A0A8M6Z2H4 · A0A8M6Z2H4_DANRE
- ProteinE3 ubiquitin-protein ligase
- Geneubr2
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1770 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.
Catalytic activity
Pathway
Protein modification; protein ubiquitination.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | ubiquitin ligase complex | |
Molecular Function | ubiquitin protein ligase activity | |
Molecular Function | zinc ion binding | |
Biological Process | protein ubiquitination | |
Biological Process | ubiquitin-dependent protein catabolic process via the N-end rule pathway |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameE3 ubiquitin-protein ligase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionA0A8M6Z2H4
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for domain, zinc finger, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 99-170 | UBR-type | ||||
Sequence: QLCGHVFKVGEPTYSCRECAADPTCVLCMQCFLGSVHKEHRYRMTTSGGGGFCDCGDTEAWKKGPYCQKHEP | ||||||
Zinc finger | 99-170 | UBR-type | ||||
Sequence: QLCGHVFKVGEPTYSCRECAADPTCVLCMQCFLGSVHKEHRYRMTTSGGGGFCDCGDTEAWKKGPYCQKHEP | ||||||
Region | 1020-1051 | Disordered | ||||
Sequence: ECTASAPPSDSSGHSQEETVRDKEKAERKRKA | ||||||
Compositional bias | 1034-1051 | Basic and acidic residues | ||||
Sequence: SQEETVRDKEKAERKRKA | ||||||
Region | 1276-1307 | Disordered | ||||
Sequence: RKSKTSSAEAADETDGVNDCPPPDGFRLDHTP |
Sequence similarities
Belongs to the UBR1 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,770
- Mass (Da)200,521
- Last updated2022-08-03 v1
- ChecksumF4665BCDA6F8394C
Computationally mapped potential isoform sequences
There are 8 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8M6Z1W9 | A0A8M6Z1W9_DANRE | ubr2 | 1771 | ||
A0A8M9PML5 | A0A8M9PML5_DANRE | ubr2 | 546 | ||
A0A8M6Z9B0 | A0A8M6Z9B0_DANRE | ubr2 | 1771 | ||
A0A8M2B2K6 | A0A8M2B2K6_DANRE | ubr2 | 1757 | ||
A0A8M2B2U0 | A0A8M2B2U0_DANRE | ubr2 | 1756 | ||
A0A8M1QLF4 | A0A8M1QLF4_DANRE | ubr2 | 1756 | ||
A0A8M9PB10 | A0A8M9PB10_DANRE | ubr2 | 946 | ||
A0A8M6Z417 | A0A8M6Z417_DANRE | ubr2 | 1371 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1034-1051 | Basic and acidic residues | ||||
Sequence: SQEETVRDKEKAERKRKA |
Keywords
- Technical term