A0A8M3B1T9 · A0A8M3B1T9_DANRE
- ProteinPro-neuregulin-1, membrane-bound isoform isoform X1
- Genenrg1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids729 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | extracellular space | |
Cellular Component | plasma membrane | |
Molecular Function | chemorepellent activity | |
Molecular Function | growth factor activity | |
Molecular Function | protein tyrosine kinase activator activity | |
Biological Process | animal organ development | |
Biological Process | cardiac neuron development | |
Biological Process | cell differentiation | |
Biological Process | enteric nervous system development | |
Biological Process | eurydendroid cell differentiation | |
Biological Process | fin regeneration | |
Biological Process | generation of neurons | |
Biological Process | intracellular signal transduction | |
Biological Process | nervous system development | |
Biological Process | neural crest cell migration | |
Biological Process | oligodendrocyte cell fate specification | |
Biological Process | peripheral nervous system development | |
Biological Process | Schwann cell development | |
Biological Process | Schwann cell migration | |
Biological Process | ventricular trabecula myocardium morphogenesis |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionA0A8M3B1T9
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type I membrane protein
Membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 340-362 | Helical | ||||
Sequence: VLTITGICIALLVVGIMCVVAYC |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Disulfide bond | 305↔314 | |||||
Sequence: CPNEFTGDRC |
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 161-254 | Ig-like | ||||
Sequence: PKLKNLRSVTVEDGKKTVLKCEILAGNPAPNVKWYKNGKELTGKNKPKSIKIKKKKQGKISELLIRKSTEGDAGLYTCEAVNSLGKTNTTANLF | ||||||
Domain | 271-315 | EGF-like | ||||
Sequence: HVTPCNESEKEYCVNHGKCFTLEVTPGNIRRLCRCPNEFTGDRCQ | ||||||
Region | 426-445 | Disordered | ||||
Sequence: TNEFTSPTHPSTAITHSSSQ | ||||||
Compositional bias | 523-559 | Polar residues | ||||
Sequence: RLSPVGLLSPVTPSSPPSEMSAPLSSLATSVPSMLTS | ||||||
Region | 523-613 | Disordered | ||||
Sequence: RLSPVGLLSPVTPSSPPSEMSAPLSSLATSVPSMLTSPSGEEERPLLFRTPPILRDKSASTQGRKSGHNLRNSAHYNHGLDIPSPPPSPLH | ||||||
Compositional bias | 577-595 | Polar residues | ||||
Sequence: RDKSASTQGRKSGHNLRNS | ||||||
Compositional bias | 625-663 | Polar residues | ||||
Sequence: KSTSVPSSAPHSPSAARTQPSGQAAPEQAVSGSNSESSS | ||||||
Region | 625-682 | Disordered | ||||
Sequence: KSTSVPSSAPHSPSAARTQPSGQAAPEQAVSGSNSESSSSESETEDERVGEDTPFLGL |
Sequence similarities
Belongs to the neuregulin family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length729
- Mass (Da)79,611
- Last updated2022-08-03 v1
- Checksum1939ED67371B7769
Computationally mapped potential isoform sequences
There are 11 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A0R4IBM0 | A0A0R4IBM0_DANRE | nrg1 | 730 | ||
A0A8M3B1W6 | A0A8M3B1W6_DANRE | nrg1 | 724 | ||
A0A0R4IPH3 | A0A0R4IPH3_DANRE | nrg1 | 722 | ||
A0A0R4IDP7 | A0A0R4IDP7_DANRE | nrg1 | 725 | ||
A0A1B4Z255 | A0A1B4Z255_DANRE | nrg1 | 604 | ||
A0A8M3B955 | A0A8M3B955_DANRE | nrg1 | 692 | ||
A0A0R4IFE6 | A0A0R4IFE6_DANRE | nrg1 | 687 | ||
B3DK99 | B3DK99_DANRE | nrg1 | 599 | ||
A0A8M9QGQ0 | A0A8M9QGQ0_DANRE | nrg1 | 404 | ||
A0A8M6Z0Q7 | A0A8M6Z0Q7_DANRE | nrg1 | 412 | ||
A0A8M9QKS2 | A0A8M9QKS2_DANRE | nrg1 | 417 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 523-559 | Polar residues | ||||
Sequence: RLSPVGLLSPVTPSSPPSEMSAPLSSLATSVPSMLTS | ||||||
Compositional bias | 577-595 | Polar residues | ||||
Sequence: RDKSASTQGRKSGHNLRNS | ||||||
Compositional bias | 625-663 | Polar residues | ||||
Sequence: KSTSVPSSAPHSPSAARTQPSGQAAPEQAVSGSNSESSS |
Keywords
- Technical term