A0A8M2BKA6 · A0A8M2BKA6_DANRE
- ProteinNAD-dependent protein deacetylase sirtuin-1 isoform X2
- Genesirt1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids695 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
Cofactor
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 299 | Proton acceptor | |||
Binding site | 307 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 310 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 331 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 334 | Zn2+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nuclear inner membrane | |
Cellular Component | nucleoplasm | |
Cellular Component | nucleus | |
Cellular Component | rDNA heterochromatin | |
Molecular Function | metal ion binding | |
Molecular Function | NAD+ binding | |
Molecular Function | NAD-dependent histone deacetylase activity | |
Molecular Function | p53 binding | |
Molecular Function | transcription corepressor activity | |
Molecular Function | transferase activity | |
Biological Process | cell migration involved in sprouting angiogenesis | |
Biological Process | fin regeneration | |
Biological Process | negative regulation of DNA-templated transcription | |
Biological Process | positive regulation of angiogenesis | |
Biological Process | regulation of gliogenesis | |
Biological Process | vasculature development |
Keywords
- Molecular function
- Ligand
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionA0A8M2BKA6
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 1-28 | Basic and acidic residues | |||
Region | 1-119 | Disordered | |||
Compositional bias | 52-69 | Polar residues | |||
Domain | 172-432 | Deacetylase sirtuin-type | |||
Compositional bias | 473-505 | Basic and acidic residues | |||
Region | 473-511 | Disordered | |||
Region | 528-577 | Disordered | |||
Compositional bias | 560-577 | Basic and acidic residues | |||
Compositional bias | 638-652 | Polar residues | |||
Region | 638-695 | Disordered | |||
Compositional bias | 653-689 | Basic and acidic residues | |||
Family and domain databases
Sequence
- Sequence statusComplete
- Length695
- Mass (Da)77,862
- Last updated2022-08-03 v1
- MD5 Checksum1BD690F2A96313B0FDA60D30A0EE11D4
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
E7F8W3 | E7F8W3_DANRE | sirt1 | 710 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 1-28 | Basic and acidic residues | |||
Compositional bias | 52-69 | Polar residues | |||
Compositional bias | 473-505 | Basic and acidic residues | |||
Compositional bias | 560-577 | Basic and acidic residues | |||
Compositional bias | 638-652 | Polar residues | |||
Compositional bias | 653-689 | Basic and acidic residues | |||
Keywords
- Technical term