A0A8M3AVL1 · A0A8M3AVL1_DANRE
- ProteinTyrosine-protein kinase receptor
- Genentrk2a
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids791 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
Catalytic activity
- L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
Features
Showing features for site, binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Site | 483 | Interaction with SHC1 | |||
Binding site | 511-519 | ATP (UniProtKB | ChEBI) | |||
Binding site | 539 | ATP (UniProtKB | ChEBI) | |||
Active site | 645 | Proton acceptor | |||
Site | 786 | Interaction with PLCG1 | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | axon | |
Cellular Component | plasma membrane | |
Cellular Component | receptor complex | |
Cellular Component | synapse | |
Molecular Function | ATP binding | |
Molecular Function | brain-derived neurotrophic factor binding | |
Molecular Function | brain-derived neurotrophic factor receptor activity | |
Biological Process | cell differentiation | |
Biological Process | cellular response to brain-derived neurotrophic factor stimulus | |
Biological Process | nervous system development | |
Biological Process | positive regulation of neuron projection development | |
Biological Process | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | |
Biological Process | protein phosphorylation | |
Biological Process | trans-synaptic signaling by neuropeptide, modulating synaptic transmission |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTyrosine-protein kinase receptor
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionA0A8M3AVL1
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 398-421 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-25 | ||||
Chain | PRO_5035468194 | 26-791 | Tyrosine-protein kinase receptor | ||
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 186-273 | Ig-like | |||
Region | 441-460 | Disordered | |||
Domain | 505-776 | Protein kinase | |||
Sequence similarities
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length791
- Mass (Da)89,132
- Last updated2022-08-03 v1
- Checksum99A7A18173FE0481
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8M3B2B0 | A0A8M3B2B0_DANRE | ntrk2a | 447 | ||
A0A8M3B589 | A0A8M3B589_DANRE | ntrk2a | 787 |
Keywords
- Technical term