A0A8M3AXY5 · A0A8M3AXY5_DANRE
- Proteinhistone acetyltransferase
- Geneep300b
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids2645 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
Catalytic activity
- (S)-lactoyl-CoA + L-lysyl-[protein] = N6-[(S)-lactoyl]-L-lysyl-[protein] + CoA + H+This reaction proceeds in the forward direction.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | histone acetyltransferase complex | |
Cellular Component | nucleoplasm | |
Cellular Component | transcription regulator complex | |
Molecular Function | chromatin DNA binding | |
Molecular Function | DNA-binding transcription factor binding | |
Molecular Function | histone acetyltransferase activity | |
Molecular Function | protein-containing complex binding | |
Molecular Function | transcription coactivator activity | |
Molecular Function | zinc ion binding | |
Biological Process | embryonic cranial skeleton morphogenesis | |
Biological Process | heart looping | |
Biological Process | pectoral fin development | |
Biological Process | positive regulation of transcription by RNA polymerase II | |
Biological Process | rhythmic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namehistone acetyltransferase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionA0A8M3AXY5
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain, zinc finger.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-37 | Disordered | ||||
Sequence: MADNVLDSGPPTAKRPKLSSPALSVSASDGNDFGSLF | ||||||
Region | 49-139 | Disordered | ||||
Sequence: NSSDLGLPNGMDPSQLHTSLGGGGMSGPLGVSGQDTAAKHKHLSELLRPGAPPSASTATGSPGNAASLGMMGGLSGGPVTQGMGGPQQQPS | ||||||
Compositional bias | 55-69 | Polar residues | ||||
Sequence: LPNGMDPSQLHTSLG | ||||||
Domain | 301-387 | TAZ-type | ||||
Sequence: DPEKRKLIQQQLVLLLHAHKCHRREQANGEVRQCNLPHCRTMKNVLNHMTHCQAGKSCQVAHCASSRQIISHWKNCTRHDCPVCLPL | ||||||
Zinc finger | 301-387 | TAZ-type | ||||
Sequence: DPEKRKLIQQQLVLLLHAHKCHRREQANGEVRQCNLPHCRTMKNVLNHMTHCQAGKSCQVAHCASSRQIISHWKNCTRHDCPVCLPL | ||||||
Region | 395-433 | Disordered | ||||
Sequence: NQQSLLGGAGMAMGGPLGGSLPGGQPSAPNINPPSQIDP | ||||||
Region | 453-476 | Disordered | ||||
Sequence: SNQNQQTSVPGQPGMRSLNNMAGG | ||||||
Domain | 533-612 | KIX | ||||
Sequence: GMRKSWHEDITQDLRNHLVHKLVQAIFPTPDPAALKDRRMENLVAYARKVEGDMYESANSRAEYYHLLAEKIYKIQKELE | ||||||
Region | 615-634 | Disordered | ||||
Sequence: RRTRLQKQDGPHSDPSLVQA | ||||||
Region | 718-1020 | Disordered | ||||
Sequence: LGQGAVGLNQPAGQGAMPQNQMPTPPSLSVHSPVAQSQSSVPVSGAAAGPQGPPSNHPPPAPQPGLHTHCPPLRQNSPSPARSLTPTPAPHQTPPQLPGNQTPQPHTPNSSTTMAPPASQLPPMAQGVASEKSSQLQQQSHGGGATGGPQTGLASSVPSQNAHGLCTHPHSPLSQKSSATVDGQASTPASVSSADPSSQLTSSEPTAPLDSKTEVKQQDEEEENENETEDKASGKMAAMQTEIKSEEKPEIKKEEPAGDECKTEPMETSTAEDKKPEVKTEPKEEEVAGANSTPANTQSKKKE | ||||||
Compositional bias | 730-762 | Polar residues | ||||
Sequence: GQGAMPQNQMPTPPSLSVHSPVAQSQSSVPVSG | ||||||
Compositional bias | 769-784 | Pro residues | ||||
Sequence: GPPSNHPPPAPQPGLH | ||||||
Compositional bias | 800-819 | Pro residues | ||||
Sequence: SLTPTPAPHQTPPQLPGNQT | ||||||
Compositional bias | 820-836 | Polar residues | ||||
Sequence: PQPHTPNSSTTMAPPAS | ||||||
Compositional bias | 843-929 | Polar residues | ||||
Sequence: QGVASEKSSQLQQQSHGGGATGGPQTGLASSVPSQNAHGLCTHPHSPLSQKSSATVDGQASTPASVSSADPSSQLTSSEPTAPLDSK | ||||||
Compositional bias | 958-1003 | Basic and acidic residues | ||||
Sequence: TEIKSEEKPEIKKEEPAGDECKTEPMETSTAEDKKPEVKTEPKEEE | ||||||
Domain | 1039-1122 | Bromo | ||||
Sequence: RQDPESLPFRQPVDPQLLGIPVRIRTSNKTNLDYFDIVKNPIDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVY | ||||||
Domain | 1280-1657 | CBP/p300-type HAT | ||||
Sequence: KYAAKRLPQTKLGNFLETRVNDYLKRQNHPESGEVTIRVVHISDKVVEVKPGMKSRFVDSGEMSESFPYRTKALFAFEEIDGTDVCFFGMHVQEYGSDCPPPNQRRVYISYLDSVHFFQPRHLRTGVYHEILIGYLEYVKKMGFVMGHIWACPPSEGDDYIFHCHPSDQKIPKPKRLQEWYKKMLDKAVTERIVHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKREENNTSSESIDATNGDSKNAKKKNNKKTSKNKSSLSRANKKKPGMPNVSNDLSQKLYATMEKHKEVFFVIRFIAGPAANSLPPISDPDTLMACDLMDGRDAFLTLARDKHLEFSSLRRAKWSSMCMLVELHNQTQ | ||||||
Compositional bias | 1513-1528 | Basic and acidic residues | ||||
Sequence: LEQEEEERKREENNTS | ||||||
Region | 1513-1572 | Disordered | ||||
Sequence: LEQEEEERKREENNTSSESIDATNGDSKNAKKKNNKKTSKNKSSLSRANKKKPGMPNVSN | ||||||
Compositional bias | 1545-1559 | Basic residues | ||||
Sequence: KNNKKTSKNKSSLSR | ||||||
Domain | 1659-1707 | ZZ-type | ||||
Sequence: RFVYTCNECKHHVETRFHCTVCEDYDLCITCYNVKGHEHKMEKLGLGLD | ||||||
Domain | 1722-1803 | TAZ-type | ||||
Sequence: GDSRRLSIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPICKQLIALCCYHAKHCQETKCPVPFCLNI | ||||||
Zinc finger | 1722-1803 | TAZ-type | ||||
Sequence: GDSRRLSIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPICKQLIALCCYHAKHCQETKCPVPFCLNI | ||||||
Region | 1826-1988 | Disordered | ||||
Sequence: MATMQRVGQPPPCGGGPPGGLPSPGNNGATGPSTPTSVGTQPATPQTPTQLTPNLISLPQPGAGGVPAGAPQQSPQHPVHHQFQQMPGAGGMMNSQQQQMVPQQSLGQVPHPHNQYGPHPTGPSPNTQSQGKPGLGPATPPQLPSNPGTVPMAQQQQPTGPPA | ||||||
Compositional bias | 1851-1882 | Polar residues | ||||
Sequence: NNGATGPSTPTSVGTQPATPQTPTQLTPNLIS | ||||||
Compositional bias | 1913-1936 | Polar residues | ||||
Sequence: GAGGMMNSQQQQMVPQQSLGQVPH | ||||||
Compositional bias | 1945-1960 | Polar residues | ||||
Sequence: PTGPSPNTQSQGKPGL | ||||||
Region | 2083-2157 | Disordered | ||||
Sequence: QQVAVQGQMPPQMHPQQPRMNPPLQPQQQQWPGQGMPTQQRPAMMSQQGMVSMQPQPQPQQPSQQTQQQQAPQMP | ||||||
Compositional bias | 2105-2157 | Polar residues | ||||
Sequence: PLQPQQQQWPGQGMPTQQRPAMMSQQGMVSMQPQPQPQQPSQQTQQQQAPQMP | ||||||
Region | 2228-2266 | Disordered | ||||
Sequence: KYKGGTGGPSGPQGGPGPMGGQPVGVNTGVPQPGMHLGQ | ||||||
Compositional bias | 2328-2346 | Polar residues | ||||
Sequence: HQQQQQQQQGIQGQGTPNM | ||||||
Region | 2328-2348 | Disordered | ||||
Sequence: HQQQQQQQQGIQGQGTPNMAN | ||||||
Compositional bias | 2371-2454 | Polar residues | ||||
Sequence: QQQQQQQQMSNHAAFQQQQGYMSQQGNMQVPPGGQPLQGVQPGQQQNFPGNPAQQQAAAALQQRLAQQQHQLQMQQQQNAATQG | ||||||
Region | 2371-2472 | Disordered | ||||
Sequence: QQQQQQQQMSNHAAFQQQQGYMSQQGNMQVPPGGQPLQGVQPGQQQNFPGNPAQQQAAAALQQRLAQQQHQLQMQQQQNAATQGPDMGPGGGPQPTQLGPGL | ||||||
Compositional bias | 2493-2537 | Polar residues | ||||
Sequence: HLSGTSPAQQNNPMSPQQQQISQSPHLQGQQLPSSLSNQVCSPQP | ||||||
Region | 2493-2645 | Disordered | ||||
Sequence: HLSGTSPAQQNNPMSPQQQQISQSPHLQGQQLPSSLSNQVCSPQPSPRPQSQPPHSSPSPRLQPQPSPHHISPQTQTGSPHPSHLQQHHSGMAPPPPPHQQPQHNSKDPSGFGADQNAMLSQLSGMAGLHGPGANDMLPPSGQDLGINMNLTL | ||||||
Compositional bias | 2538-2559 | Pro residues | ||||
Sequence: SPRPQSQPPHSSPSPRLQPQPS | ||||||
Compositional bias | 2560-2578 | Polar residues | ||||
Sequence: PHHISPQTQTGSPHPSHLQ | ||||||
Compositional bias | 2596-2615 | Polar residues | ||||
Sequence: HNSKDPSGFGADQNAMLSQL |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,645
- Mass (Da)287,470
- Last updated2022-08-03 v1
- ChecksumCD00CC10BCC020A8
Computationally mapped potential isoform sequences
There are 7 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8M3AQU5 | A0A8M3AQU5_DANRE | ep300b | 2646 | ||
A0A8M3AQI0 | A0A8M3AQI0_DANRE | ep300b | 2639 | ||
A0A8M3B0W3 | A0A8M3B0W3_DANRE | ep300b | 2645 | ||
A0A8M3B0X0 | A0A8M3B0X0_DANRE | ep300b | 2625 | ||
A0A8M3AQU7 | A0A8M3AQU7_DANRE | ep300b | 2635 | ||
A0A8M3AXZ0 | A0A8M3AXZ0_DANRE | ep300b | 2617 | ||
A0A8M3B890 | A0A8M3B890_DANRE | ep300b | 2636 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 55-69 | Polar residues | ||||
Sequence: LPNGMDPSQLHTSLG | ||||||
Compositional bias | 730-762 | Polar residues | ||||
Sequence: GQGAMPQNQMPTPPSLSVHSPVAQSQSSVPVSG | ||||||
Compositional bias | 769-784 | Pro residues | ||||
Sequence: GPPSNHPPPAPQPGLH | ||||||
Compositional bias | 800-819 | Pro residues | ||||
Sequence: SLTPTPAPHQTPPQLPGNQT | ||||||
Compositional bias | 820-836 | Polar residues | ||||
Sequence: PQPHTPNSSTTMAPPAS | ||||||
Compositional bias | 843-929 | Polar residues | ||||
Sequence: QGVASEKSSQLQQQSHGGGATGGPQTGLASSVPSQNAHGLCTHPHSPLSQKSSATVDGQASTPASVSSADPSSQLTSSEPTAPLDSK | ||||||
Compositional bias | 958-1003 | Basic and acidic residues | ||||
Sequence: TEIKSEEKPEIKKEEPAGDECKTEPMETSTAEDKKPEVKTEPKEEE | ||||||
Compositional bias | 1513-1528 | Basic and acidic residues | ||||
Sequence: LEQEEEERKREENNTS | ||||||
Compositional bias | 1545-1559 | Basic residues | ||||
Sequence: KNNKKTSKNKSSLSR | ||||||
Compositional bias | 1851-1882 | Polar residues | ||||
Sequence: NNGATGPSTPTSVGTQPATPQTPTQLTPNLIS | ||||||
Compositional bias | 1913-1936 | Polar residues | ||||
Sequence: GAGGMMNSQQQQMVPQQSLGQVPH | ||||||
Compositional bias | 1945-1960 | Polar residues | ||||
Sequence: PTGPSPNTQSQGKPGL | ||||||
Compositional bias | 2105-2157 | Polar residues | ||||
Sequence: PLQPQQQQWPGQGMPTQQRPAMMSQQGMVSMQPQPQPQQPSQQTQQQQAPQMP | ||||||
Compositional bias | 2328-2346 | Polar residues | ||||
Sequence: HQQQQQQQQGIQGQGTPNM | ||||||
Compositional bias | 2371-2454 | Polar residues | ||||
Sequence: QQQQQQQQMSNHAAFQQQQGYMSQQGNMQVPPGGQPLQGVQPGQQQNFPGNPAQQQAAAALQQRLAQQQHQLQMQQQQNAATQG | ||||||
Compositional bias | 2493-2537 | Polar residues | ||||
Sequence: HLSGTSPAQQNNPMSPQQQQISQSPHLQGQQLPSSLSNQVCSPQP | ||||||
Compositional bias | 2538-2559 | Pro residues | ||||
Sequence: SPRPQSQPPHSSPSPRLQPQPS | ||||||
Compositional bias | 2560-2578 | Polar residues | ||||
Sequence: PHHISPQTQTGSPHPSHLQ | ||||||
Compositional bias | 2596-2615 | Polar residues | ||||
Sequence: HNSKDPSGFGADQNAMLSQL |
Keywords
- Technical term