A0A8M3AVL1 · A0A8M3AVL1_DANRE

Function

Catalytic activity

Features

Showing features for site, binding site, active site.

1791100200300400500600700
Type
IDPosition(s)Description
Site483Interaction with SHC1
Binding site511-519ATP (UniProtKB | ChEBI)
Binding site539ATP (UniProtKB | ChEBI)
Active site645Proton acceptor
Site786Interaction with PLCG1

GO annotations

AspectTerm
Cellular Componentaxon
Cellular Componentplasma membrane
Cellular Componentreceptor complex
Cellular Componentsynapse
Molecular FunctionATP binding
Molecular Functionbrain-derived neurotrophic factor binding
Molecular Functionbrain-derived neurotrophic factor receptor activity
Biological Processcell differentiation
Biological Processcellular response to brain-derived neurotrophic factor stimulus
Biological Processnervous system development
Biological Processpositive regulation of neuron projection development
Biological Processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Biological Processprotein phosphorylation
Biological Processtrans-synaptic signaling by neuropeptide, modulating synaptic transmission

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Tyrosine-protein kinase receptor
  • EC number

Gene names

    • Name
      ntrk2a

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    A0A8M3AVL1

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Single-pass type I membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane398-421Helical

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-25
ChainPRO_503546819426-791Tyrosine-protein kinase receptor

Keywords

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain186-273Ig-like
Region441-460Disordered
Domain505-776Protein kinase

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    791
  • Mass (Da)
    89,132
  • Last updated
    2022-08-03 v1
  • Checksum
    99A7A18173FE0481
MSFGMTGCGFGWAVMLLALWRPATACPELCTCTGLRISCVDAERSIMAFPKLESEADMENVTDIYIANQISFTSINERDLEFYRSLRNLTVINTKLAYIARLAFQSNPKLQYLNLKENNLSKLSWRTFRHLNISYLLLAGNPLQCLCDNMWLKQWRVEEAEELLCVEEGGKRRALATLTLPDCVLPTVTLTPTNVTMKKGLNVTLTCNTSGMPTPNLTWTTCKLNSAFKEEGSGQISRSQLKLTNVSSLDNKCRITCRSDNMVGESEASVELDILFPPVISKLTDAIPDHHWCIPFSVSGNPKPKLRWLLDEQPIQEGKFIHTMIHDYSEGEYHGCLQLDSPTHINNGMYTLLARNQFGEDSKAVSAHFMHEPWNVSEPLYYDATTDDTPLGPPEDKVAVYVVVGIAAITFTGFVLMLVILKFGRNSKFGIKGPSSVISNDDDSASPLHHVSNGSNTPSSSDMNADAVIIGMTKIPVIENPQYFRSTSSLLKSDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLSADQEKILVAVKTLKEASENARKDFHREAELLTNLQHEHIVTFYGVCVESDPLIMVFEYMMHGDLNKFLRAHGPDAVLMSDGQIQQQAELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPKEVYDLMLGCWQREPHTRLNIKEIHNLLLNLAKASPVYLDILG

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8M3B2B0A0A8M3B2B0_DANREntrk2a447
A0A8M3B589A0A8M3B589_DANREntrk2a787

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help