A0A8M2BBD6 · A0A8M2BBD6_DANRE
- ProteinPotassium voltage-gated channel subfamily H member 6 isoform X1
- Genekcnh6a
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1185 (go to sequence)
- Protein existencePredicted
- Annotation score4/5
Function
Catalytic activity
- K+(in) = K+(out)
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Cellular Component | monoatomic ion channel complex | |
Cellular Component | plasma membrane | |
Molecular Function | inward rectifier potassium channel activity | |
Molecular Function | monoatomic ion channel activity | |
Molecular Function | potassium channel activity | |
Molecular Function | voltage-gated potassium channel activity | |
Biological Process | heart contraction | |
Biological Process | membrane repolarization during cardiac muscle cell action potential | |
Biological Process | potassium ion transmembrane transport | |
Biological Process | regulation of heart contraction | |
Biological Process | regulation of heart rate by cardiac conduction | |
Biological Process | regulation of ventricular cardiac muscle cell membrane repolarization |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionA0A8M2BBD6
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 372-396 | Helical | ||||
Sequence: VWDWIILLLVLYTAVFTPYSAAFLL | ||||||
Transmembrane | 512-538 | Helical | ||||
Sequence: YGAAVLFLLMCTFALIAHWLACIWYAI | ||||||
Transmembrane | 583-599 | Helical | ||||
Sequence: YVTALYFTFSSLTSVGF | ||||||
Transmembrane | 611-635 | Helical | ||||
Sequence: IFSICVMLIGSLMYASIFGNVSAII |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 213-256 | Disordered | ||||
Sequence: ALIQQTPSSCELSPPPSRPSDRLEPSGPLLKHSHSRESMHSLRR | ||||||
Compositional bias | 237-256 | Basic and acidic residues | ||||
Sequence: PSGPLLKHSHSRESMHSLRR | ||||||
Domain | 714-814 | Cyclic nucleotide-binding | ||||
Sequence: AFRGASKGCLRALAMRFRTTHAPPGDTLVHSGDVLTALYFISRGSIEILRDDVVVAILGKNDIFGEPISLYARPGKSSADVRALTYCDLHKILRDDLLEVL | ||||||
Region | 845-875 | Disordered | ||||
Sequence: PSEDSDCGYRRPRHRRNPLRRNRPDGMDRDG | ||||||
Region | 1052-1185 | Disordered | ||||
Sequence: PAYSAVSPDPLAHPAPPAHPTSLYTTAAHNTTPSLQITDASSPGKSPDVDSLKEKSPDSLSSGIHLTVASTDTMSMSPETELSVPSAGPLLQPPGLLCSSLRFPSLPDSLEGPGTLEGSPEIQRHVSDPVLPGS | ||||||
Compositional bias | 1054-1068 | Pro residues | ||||
Sequence: YSAVSPDPLAHPAPP | ||||||
Compositional bias | 1074-1096 | Polar residues | ||||
Sequence: LYTTAAHNTTPSLQITDASSPGK | ||||||
Compositional bias | 1107-1133 | Polar residues | ||||
Sequence: SPDSLSSGIHLTVASTDTMSMSPETEL |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,185
- Mass (Da)132,198
- Last updated2022-08-03 v1
- Checksum35425945AAF00F70
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q8JH78 | Q8JH78_DANRE | kcnh6a | 1186 | ||
A0A8M3AQY1 | A0A8M3AQY1_DANRE | kcnh6a | 856 | ||
A0A8M2BBB6 | A0A8M2BBB6_DANRE | kcnh6a | 915 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 237-256 | Basic and acidic residues | ||||
Sequence: PSGPLLKHSHSRESMHSLRR | ||||||
Compositional bias | 1054-1068 | Pro residues | ||||
Sequence: YSAVSPDPLAHPAPP | ||||||
Compositional bias | 1074-1096 | Polar residues | ||||
Sequence: LYTTAAHNTTPSLQITDASSPGK | ||||||
Compositional bias | 1107-1133 | Polar residues | ||||
Sequence: SPDSLSSGIHLTVASTDTMSMSPETEL |
Keywords
- Technical term