A0A8M6Z0Q7 · A0A8M6Z0Q7_DANRE
- ProteinPro-neuregulin-1, membrane-bound isoform isoform X7
- Genenrg1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids412 (go to sequence)
- Protein existencePredicted
- Annotation score5/5
Publications for A0A8M6Z0Q7
Unmyelinated sensory neurons use Neuregulin signals to promote myelination of interneurons in the CNS.
- CategoryPhenotypes & Variants
- SourceZFIN: ZDB-GENE-050302-113
NRG1/ErbB signalling controls the dialogue between macrophages and neural crest-derived cells during zebrafish fin regeneration.
- AnnotationNRG1/ErbB signalling controls the dialogue between macrophages and neural crest-derived cells during zebrafish fin regeneration.
- CategoriesFunction, Expression
- SourceGeneRif: 796461
A subset of SMN complex members have a specific role in tissue regeneration via ERBB pathway-mediated proliferation.
- CategoryPhenotypes & Variants
- SourceZFIN: ZDB-GENE-050302-113
The Paf1 complex and P-TEFb have reciprocal and antagonist roles in maintaining multipotent neural crest progenitors.
- CategoryPhenotypes & Variants
- SourceZFIN: ZDB-GENE-050302-113
The zinc finger protein Zfpm1 modulates ventricular trabeculation through Neuregulin-ErbB signalling.
- AnnotationLoss of zinc finger protein multitype 1 (Zfpm1) activity resulted in over-activation of Neuregulin-ErbB signaling and abnormally elevated cardiomyocyte proliferation.
- CategoryFunction
- SourceGeneRif: 796461
Neuregulin-1 is essential for nerve plexus formation during cardiac maturation.
- AnnotationNeuregulin-1 is essential for nerve plexus formation during cardiac maturation.
- CategoriesFunction, Phenotypes & Variants
- SourceGeneRif: 796461, ZFIN: ZDB-GENE-050302-113
Neuregulin 1 is involved in enteric nervous system development in zebrafish.
- CategoryPhenotypes & Variants
- SourceZFIN: ZDB-GENE-050302-113
In Vivo Visualization of Cardiomyocyte Apicobasal Polarity Reveals Epithelial to Mesenchymal-like Transition during Cardiac Trabeculation.
- Annotationwe observed the activation of Notch signaling in cardiomyocytes adjacent to those undergoing apical constriction and we showed that this activation is positively regulated by Neuregulin signaling.
- CategoryFunction
- SourceGeneRif: 796461
IgG-Containing Isoforms of Neuregulin-1 Are Dispensable for Cardiac Trabeculation in Zebrafish.
- Annotationthese results suggest that Nrg1 is not the primary effector of trabeculation and/or that other EGF-like ligand(s) activates the ErbB2/ErbB4 pathway either through functioning as the primary ligand or acting in a redundant manner. Overall our work provides an example of cross-species differences in EGF family member requirements for an evolutionary conserved process.
- CategoriesFunction, Phenotypes & Variants
- SourceGeneRif: 796461, ZFIN: ZDB-GENE-050302-113
Cardiac contraction activates endocardial Notch signaling to modulate chamber maturation in zebrafish.
- AnnotationNotch1 activation induces expression of ephrin b2a (efnb2a) and neuregulin 1 (nrg1) in the endocardium to promote trabeculation and forced Notch activation in the absence of cardiac contraction rescues efnb2a and nrg1 expression
- CategoryFunction
- SourceGeneRif: 796461
Nrg1 is an injury-induced cardiomyocyte mitogen for the endogenous heart regeneration program in zebrafish.
- AnnotationThese findings identify Nrg1 as a potent induced mitogen for the endogenous adult heart regeneration program.
- CategoriesFunction, Expression
- SourceGeneRif: 796461
Mapped toErbB expressing Schwann cells control lateral line progenitor cells via non-cell-autonomous regulation of Wnt/beta-catenin.
- CategoryPhenotypes & Variants
- SourceZFIN: ZDB-GENE-050302-113
Neuronal Neuregulin 1 type III directs Schwann cell migration.
- AnnotationThese results demonstrate that Nrg1 type III is an essential signal that controls Schwann cell migration to ensure that these glia are present in the correct numbers and positions in developing nerves.
- CategoryFunction, Phenotypes & Variants
- SourceGeneRif: 796461, ZFIN: ZDB-GENE-050302-113
ErbB2 and ErbB3 regulate amputation-induced proliferation and migration during vertebrate regeneration.
- AnnotationNRG1 and PI3K functionally interact with ErbB2 and ErbB3 during regeneration
- CategoryFunction, Phenotypes & Variants
- SourceGeneRif: 796461, ZFIN: ZDB-GENE-050302-113
Disrupted-in-schizophrenia 1 and neuregulin 1 are required for the specification of oligodendrocytes and neurones in the zebrafish brain.
- AnnotationDisc1 and nrg1 function in controlling development of oligodendrocytes and neurones from olig2-expressing precursor cells.
- CategoriesFunction, Phenotypes & Variants
- SourceGeneRif: 796461, ZFIN: ZDB-GENE-050302-113
Neuregulin-mediated ErbB3 signaling is required for formation of zebrafish dorsal root ganglion neurons.
- AnnotationErbB3 signaling is required for normal migration of trunk but not cranial neural crest cells
- CategoryFunction, Phenotypes & Variants
- SourceGeneRif: 796461, ZFIN: ZDB-GENE-050302-113