A0A8M2BG42 · A0A8M2BG42_DANRE

Function

Catalytic activity

Cofactor

Fe2+ (UniProtKB | Rhea| CHEBI:29033 )

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentMLL3/4 complex
Molecular Functionchromatin DNA binding
Molecular Functionhistone H3K27me2/H3K27me3 demethylase activity
Molecular Functionmetal ion binding
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Biological Processanterior/posterior pattern specification
Biological Processbrain development
Biological Processgerm cell migration
Biological Processheart development
Biological Processregulation of gene expression

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    [histone H3]-trimethyl-L-lysine(27) demethylase
  • EC number

Gene names

    • Name
      kdm6al
    • Synonyms
      utxl1
      , zgc:158313

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    A0A8M2BG42

Proteomes

Organism-specific databases

Subcellular Location

Keywords

  • Cellular component

PTM/Processing

Keywords

Family & Domains

Features

Showing features for region, compositional bias, repeat, domain.

Type
IDPosition(s)Description
Region14-45Disordered
Compositional bias17-42Basic and acidic residues
Repeat130-163TPR
Repeat318-351TPR
Compositional bias434-462Polar residues
Region434-504Disordered
Compositional bias470-503Polar residues
Compositional bias545-573Polar residues
Region545-838Disordered
Compositional bias651-668Polar residues
Compositional bias701-731Polar residues
Compositional bias738-753Polar residues
Compositional bias771-789Polar residues
Domain1049-1212JmjC

Sequence similarities

Belongs to the UTX family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,356
  • Mass (Da)
    148,630
  • Last updated
    2022-08-03 v1
  • Checksum
    FE4613E5B4EC675C
MKPCRVSVAAAAARRLSAAGDEEKKMAAGKASEPEEESPRLSAQESDTLARVDSSLFGYQRLHEDGASMKALLVKAVRCYESLILKAEGKVDPEFFCQLGHFNLLLEEYPKALSAYQRYYSLQSDYWKNAAFLYGLGMVYFHYNAFQWAIKAFQEVLYIDPGFSRAKEIHLRLGLMFKVNTDYESSLKHFQLALIDSSRCTLSKAEIQFHIAHLYEIQKRHRAAKEAYESLLQTEDLQTPVRAAALQQLGWMHHTVEQLGDKANKDSYAIQCLQKSLEADPNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHSHAAAWMDLGTLYESCNQPHDAIKCYINATRSKTCSNTAALAARIKYLQAQFCKLRLNSLQGKSKTLPNIEEAWSLPIPAELTSRQGVQSTGPQACKAQPGASSGSQASAPALPPHSTALEPAGAQTSPARRRRSSSPAQSSTDSWSSGSAHTPVPHWYLTPQKLQLLEQLRASRASLKPAQLQMLEQMEAQLSAMHLHQQQMRQNSSGQIRPSLSNGPSLPASRGPALQTLHNGPGPRPGPQTPAVRNNHTESRANGDVPYLHPNTLPHNCTSPGAGRRSPQLPPAQGLQKGPGSHWAGPNGIRSDSSSGSADGGPHNQVVDSASAGDAAGSSGSPPPRRCSPCALPHTATSGAPHSTIPTKESAALQANGSTATDTHSPASPHRPPSPVSATTTDNPPLPNLQTLPATAPAAPLTPVGSTLPAPGSSSASSPASALSAASPSPRPGDPTTPLRPLQAPVTVNGCSEDSRSPLKLEPEQSITSSAAHRSASISIYPTSTDALKACRSLGRNGLSSCSLLLNRCPPPRLPPPPAPPLDKDKLNPPTPSIYLENKRDAFFPPLHQFCTNPSNPVTVIRGLAGALKLDLGLFSTKTLVDMNPEHLVEVRTQLSQPADENWDASGTRKQWRCESTRSHTTIAKYAQYQAASFQESLREENEKKGQKELSDSEIASSESVCRRRKGPFKQVKFGMNIDVSDEKKWKLQLQELSKLPAFARVVSAGNLLSHVGHRILGMNTVQLCMKVPGSRTPGHQEHNNFCAVNINIGPGDCEWFAVPEPYWGVMSEFCERNNINFLKGSWWPNLEDLYEARVPVYRFIQRPGDLVWLNTGTVHWGQAIGWCNNISWNVGPLTAHQYKLAVERYEWNKLQSVKSMVPMVHLSWNMARNIKVADQRLFEMIKFCLLRTLRQTQSIRESLLSAGKETLWQRRSRDEPAHYCSVCEVEVWNLLFVCSEGSPCRPAAAVQCQDCARKASVDLQGFVVLQQFRMEDLTQLYEQFSLAPALHSSSS

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A1L1S9A1L1S9_DANREkdm6al1311

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias17-42Basic and acidic residues
Compositional bias434-462Polar residues
Compositional bias470-503Polar residues
Compositional bias545-573Polar residues
Compositional bias651-668Polar residues
Compositional bias701-731Polar residues
Compositional bias738-753Polar residues
Compositional bias771-789Polar residues

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help