEGWEIRYTREGVRYFVDHNTRTTTFSDPRTGKSAVTKGPQIAYERSFRWKLAHFRYLCQSNALASHVKITVSRQTLFEDSFQQIMNFKPYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKSNYCLQINPASTINPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLILKDLESIDPEFYNSLIWIRDNNIEECGLEMFFSVDMEILGKISSHDLKEDGANVQVTEENKEEYIGLMAEWRFSRGVESQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLQDWQRNTVYRHYTRNSKQIIWFWQLVKEVDNEVRLRLMQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSFEQLKEKLLFAIEETEGFGQE

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias172-249Polar residues
Compositional bias360-375Basic and acidic residues
Compositional bias551-626Polar residues

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

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