A0A8M3AT35 · A0A8M3AT35_DANRE

Function

function

Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site324Mg2+ 2 (UniProtKB | ChEBI); catalytic
Binding site324Mg2+ 1 (UniProtKB | ChEBI); catalytic
Binding site324-329ATP (UniProtKB | ChEBI)
Binding site325Mg2+ 2 (UniProtKB | ChEBI); catalytic
Binding site366-368ATP (UniProtKB | ChEBI)
Binding site368Mg2+ 2 (UniProtKB | ChEBI); catalytic
Binding site368Mg2+ 1 (UniProtKB | ChEBI); catalytic
Binding site412ATP (UniProtKB | ChEBI)
Binding site949ATP (UniProtKB | ChEBI)
Binding site1036-1038ATP (UniProtKB | ChEBI)
Binding site1043-1047ATP (UniProtKB | ChEBI)
Binding site1083ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionadenylate cyclase activity
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Biological ProcesscAMP biosynthetic process
Biological Processintracellular signal transduction
Biological Processmelanosome localization

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    adenylate cyclase
  • EC number

Gene names

    • Name
      adcy3a
    • Synonyms
      adcy3
      , adcy3l

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    A0A8M3AT35

Proteomes

Organism-specific databases

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane78-100Helical
Transmembrane106-125Helical
Transmembrane137-157Helical
Transmembrane169-185Helical
Transmembrane190-210Helical
Transmembrane230-247Helical
Transmembrane625-645Helical
Transmembrane651-675Helical
Transmembrane695-714Helical
Transmembrane748-766Helical
Transmembrane773-791Helical
Transmembrane811-830Helical

Keywords

  • Cellular component

Family & Domains

Features

Showing features for domain, coiled coil.

TypeIDPosition(s)Description
Domain319-446Guanylate cyclase
Coiled coil561-591
Domain897-1049Guanylate cyclase

Sequence similarities

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,118
  • Mass (Da)
    126,216
  • Last updated
    2022-08-03 v1
  • Checksum
    0361558340848392
MPRNRAFSEPEYSAEYSADCSVTLPSDPGQAVGRTHEVTVRSSGCCLCLPRFMRLTFAPDSLENLYQTYFRRQRHETLLVLVVFAALFDCYIIVMCTVLYTADKLASVAVASVGLAADVLLYLLCRYGLLPDRVTRRLVPYALWVLIAAQIFCYLGLNFARFHQPSDTVGWQAFFSFSFFLTLPLRLTPIVLITSVSCGVHTLVLGVTIAQQQQEDIQGAALGRQLLANMVIYVCAITVGVMSYYMADRKHRKAFLEARQSLEVKLNLEEQSQQQERLLLSILPKHIADEMLQDMKKEASQKEMQQFNTMYMYRHENVSILFADIVGFTQLSSSCSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAACSIMMGLAMVEAISYVREKTQTDVDMRVGVHSGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQNTLECLHGEFDVEPGNGGDRCEYLKERGIETYLVVLPKGPVGKNGINGVLSVTSSNGNSPLLINTTECNGSVHTACTTPEDPEELDTRVVNPSFPNPRRRLRLRDLAERVIDAQENEQELNKLLNEALLERETVQALKGKYTNRLSLRFTDPELETRFSVEKEKQSGAAFSCSCVVLLFTAVMEALIDPWLVANYVTLAVGEVLLLILTICSLAAIFPRVFPKRLVSFSTWIDHTRWARNTWAMAAIFIVTLADIVDMLSCRAPQTSTVESTAVPPVVTAIRGCAENPKYYSFIAVLALIATTMLVQVSHMVKLTLMLLITVATGAVNIYSWSQTFDLYDLTRFKEYRVNLVPSKYTMSVMIFIMMVSFYYFSRHVEKLARTLFLWKIEVHEQKEKVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQSYDEIGVMFASIPNFSDFYTEESINNGGIECLRFLNEIISDFDSLLDEPQFRCITKIKTIGSTYMAASGVTSDNNTNGYACMKKEEISDRERWQHLADLADFALAMKVTLMNINYQSFNNFMLRIGLNKGAVLAGVIGARKPHFDIWGNTVNVASRMESTGVMGNIQVVEDCYCILKDYGFRFVRRGPIFVKGKGELLTYFLKGREKQGSFINGSFVTLPHQVVDSS

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
E7FDV3E7FDV3_DANREadcy3a1119
A0A8M1NT79A0A8M1NT79_DANREadcy3a1071

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

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