A0A8M3AR84 · A0A8M3AR84_DANRE
- ProteinProtein kinase C
- Geneprkcab
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids681 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+
Cofactor
Note: Binds 3 Ca2+ ions per subunit. The ions are bound to the C2 domain.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 184 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: M | ||||||
Binding site | 185 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 191 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 193 | a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 243 | a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) (UniProtKB | ChEBI) | ||||
Sequence: W | ||||||
Binding site | 244 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 245 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: W | ||||||
Binding site | 246 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 250 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 252 | Ca2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 353-361 | ATP (UniProtKB | ChEBI) | ||||
Sequence: LGKGSFGKV | ||||||
Binding site | 376 | ATP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Active site | 471 | Proton acceptor | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | diacylglycerol-dependent serine/threonine kinase activity | |
Molecular Function | protein serine/threonine kinase activity | |
Molecular Function | zinc ion binding | |
Biological Process | intracellular signal transduction | |
Biological Process | protein phosphorylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProtein kinase C
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionA0A8M3AR84
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 34-84 | Phorbol-ester/DAG-type | ||||
Sequence: NHKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVSFSC | ||||||
Domain | 99-149 | Phorbol-ester/DAG-type | ||||
Sequence: KHKFKIHSYGSPTFCDHCGSLLYGLIHQGMKCDTCDMNVHKQCVMNVPSLC | ||||||
Domain | 156-273 | C2 | ||||
Sequence: RRGRIFMKIEVSGDRLHVTVGEARNLIPMDPNGLSDPYVKLKLIPDPKNETKQKTRTIRSSLNPTWNESFIFKLKASDKERRLSVEVWDWDRTTRNDFMGSMSFGVSELIKAPVSGWY | ||||||
Domain | 347-605 | Protein kinase | ||||
Sequence: FHFLALLGKGSFGKVMLAEMKSTEELYAIKILKKDVVIQDDDVECTMVEKRVLAQREKPPFLTQLHSCFQTVDRLYFVMEYINGGDLMYHIQQVGKFKEPQAVFYAAEIAVGLFFLHRKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENMYEGMTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLTKEAVSICKGLMTKHPSKRLGCGAEGERDIKEQAFF | ||||||
Domain | 606-676 | AGC-kinase C-terminal | ||||
Sequence: RRIDWDRLANREIQPPFKPKVCGKAAENFDKFFTRTQPMLTPPDQLVIANIDQSEFAGFSFINPEFIHPAS |
Sequence similarities
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length681
- Mass (Da)78,049
- Last updated2022-08-03 v1
- Checksum55467CDB5DBAD066
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8M3B1B9 | A0A8M3B1B9_DANRE | prkcab | 671 |
Keywords
- Technical term