A0A8M3AT35 · A0A8M3AT35_DANRE
- Proteinadenylate cyclase
- Geneadcy3a
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1118 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
Catalytic activity
- ATP = 3',5'-cyclic AMP + diphosphate
Cofactor
Protein has several cofactor binding sites:
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )
Note: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 324 | Mg2+ 2 (UniProtKB | ChEBI); catalytic | ||||
Sequence: D | ||||||
Binding site | 324 | Mg2+ 1 (UniProtKB | ChEBI); catalytic | ||||
Sequence: D | ||||||
Binding site | 324-329 | ATP (UniProtKB | ChEBI) | ||||
Sequence: DIVGFT | ||||||
Binding site | 325 | Mg2+ 2 (UniProtKB | ChEBI); catalytic | ||||
Sequence: I | ||||||
Binding site | 366-368 | ATP (UniProtKB | ChEBI) | ||||
Sequence: LGD | ||||||
Binding site | 368 | Mg2+ 2 (UniProtKB | ChEBI); catalytic | ||||
Sequence: D | ||||||
Binding site | 368 | Mg2+ 1 (UniProtKB | ChEBI); catalytic | ||||
Sequence: D | ||||||
Binding site | 412 | ATP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 949 | ATP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 1036-1038 | ATP (UniProtKB | ChEBI) | ||||
Sequence: DIW | ||||||
Binding site | 1043-1047 | ATP (UniProtKB | ChEBI) | ||||
Sequence: NVASR | ||||||
Binding site | 1083 | ATP (UniProtKB | ChEBI) | ||||
Sequence: K |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | adenylate cyclase activity | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Biological Process | cAMP biosynthetic process | |
Biological Process | intracellular signal transduction | |
Biological Process | melanosome localization |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameadenylate cyclase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionA0A8M3AT35
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 78-100 | Helical | ||||
Sequence: LLVLVVFAALFDCYIIVMCTVLY | ||||||
Transmembrane | 106-125 | Helical | ||||
Sequence: ASVAVASVGLAADVLLYLLC | ||||||
Transmembrane | 137-157 | Helical | ||||
Sequence: RLVPYALWVLIAAQIFCYLGL | ||||||
Transmembrane | 169-185 | Helical | ||||
Sequence: VGWQAFFSFSFFLTLPL | ||||||
Transmembrane | 190-210 | Helical | ||||
Sequence: IVLITSVSCGVHTLVLGVTIA | ||||||
Transmembrane | 230-247 | Helical | ||||
Sequence: MVIYVCAITVGVMSYYMA | ||||||
Transmembrane | 625-645 | Helical | ||||
Sequence: GAAFSCSCVVLLFTAVMEALI | ||||||
Transmembrane | 651-675 | Helical | ||||
Sequence: ANYVTLAVGEVLLLILTICSLAAIF | ||||||
Transmembrane | 695-714 | Helical | ||||
Sequence: WARNTWAMAAIFIVTLADIV | ||||||
Transmembrane | 748-766 | Helical | ||||
Sequence: YYSFIAVLALIATTMLVQV | ||||||
Transmembrane | 773-791 | Helical | ||||
Sequence: TLMLLITVATGAVNIYSWS | ||||||
Transmembrane | 811-830 | Helical | ||||
Sequence: PSKYTMSVMIFIMMVSFYYF |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 319-446 | Guanylate cyclase | ||||
Sequence: SILFADIVGFTQLSSSCSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAACSIMMGLAMVEAISYVREKTQTDVDMRVGVHSGTVLGGVLGQKRWQYDVWSTDVTVANKME | ||||||
Coiled coil | 561-591 | |||||
Sequence: LRDLAERVIDAQENEQELNKLLNEALLERET | ||||||
Domain | 897-1049 | Guanylate cyclase | ||||
Sequence: GVMFASIPNFSDFYTEESINNGGIECLRFLNEIISDFDSLLDEPQFRCITKIKTIGSTYMAASGVTSDNNTNGYACMKKEEISDRERWQHLADLADFALAMKVTLMNINYQSFNNFMLRIGLNKGAVLAGVIGARKPHFDIWGNTVNVASRME |
Sequence similarities
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,118
- Mass (Da)126,216
- Last updated2022-08-03 v1
- Checksum0361558340848392
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
E7FDV3 | E7FDV3_DANRE | adcy3a | 1119 | ||
A0A8M1NT79 | A0A8M1NT79_DANRE | adcy3a | 1071 |
Keywords
- Technical term