A0A8M2BA12 · A0A8M2BA12_DANRE

Function

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Features

Showing features for binding site, active site.

113351002003004005006007008009001,0001,1001,2001,300
TypeIDPosition(s)Description
Binding site1038-1046ATP (UniProtKB | ChEBI)
Binding site1064ATP (UniProtKB | ChEBI)
Binding site1111-1114ATP (UniProtKB | ChEBI)
Active site1158Proton acceptor
Binding site1162ATP (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentbasal plasma membrane
Cellular Componentplasma membrane
Cellular Componentreceptor complex
Molecular FunctionATP binding
Molecular Functionhepatocyte growth factor receptor activity
Molecular Functionsemaphorin receptor activity
Biological Processaxon guidance
Biological Processcell migration
Biological Processcentral nervous system neuron differentiation
Biological Processcerebellar granule cell differentiation
Biological Processcerebellum development
Biological Processcerebellum morphogenesis
Biological Processcranial nerve formation
Biological Processexocrine pancreas development
Biological Processglial cell migration
Biological Processliver development
Biological Processmuscle cell migration
Biological Processnervous system development
Biological Processneuron differentiation
Biological Processneuron migration
Biological Processpancreas development
Biological Processpectoral fin development
Biological Processphagocytosis
Biological Processprotein phosphorylation
Biological Processspinal cord motor neuron differentiation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Hepatocyte growth factor receptor
  • EC number
  • Alternative names
    • HGF/SF receptor
    • Proto-oncogene c-Met
    • Scatter factor receptor
    • Tyrosine-protein kinase Met

Gene names

    • Name
      met
    • Synonyms
      c-met
      , cmet

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    A0A8M2BA12

Proteomes

Organism-specific databases

Subcellular Location

Membrane
; Single-pass type I membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane932-954Helical

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, modified residue.

TypeIDPosition(s)Description
Signal1-24
ChainPRO_503546035125-1335Hepatocyte growth factor receptor
Disulfide bond104↔155
Disulfide bond131↔139
Disulfide bond168↔171
Disulfide bond294↔359
Disulfide bond515↔533
Disulfide bond521↔558
Disulfide bond524↔542
Disulfide bond536↔548
Modified residue1188Phosphotyrosine; by autocatalysis
Modified residue1189Phosphotyrosine; by autocatalysis
Modified residue1303Phosphotyrosine; by autocatalysis
Modified residue1310Phosphotyrosine; by autocatalysis

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain27-510Sema
Domain1032-1295Protein kinase

Sequence similarities

Belongs to the plexin family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,335
  • Mass (Da)
    148,831
  • Last updated
    2022-08-03 v1
  • Checksum
    9A68E813460D3351
MTIHYSEAASILIILQSLWWGLNCQCEEPIESSKLDLSVTYDLPYFVSDTPIQKLLEINGTVYVGAVNRLYALSKDLKKKHEYKTGPVHEGPDCKTPTDQCSGCENKPRNINNTNMALLMETFYDLELFSCGSVGNGVCSRHVLEDGPLGAEVTCMYTKKNEGSSHGCPDCLAGPAGTQILNIMSGRVVRFFVANSEPLESNGPRLHHTISIRKMRETQDGFEFFSDQSYMDLAPSLRGNYPLHYVYSFQSGPYVYFLTVQREGGNSKAFHTRIVRMCSSDSEILRYVEMPFECIYSERRRKKRSAQVVFNVLQAAHVAKVGYDFQQEMGLKEGEDVLFAAFARSKPDSPEPTASSAVCLISITDINEFFKVFIQKGYTRKLHHFPGSEEKTFNQTFVGDSFSCGKHERGYRLEVTSTNPRRDYFHGRFRNVLLTSIAVVPIQNHTVVSLGTAEGRVIQVVVSRFGKTEPHVDFRLDTLPVSSEMALLSPQHHNGSLLLITGNKVSKLPVIGPGCEQLWTCSSCLLAPGFMGCGWCRTSNLCTRAPRCPQSQWIQDSCPLLITSISPSSAPLRGQTNITICGKNFGFNKKDRFDTKLIDVVVAGTKCKLERKDSNNNRLVCGLDHVNWSSVDSVVTVRSGKEQAQKDGFSFVNPVIIEIFPEFGPQSGGTMLTISGSFLDSGNVQTVTVGNATCVLQSVSATMLTCRTPPQPSPSQHKVQLHIDGVIFEAPVSYTYNKNPHISSVQPKHSFISGGSTVTVNGFYLHSALQPQMVLTAATEGKLFQVTCSHDEDKRNILCITPSLKGLSVQPPVATKMTFVLDGFSTDQYDLLYVEDPKFEEFQKPTVTPRGKKNILEIKVPPVNQEAVKNGEVLRVSNRTCESVTLVGNTLECTVPMELQTAAKELEVEWKQATSSVILGRVILAQDQDYRILITGGVCVSILLLLLIAVFVWIKRKKHINDQNLPLSQTESCRPHLYAHSHVDLSPMLGPMEGDLASPLLPSTAPIDLGSLHPELLKEVQHVVIAREDLLLHVNEIIGRGHFGCVFHGTLLEPDGQKQHCAIKSLNRITDIEEVSQFLKEGIIMKDFSHPNVLSLLGICLPSEGSPLVVLPYMKHGDLRNFIRDESHNPTVKDLMGFGLQVAKGMEYLASKKFVHRDLAARNCMLDESYTVKVADFGLARDVYDKEYYSVHNKHGVKLPVKWMALESLQTHKFTTKSDVWSFGVLLWELMTRGAPPYSDVNSFDITVFLLQGRRLLQPEFCPDALYNVMIECWHPKPERRPTFSELVSRISAIFSSFSGEHYILLNTTYVNIDKMTPYPSLISSQSNLDRDCCT

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
F1QLR7F1QLR7_DANREmet1382
Q64GK4Q64GK4_DANREmet1382

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

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