A0A8M2BCD8 · A0A8M2BCD8_DANRE
- ProteinCellular tumor antigen p53
- Genetp53
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids370 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.
Cofactor
Note: Binds 1 zinc ion per subunit.
Features
Showing features for site, binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Molecular Function | DNA-binding transcription factor activity | |
Molecular Function | metal ion binding | |
Molecular Function | transcription cis-regulatory region binding | |
Biological Process | anatomical structure morphogenesis | |
Biological Process | apoptotic process | |
Biological Process | epithelium development | |
Biological Process | protein tetramerization |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameCellular tumor antigen p53
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionA0A8M2BCD8
Proteomes
Organism-specific databases
PTM/Processing
Features
Showing features for cross-link.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Cross-link | 260 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) | ||||
Sequence: K |
Keywords
- PTM
Interaction
Subunit
Binds DNA as a homotetramer.
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 53-70 | Polar residues | ||||
Sequence: EQPQPSTLPPTSTVPETS | ||||||
Region | 53-81 | Disordered | ||||
Sequence: EQPQPSTLPPTSTVPETSDYPGDHGFRLR | ||||||
Domain | 69-257 | p53 DNA-binding | ||||
Sequence: TSDYPGDHGFRLRFPQSGTAKSVTCTYSPDLNKLFCQLAKTCPVQMVVDVAPPQGSVVRATAIYKKSEHVAEVVRRCPHHERTPDGDNLAPAGHLIRVEGNQRANYREDNITLRHSVFVPYEAPQLGAEWTTVLLNYMCNSSCMGGMNRRPILTIITLETQEGQLLGRRSFEVRVCACPGRDRKTEESN | ||||||
Compositional bias | 251-266 | Basic and acidic residues | ||||
Sequence: RKTEESNFKKDQETKT | ||||||
Region | 251-298 | Disordered | ||||
Sequence: RKTEESNFKKDQETKTMAKTTTGTKRKSSSATLRPEGSKKAKGSSSDE | ||||||
Compositional bias | 267-285 | Polar residues | ||||
Sequence: MAKTTTGTKRKSSSATLRP | ||||||
Domain | 290-330 | p53 tetramerisation | ||||
Sequence: KAKGSSSDEEIFTLQVRGRERYEILKKLNDSLELSDVVPAS | ||||||
Region | 326-370 | Disordered | ||||
Sequence: VVPASDAEKYRQKFMTKNKKENRESSEPKQGKKLMVKDEGRSDSD | ||||||
Compositional bias | 329-370 | Basic and acidic residues | ||||
Sequence: ASDAEKYRQKFMTKNKKENRESSEPKQGKKLMVKDEGRSDSD |
Sequence similarities
Belongs to the p53 family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length370
- Mass (Da)41,558
- Last updated2022-08-03 v1
- Checksum6770991D922284D7
Computationally mapped potential isoform sequences
There are 5 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
P79734 | P53_DANRE | tp53 | 373 | ||
G1K2L5 | G1K2L5_DANRE | tp53 | 374 | ||
B0R0M3 | B0R0M3_DANRE | tp53 | 369 | ||
A0A0B4VFS7 | A0A0B4VFS7_DANRE | tp53 | 261 | ||
A0A8M2BCE6 | A0A8M2BCE6_DANRE | tp53 | 257 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 53-70 | Polar residues | ||||
Sequence: EQPQPSTLPPTSTVPETS | ||||||
Compositional bias | 251-266 | Basic and acidic residues | ||||
Sequence: RKTEESNFKKDQETKT | ||||||
Compositional bias | 267-285 | Polar residues | ||||
Sequence: MAKTTTGTKRKSSSATLRP | ||||||
Compositional bias | 329-370 | Basic and acidic residues | ||||
Sequence: ASDAEKYRQKFMTKNKKENRESSEPKQGKKLMVKDEGRSDSD |
Keywords
- Technical term