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A0A8M2BKA6 · A0A8M2BKA6_DANRE

Function

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Features

Showing features for active site, binding site.

169550100150200250300350400450500550600650
Type
IDPosition(s)Description
Active site299Proton acceptor
Binding site307Zn2+ (UniProtKB | ChEBI)
Binding site310Zn2+ (UniProtKB | ChEBI)
Binding site331Zn2+ (UniProtKB | ChEBI)
Binding site334Zn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentnuclear inner membrane
Cellular Componentnucleoplasm
Cellular Componentnucleus
Cellular ComponentrDNA heterochromatin
Molecular Functionmetal ion binding
Molecular FunctionNAD+ binding
Molecular FunctionNAD-dependent histone deacetylase activity
Molecular Functionp53 binding
Molecular Functiontranscription corepressor activity
Molecular Functiontransferase activity
Biological Processcell migration involved in sprouting angiogenesis
Biological Processfin regeneration
Biological Processnegative regulation of DNA-templated transcription
Biological Processpositive regulation of angiogenesis
Biological Processregulation of gliogenesis
Biological Processvasculature development

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • NAD-dependent protein deacetylase sirtuin-1 isoform X2

Gene names

    • Name
      sirt1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    A0A8M2BKA6

Proteomes

Organism-specific databases

Structure

3D structure databases

Family & Domains

Features

Showing features for compositional bias, region, domain.

Type
IDPosition(s)Description
Compositional bias1-28Basic and acidic residues
Region1-119Disordered
Compositional bias52-69Polar residues
Domain172-432Deacetylase sirtuin-type
Compositional bias473-505Basic and acidic residues
Region473-511Disordered
Region528-577Disordered
Compositional bias560-577Basic and acidic residues
Compositional bias638-652Polar residues
Region638-695Disordered
Compositional bias653-689Basic and acidic residues

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    695
  • Mass (Da)
    77,862
  • Last updated
    2022-08-03 v1
  • MD5 Checksum
    1BD690F2A96313B0FDA60D30A0EE11D4
MADGENKRAESAEPDEPLPKKPRLLELSGDSEHSATAGADTLDEKPARMDESQQALSINNNNNTRPTEPGQPADPEPEISELTDEGVHPNGFTSPDLLRDDDDCSSRASSSDWTPQPQIGSYRFIQQHIMRGTDPRAILKDLLPETVLPPDLDDMTLWQIIINISEPPKRKKRKDINTLEDVVRLLNERKKILVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIDYFRRDPRPFFKFAKEIYPGQFQPSPCHRFISMLDKKGRLLRNYTQNIDTLEQVAGIQKIIQCHGSFATASCLICKHKVDCEAIREDIFNQVVPHCPRCPSDVPYAIMKPDIVFFGENLPEFFHRAMKQDKDEVDLLIVIGSSLKVRPVALIPSSIPHDVPQVLINREPLPHLNFDVELLGDCDVIVNELCHRLNGDFQQLCYNSSRLSEITEKPAAPEHTENTSADHSHADAEHIENTSADRDDAKHTENTPTDHADAEHTKNTSADHANAEHTENTSAGHVNAEHIEHMSKDHANPKDDQSSLSVNEEELASPAAETHALDSTEISAHTERSKEADAVNTDDAACVKDEENTDRLRVEMRRRCWRSRICQSPISKRLGASQYLFQAPNRYVFHGAEVYSSSEDESSSSCGSESDGSFQHEDSEVEENGAAMTDKETDTETVQDSEHRRLQTHCTQHTQ

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
E7F8W3E7F8W3_DANREsirt1710

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-28Basic and acidic residues
Compositional bias52-69Polar residues
Compositional bias473-505Basic and acidic residues
Compositional bias560-577Basic and acidic residues
Compositional bias638-652Polar residues
Compositional bias653-689Basic and acidic residues

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

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