A0A8M6Z2H4 · A0A8M6Z2H4_DANRE

Function

function

Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.

Catalytic activity

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.
    EC:2.3.2.27 (UniProtKB | ENZYME | Rhea)

Pathway

Protein modification; protein ubiquitination.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentubiquitin ligase complex
Molecular Functionubiquitin protein ligase activity
Molecular Functionzinc ion binding
Biological Processprotein ubiquitination
Biological Processubiquitin-dependent protein catabolic process via the N-end rule pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    E3 ubiquitin-protein ligase
  • EC number

Gene names

    • Name
      ubr2

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    A0A8M6Z2H4

Proteomes

Organism-specific databases

Subcellular Location

Family & Domains

Features

Showing features for domain, zinc finger, region, compositional bias.

TypeIDPosition(s)Description
Domain99-170UBR-type
Zinc finger99-170UBR-type
Region1020-1051Disordered
Compositional bias1034-1051Basic and acidic residues
Region1276-1307Disordered

Sequence similarities

Belongs to the UBR1 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,770
  • Mass (Da)
    200,521
  • Last updated
    2022-08-03 v1
  • Checksum
    F4665BCDA6F8394C
MAAAETDRDAPSALCSEFLNFSAKDTAAKWLQVSNLPKEVYQHLACYVPKIYCLGPNLNPQNEDLLAQLLLQGPLEWYLCGEEPSVGLSKLEQNNQPSQLCGHVFKVGEPTYSCRECAADPTCVLCMQCFLGSVHKEHRYRMTTSGGGGFCDCGDTEAWKKGPYCQKHEPNISDSSQKDPLANLSAEMIARTYNVFSIILKYAVDMLTWDKEDELPEGLEPPARGDMYYCMLFNDEVHTYEQVIYTLQKAVNCTQKEAVSFATTVDRDGRKSVRFGDFQFCEQAKSVIVVNTLQSTSTKPLAWRNTSRQTKPLRVQVMHSSVVAHQCFALKALNWLGQTIRYSDALRRILCQVGLQRGPEGENSSLVDKLMLCDSKMWKGARNVYHQLFMSSLLMDPKYKKLFAIQFARNYERLQSDYVKDDHDREFSVTDLSVQMFTVPSLARMLITDENLMTTIIRTFVDHLRHRDLQGRFQFERYTAQQAFKFRRVQSLIGDLKYVLISRPTEWTDQLREKYLEGFDAFLELLKCMQGMDPVVRQVGQHIEMEPEWEAAFTLQMKLTHIISMMQEWCASDERVLIEAYKKSLSALTHCHSGFTDGEQPITLSMCGHSVDTIRYCVSQEKVSIHLPVSRLLAGLHALLSKIEVAYRFPEQLPLSELSPPMLIEHPLRCLVLCAQVHAGMWRRNGFSLVNQIYYYHNVKCRVEMFDKDLIMLQAGASMMDPNHFLMIMLSRFELYHIFSSADCRKRYSRENANKDVVQQNNTLIEEMLHLIIMIVGERYTAGVGQVEITDEIRREIVHQLCIRPMAHSELVKALPENENKETGMERVIDSVALFKKPGVTGRGLYKLRPECAKMFNLYFHHYSRADQSKAEEAQRKIKRQNGEDSVLPPPVLPRFCPLFASLVNILQCDVLLGILGAVLQWAMEPSGGHWSESMLQRVLHLIGMGLVEEQQHLISSAEDYNDTNFNFTLKISRPGEAPANTASILALLETLQNAPHLEVHKDMIRWILKTVAYIKTTRECTASAPPSDSSGHSQEETVRDKEKAERKRKAEMARLRREKIMAQMSEMQRHFINENKELFQQSLEDLDPSTSSTLEHSPSSCDSALVCVGPRRWRAGGSDRRQVVTCILCQEEQEIRSDGKAMVLAAFVQRSTVMSKNRKRPPHNPDKYDPLFMHPDLSFGTHTGSCGHIMHSHCWQRYFEAVQAKEQRRQQRLRVHTSYDVENGEFLCPLCECLSNTVIPLLPLTKTCCSSEQPDLSQWLNITSHQMKALISAHRKSKTSSAEAADETDGVNDCPPPDGFRLDHTPKNPYSSTIKEMLTTFGTATYKVGLKVHPNEQDPRVPIMCWGSCAYTIQSIERLLVDEEKPLFGSLPCRQDDCLSSLTRFGSACWTVSSHTTVQNHFIRLLAALVPDPRVENTPCILDVDMFHLLVSLVLSHPAVLCLDSSGLSADAAQLHFLHLITVAHVVQILLTSLPEEVRMEQETGGAEREEEESVCLLYNTLRSLLGRGLREVSSGWHLWRCVKAGILPYLRAAALFFHYLNGAPAPPELHALGAGEWEALCGYLCLPSNLLQLYFNNLDIMEPLLHGWCSHPALQALQSSVTLIRFPRESNHLIDLPGDYSALINQASSFTCPKSGGDKSRVPTLCLVCGAMLCSQSYCCQTELEGEDVGACTAHTFTCGAGVGIFLRVRESQVLFLAGKTKGCFYAPPYLDDYGETDQGLRRGNPLHLCHERYRKIQKLWRQHSITEEIGHAQEANQTLVGIDWQHL

Computationally mapped potential isoform sequences

There are 8 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8M6Z1W9A0A8M6Z1W9_DANREubr21771
A0A8M9PML5A0A8M9PML5_DANREubr2546
A0A8M6Z9B0A0A8M6Z9B0_DANREubr21771
A0A8M2B2K6A0A8M2B2K6_DANREubr21757
A0A8M2B2U0A0A8M2B2U0_DANREubr21756
A0A8M1QLF4A0A8M1QLF4_DANREubr21756
A0A8M9PB10A0A8M9PB10_DANREubr2946
A0A8M6Z417A0A8M6Z417_DANREubr21371

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1034-1051Basic and acidic residues

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

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