A0A8M3B129 · A0A8M3B129_DANRE
- ProteinVoltage-dependent P/Q-type calcium channel subunit alpha-1A
- Genecacna1aa
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids2310 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- Ca2+(in) = Ca2+(out)
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | neuronal cell body | |
Cellular Component | synapse | |
Cellular Component | voltage-gated calcium channel complex | |
Molecular Function | high voltage-gated calcium channel activity | |
Molecular Function | metal ion binding | |
Biological Process | calcium ion import across plasma membrane | |
Biological Process | chemical synaptic transmission |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameVoltage-dependent P/Q-type calcium channel subunit alpha-1A
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionA0A8M3B129
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 93-110 | Helical | ||||
Sequence: FEYMILATIIANCIVLAL | ||||||
Transmembrane | 131-152 | Helical | ||||
Sequence: PYFIGIFCFESGIKILALGFAF | ||||||
Transmembrane | 164-184 | Helical | ||||
Sequence: VMDFVVVLTGILSTVGSDFDL | ||||||
Transmembrane | 219-242 | Helical | ||||
Sequence: LLQIGLLLFFAILMFAIIGLEFYM | ||||||
Transmembrane | 295-316 | Helical | ||||
Sequence: ILFAVLTVFQCITMEGWTDLLY | ||||||
Transmembrane | 328-350 | Helical | ||||
Sequence: WMYFIPLIIIGSFFMLNLVLGVL | ||||||
Transmembrane | 472-491 | Helical | ||||
Sequence: AFYWTVLCLVGLNTLCVAVV | ||||||
Transmembrane | 503-523 | Helical | ||||
Sequence: LYFAEFIFLGIFMSEMCIKMY | ||||||
Transmembrane | 535-555 | Helical | ||||
Sequence: FNCFDCIVICGSIFEVLWAMI | ||||||
Transmembrane | 598-620 | Helical | ||||
Sequence: IISLLFLLFLFIVVFALLGMQLF | ||||||
Transmembrane | 673-698 | Helical | ||||
Sequence: VFSVFFIVLTLFGNYTLLNVFLAIAV | ||||||
Transmembrane | 1140-1159 | Helical | ||||
Sequence: LRYFEMCILLVIAMSSIALA | ||||||
Transmembrane | 1179-1200 | Helical | ||||
Sequence: YVFTGVFTFEMLIKMVDLGLVL | ||||||
Transmembrane | 1212-1230 | Helical | ||||
Sequence: ILDFIVVSGALVAFAFTGS | ||||||
Transmembrane | 1274-1296 | Helical | ||||
Sequence: VLNILIVYMLFMFIFAVVAVQLF | ||||||
Transmembrane | 1387-1412 | Helical | ||||
Sequence: IFYVVYFVVFPFFFVNIFVALIIITF | ||||||
Transmembrane | 1466-1483 | Helical | ||||
Sequence: FEYTIMALIALNTIVLMM | ||||||
Transmembrane | 1495-1521 | Helical | ||||
Sequence: VLKYLNIVFTSLFSMECILKIIAFGAL | ||||||
Transmembrane | 1589-1607 | Helical | ||||
Sequence: ALPYVCLLIAMLFFIYAII | ||||||
Transmembrane | 1679-1703 | Helical | ||||
Sequence: AYLYFVSFIFLCSFLMLNLFVAVIM |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Glycosylation | 274 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for region, coiled coil, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-41 | Disordered | ||||
Sequence: MARFGDEVPSRYGGGPGHAQGGPGRGGSRQGGPPGAQQRMY | ||||||
Coiled coil | 694-721 | |||||
Sequence: LAIAVDNLANAQELTKDEQEEEQAANKK | ||||||
Region | 816-1000 | Disordered | ||||
Sequence: DMKTHLDRPLVVDPQENRNNNTNKTRPGDGQPQHSHQLLHKQPNFNEAETGGGGGSESWPALERGDSTGSRRSLLGSEHYEEGRESHRRHQHSQHCSQARQHRKAAEGGGEPGGRRHRSKAKERGPECEHSDGGERKHRRHRHEGEGRKERGVRHRNRRDGHASGPTLSTTRPIQKTLSRQDSQY | ||||||
Compositional bias | 829-859 | Polar residues | ||||
Sequence: PQENRNNNTNKTRPGDGQPQHSHQLLHKQPN | ||||||
Compositional bias | 890-904 | Basic and acidic residues | ||||
Sequence: LGSEHYEEGRESHRR | ||||||
Compositional bias | 915-977 | Basic and acidic residues | ||||
Sequence: RQHRKAAEGGGEPGGRRHRSKAKERGPECEHSDGGERKHRRHRHEGEGRKERGVRHRNRRDGH | ||||||
Compositional bias | 978-1000 | Polar residues | ||||
Sequence: ASGPTLSTTRPIQKTLSRQDSQY | ||||||
Region | 1084-1117 | Disordered | ||||
Sequence: NKNANTEPLPKKEDTKGDDDDDEKDDGGPKPMPP | ||||||
Domain | 1841-1875 | Voltage-dependent calcium channel alpha-1 subunit IQ | ||||
Sequence: ATDLTVGKIYAAMMIMEYYRQSKAKRTQALHDEQN | ||||||
Region | 1882-1910 | Disordered | ||||
Sequence: QRLEPPSPSQDVGPGLTGLPDTQMHPANH | ||||||
Region | 1932-2310 | Disordered | ||||
Sequence: SQKAGNWSPEGQHPDDTTDNRRQSQPITDNSPMKRSASSLGHGRAGRSMRGEDYAMERVIPEEGHRHGHRHRDRSHRASERSLSRYTDADTGLGTDLSTTTQSGDLPSKERDRGRAKDRKHHHHHHHHHGSLDKEHYGHERDRGEYGHRQSRERDRRWSRSPSEGRECLTHRQGSSSVSGSPVPSTSGTSTPRRGRRQLPQTPATPRPHVTYSPVVRKPISSTPPPGQQSRLPTPTSRRFSPTGPEPPLPPHHHPSPPHHGSPRSGRHAHWGPEPAESVEGDGFYDDQDYEFNHHEPPSYEQSPVQGNPHPHSPRTSRHNTPPQGQAHPRRMPNGYRSSSPSPHHHAPAHPGTHKPPHPRGPRKGLHEPYSETDEDDWC | ||||||
Compositional bias | 1954-1968 | Polar residues | ||||
Sequence: QSQPITDNSPMKRSA | ||||||
Compositional bias | 1977-1999 | Basic and acidic residues | ||||
Sequence: GRSMRGEDYAMERVIPEEGHRHG | ||||||
Compositional bias | 2016-2036 | Polar residues | ||||
Sequence: RYTDADTGLGTDLSTTTQSGD | ||||||
Compositional bias | 2046-2063 | Basic residues | ||||
Sequence: RAKDRKHHHHHHHHHGSL | ||||||
Compositional bias | 2064-2098 | Basic and acidic residues | ||||
Sequence: DKEHYGHERDRGEYGHRQSRERDRRWSRSPSEGRE | ||||||
Compositional bias | 2099-2139 | Polar residues | ||||
Sequence: CLTHRQGSSSVSGSPVPSTSGTSTPRRGRRQLPQTPATPRP | ||||||
Compositional bias | 2171-2187 | Pro residues | ||||
Sequence: FSPTGPEPPLPPHHHPS | ||||||
Compositional bias | 2230-2255 | Polar residues | ||||
Sequence: SYEQSPVQGNPHPHSPRTSRHNTPPQ |
Sequence similarities
Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1A subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,310
- Mass (Da)262,654
- Last updated2022-08-03 v1
- ChecksumEEFCE287E77B6F2D
Computationally mapped potential isoform sequences
There are 27 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8M9PFQ8 | A0A8M9PFQ8_DANRE | cacna1aa | 2371 | ||
A0A8M9PSS2 | A0A8M9PSS2_DANRE | cacna1aa | 2366 | ||
A0A8M9Q515 | A0A8M9Q515_DANRE | cacna1aa | 2370 | ||
A0A8M9PSR1 | A0A8M9PSR1_DANRE | cacna1aa | 2368 | ||
A0A8M9PSR6 | A0A8M9PSR6_DANRE | cacna1aa | 2367 | ||
A0A8M9PSS9 | A0A8M9PSS9_DANRE | cacna1aa | 2362 | ||
A0A8M9Q509 | A0A8M9Q509_DANRE | cacna1aa | 2370 | ||
A0A8M9PSU9 | A0A8M9PSU9_DANRE | cacna1aa | 2332 | ||
A0A8M9PSV7 | A0A8M9PSV7_DANRE | cacna1aa | 2319 | ||
A0A8M9PSW2 | A0A8M9PSW2_DANRE | cacna1aa | 2165 | ||
A0A8M9Q554 | A0A8M9Q554_DANRE | cacna1aa | 2344 | ||
A0A8M9PYT6 | A0A8M9PYT6_DANRE | cacna1aa | 2367 | ||
A0A8M9PYU4 | A0A8M9PYU4_DANRE | cacna1aa | 2363 | ||
A0A8M9PYS3 | A0A8M9PYS3_DANRE | cacna1aa | 2370 | ||
A0A8M9Q9N8 | A0A8M9Q9N8_DANRE | cacna1aa | 2371 | ||
A0A8M9Q9T2 | A0A8M9Q9T2_DANRE | cacna1aa | 2354 | ||
A0A8M9Q9Q4 | A0A8M9Q9Q4_DANRE | cacna1aa | 2368 | ||
A0A8M9Q9V1 | A0A8M9Q9V1_DANRE | cacna1aa | 1615 | ||
A0A8M3AR05 | A0A8M3AR05_DANRE | cacna1aa | 2318 | ||
A0A8M3AY50 | A0A8M3AY50_DANRE | cacna1aa | 2293 | ||
A0A8M3B8D7 | A0A8M3B8D7_DANRE | cacna1aa | 2357 | ||
A0A8M2BBB9 | A0A8M2BBB9_DANRE | cacna1aa | 1740 | ||
A0A8M6Z5Q8 | A0A8M6Z5Q8_DANRE | cacna1aa | 2356 | ||
A0A8M9PFV0 | A0A8M9PFV0_DANRE | cacna1aa | 2333 | ||
A0A8M9PFV9 | A0A8M9PFV9_DANRE | cacna1aa | 2307 | ||
A0A8M9PFW8 | A0A8M9PFW8_DANRE | cacna1aa | 2344 | ||
A0A8M9PFU0 | A0A8M9PFU0_DANRE | cacna1aa | 2362 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 829-859 | Polar residues | ||||
Sequence: PQENRNNNTNKTRPGDGQPQHSHQLLHKQPN | ||||||
Compositional bias | 890-904 | Basic and acidic residues | ||||
Sequence: LGSEHYEEGRESHRR | ||||||
Compositional bias | 915-977 | Basic and acidic residues | ||||
Sequence: RQHRKAAEGGGEPGGRRHRSKAKERGPECEHSDGGERKHRRHRHEGEGRKERGVRHRNRRDGH | ||||||
Compositional bias | 978-1000 | Polar residues | ||||
Sequence: ASGPTLSTTRPIQKTLSRQDSQY | ||||||
Compositional bias | 1954-1968 | Polar residues | ||||
Sequence: QSQPITDNSPMKRSA | ||||||
Compositional bias | 1977-1999 | Basic and acidic residues | ||||
Sequence: GRSMRGEDYAMERVIPEEGHRHG | ||||||
Compositional bias | 2016-2036 | Polar residues | ||||
Sequence: RYTDADTGLGTDLSTTTQSGD | ||||||
Compositional bias | 2046-2063 | Basic residues | ||||
Sequence: RAKDRKHHHHHHHHHGSL | ||||||
Compositional bias | 2064-2098 | Basic and acidic residues | ||||
Sequence: DKEHYGHERDRGEYGHRQSRERDRRWSRSPSEGRE | ||||||
Compositional bias | 2099-2139 | Polar residues | ||||
Sequence: CLTHRQGSSSVSGSPVPSTSGTSTPRRGRRQLPQTPATPRP | ||||||
Compositional bias | 2171-2187 | Pro residues | ||||
Sequence: FSPTGPEPPLPPHHHPS | ||||||
Compositional bias | 2230-2255 | Polar residues | ||||
Sequence: SYEQSPVQGNPHPHSPRTSRHNTPPQ |
Keywords
- Technical term