A0A8M3B8D7 · A0A8M3B8D7_DANRE

Function

Catalytic activity

Features

Showing features for binding site.

123572004006008001,0001,2001,4001,6001,8002,0002,200
TypeIDPosition(s)Description
Binding site309Ca2+ (UniProtKB | ChEBI)
Binding site652Ca2+ (UniProtKB | ChEBI)
Binding site1362Ca2+ (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentneuronal cell body
Cellular Componentsynapse
Cellular Componentvoltage-gated calcium channel complex
Molecular Functionhigh voltage-gated calcium channel activity
Molecular Functionmetal ion binding
Biological Processcalcium ion import across plasma membrane
Biological Processchemical synaptic transmission

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Voltage-dependent P/Q-type calcium channel subunit alpha-1A
  • Alternative names
    • Voltage-gated calcium channel subunit alpha Cav2.1

Gene names

    • Name
      cacna1aa

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    A0A8M3B8D7

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane93-110Helical
Transmembrane131-152Helical
Transmembrane164-184Helical
Transmembrane219-242Helical
Transmembrane295-316Helical
Transmembrane328-350Helical
Transmembrane472-491Helical
Transmembrane503-523Helical
Transmembrane598-620Helical
Transmembrane673-698Helical
Transmembrane1140-1159Helical
Transmembrane1179-1200Helical
Transmembrane1212-1230Helical
Transmembrane1278-1300Helical
Transmembrane1391-1416Helical
Transmembrane1470-1487Helical
Transmembrane1499-1525Helical
Transmembrane1594-1612Helical
Transmembrane1684-1708Helical

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for glycosylation.

TypeIDPosition(s)Description
Glycosylation274N-linked (GlcNAc...) asparagine

Keywords

Family & Domains

Features

Showing features for region, coiled coil, compositional bias, domain.

TypeIDPosition(s)Description
Region1-41Disordered
Coiled coil694-721
Region816-1000Disordered
Compositional bias829-859Polar residues
Compositional bias890-904Basic and acidic residues
Compositional bias915-977Basic and acidic residues
Compositional bias978-1000Polar residues
Region1084-1117Disordered
Domain1849-1883Voltage-dependent calcium channel alpha-1 subunit IQ
Region1890-1918Disordered
Region1940-1962Disordered
Region1990-2357Disordered
Compositional bias1999-2015Polar residues
Compositional bias2024-2046Basic and acidic residues
Compositional bias2063-2083Polar residues
Compositional bias2093-2110Basic residues
Compositional bias2111-2145Basic and acidic residues
Compositional bias2146-2186Polar residues
Compositional bias2218-2234Pro residues
Compositional bias2277-2302Polar residues

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,357
  • Mass (Da)
    267,694
  • Last updated
    2022-08-03 v1
  • Checksum
    1656B3BE55487601
MARFGDEVPSRYGGGPGHAQGGPGRGGSRQGGPPGAQQRMYKQSMAQRARTMALYNPIPVRQNCFTVNRSLFIFSEDNFVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLEDTEPYFIGIFCFESGIKILALGFAFHKGSYLRNGWNVMDFVVVLTGILSTVGSDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILMFAIIGLEFYMGKFHTTCFDKITDEIREEFPCGEEVPARICPNGTVCKKYWLGPNYGITQFDNILFAVLTVFQCITMEGWTDLLYYSNDAAGSAWNWMYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRSEFLKLKRQQQIERELNGYLEWICKAEEVILADEDNDPDDRMPFDGSRRRPTIKKSKTDLLDAEDGDGDIGSPFARGSLKSSKLEGSSFHKKERRLRFFIRRIVKTQAFYWTVLCLVGLNTLCVAVVHYDQPETLSDFLYFAEFIFLGIFMSEMCIKMYGLGTRPYFHSSFNCFDCIVICGSIFEVLWAMIQPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFEAGTPPTNFDTFPAAIMTVFQILTGEDWNMVMYDGIESQGGVKKGMVFSVFFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEQAANKKMALQTAKEVAEVSPLSAANLSIAAVTVNSERLDATEHFLDCKEQQKNHKGCKSVWEQRTSELRRQTLVNSREALYNELDPEDRWKVSYSRHIRPDMKTHLDRPLVVDPQENRNNNTNKTRPGDGQPQHSHQLLHKQPNFNEAETGGGGGSESWPALERGDSTGSRRSLLGSEHYEEGRESHRRHQHSQHCSQARQHRKAAEGGGEPGGRRHRSKAKERGPECEHSDGGERKHRRHRHEGEGRKERGVRHRNRRDGHASGPTLSTTRPIQKTLSRQDSQYSEDLDNAMNNKLATQPHDSLLNLANTAHSAGLAHTGTESSLILTNPSSTIANVTSIGHLGMKPEYTAVDIPPMFPSSNAILQVNKNANTEPLPKKEDTKGDDDDDEKDDGGPKPMPPYTSMFILTTTNPFRRLCHYIVTLRYFEMCILLVIAMSSIALAAEDPVWPESPRNNVLRYFDYVFTGVFTFEMLIKMVDLGLVLHQGSYFRDLWNILDFIVVSGALVAFAFTGGSGGSSKGKDISTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVVAVQLFKGRFFYCTDESKEFERDCRGEYLVYERDNEVRSQKREWKKYDFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATYENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEDYSLEKNERACIDFAINAKPLTRHMPQNKQTFQYRMWEFVVSPPFEYTIMALIALNTIVLMMKYDGASLTYEDVLKYLNIVFTSLFSMECILKIIAFGALNYFKDAWNIFDCVTVLGSITDILVTELGMNNFINLSFLRLFRAARLIKLLRQGETIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQLFGNIKIEENSDSAITQHNNFRTFFQALMLLFRSATGEAWHDIMLSCLGKKPCDILSDNPKPECGSEFAYLYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRIWAEYDPAACGRIHYKDMYSLLRVIDPPLGLGKKCPHRVACKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGEGGVDKHQMDAELRKEMMAIWPNLSQKNLDLLVTPHKSATDLTVGKIYAAMMIMEYYRQSKAKRTQALHDEQNRTPLMFQRLEPPSPSQDVGPGLTGLPDTQMHPANHLPVDERIPESQSWVTARAQEISQKAGNWSPEGQHPDDTTDNRRQSQTVEMREMGRDGYSDTEQYLPMEGHGRAASMPRLPADNQQPITDNSPMKRSASSLGHGRAGRSMRGEDYAMERVIPEEGHRHGHRHRDRSHRASERSLSRYTDADTGLGTDLSTTTQSGDLPSKERDRGRAKDRKHHHHHHHHHGSLDKEHYGHERDRGEYGHRQSRERDRRWSRSPSEGRECLTHRQGSSSVSGSPVPSTSGTSTPRRGRRQLPQTPATPRPHVTYSPVVRKPISSTPPPGQQSRLPTPTSRRFSPTGPEPPLPPHHHPSPPHHGSPRSGRHAHWGPEPAESVEGDGFYDDQDYEFNHHEPPSYEQSPVQGNPHPHSPRTSRHNTPPQGQAHPRRMPNGYRSSSPSPHHHAPAHPGTHKPPHPRGPRKGLHEPYSETDEDDWC

Computationally mapped potential isoform sequences

There are 27 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8M9PFQ8A0A8M9PFQ8_DANREcacna1aa2371
A0A8M9PSS2A0A8M9PSS2_DANREcacna1aa2366
A0A8M9Q515A0A8M9Q515_DANREcacna1aa2370
A0A8M9PSR1A0A8M9PSR1_DANREcacna1aa2368
A0A8M9PSR6A0A8M9PSR6_DANREcacna1aa2367
A0A8M9PSS9A0A8M9PSS9_DANREcacna1aa2362
A0A8M9Q509A0A8M9Q509_DANREcacna1aa2370
A0A8M9PSU9A0A8M9PSU9_DANREcacna1aa2332
A0A8M9PSV7A0A8M9PSV7_DANREcacna1aa2319
A0A8M9PSW2A0A8M9PSW2_DANREcacna1aa2165
A0A8M9Q554A0A8M9Q554_DANREcacna1aa2344
A0A8M9PYT6A0A8M9PYT6_DANREcacna1aa2367
A0A8M9PYU4A0A8M9PYU4_DANREcacna1aa2363
A0A8M9PYS3A0A8M9PYS3_DANREcacna1aa2370
A0A8M3B129A0A8M3B129_DANREcacna1aa2310
A0A8M9Q9N8A0A8M9Q9N8_DANREcacna1aa2371
A0A8M9Q9T2A0A8M9Q9T2_DANREcacna1aa2354
A0A8M9Q9Q4A0A8M9Q9Q4_DANREcacna1aa2368
A0A8M9Q9V1A0A8M9Q9V1_DANREcacna1aa1615
A0A8M3AR05A0A8M3AR05_DANREcacna1aa2318
A0A8M3AY50A0A8M3AY50_DANREcacna1aa2293
A0A8M2BBB9A0A8M2BBB9_DANREcacna1aa1740
A0A8M6Z5Q8A0A8M6Z5Q8_DANREcacna1aa2356
A0A8M9PFV0A0A8M9PFV0_DANREcacna1aa2333
A0A8M9PFV9A0A8M9PFV9_DANREcacna1aa2307
A0A8M9PFW8A0A8M9PFW8_DANREcacna1aa2344
A0A8M9PFU0A0A8M9PFU0_DANREcacna1aa2362

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias829-859Polar residues
Compositional bias890-904Basic and acidic residues
Compositional bias915-977Basic and acidic residues
Compositional bias978-1000Polar residues
Compositional bias1999-2015Polar residues
Compositional bias2024-2046Basic and acidic residues
Compositional bias2063-2083Polar residues
Compositional bias2093-2110Basic residues
Compositional bias2111-2145Basic and acidic residues
Compositional bias2146-2186Polar residues
Compositional bias2218-2234Pro residues
Compositional bias2277-2302Polar residues

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

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