Essential maintenance is planned to begin on Fri Jan 24 2025. The website may be temporarily unavailable. Please use our fallback: https://wwwdev.ebi.ac.uk/uniprot/front-end/fallback/ in case of any outage.

A0A8M2B7K7 · A0A8M2B7K7_DANRE

Function

Catalytic activity

  • [E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine.
    EC:2.3.2.31 (UniProtKB | ENZYME | Rhea)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentmembrane
Cellular Componentubiquitin ligase complex
Molecular Functionubiquitin conjugating enzyme binding
Molecular Functionubiquitin protein ligase activity
Molecular Functionzinc ion binding
Biological Processprotein polyubiquitination
Biological Processubiquitin-dependent protein catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    RBR-type E3 ubiquitin transferase
  • EC number

Gene names

    • Name
      si:ch211-278j3.3

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    A0A8M2B7K7

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane340-372Helical
Transmembrane393-426Helical

Keywords

  • Cellular component

Family & Domains

Features

Showing features for compositional bias, region, domain.

Type
IDPosition(s)Description
Compositional bias1-16Polar residues
Region1-34Disordered
Domain108-330RING-type
Domain112-159RING-type
Region499-519Disordered
Compositional bias571-596Polar residues
Region571-604Disordered

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    604
  • Mass (Da)
    65,671
  • Last updated
    2022-08-03 v1
  • MD5 Checksum
    519E4F659F38F8C6E70CEB731238B52F
MKRPKQQSQALSFLSFFSRKPKSDPRIEKPTGTLNKEEVAITLTPSEHEHVEQAQGDAGLEVCRFGGDGGTGEGSVVGDEEGAVECGSSGSMAVLSLSSSSQEQLLEHLVECPLCLLSQPRAHFPRLSSCQHRACTDCLRQYLRIEISESRVGIACPQCPEALALPDVRAILDDGALLERFEEFQLRRFLAADPDTRWCPAPDCSYAVIAYGCAECPKLSCGREGCETEFCYHCRQLWHPDQTCDQARRQRARHTSGANDVSTLYVFNEEPGDAEEIKPCPRCGAYIMKTNDGSCNRMNCTVCACQFCWLCMQEITDVHYLSPSGCTFWGKKPWSQTRKVLWQVGMLLGAPVVISLIAGIAIPVIIVGIPIYMGRKVHGRCKKNNTSGSKHYLTVASGVMMSVFVSPVIAAITVGVGVPLMLTYVYGVVPMSLCRNGWCRPQSEPPEVRNIQLEDLANFSDHWTGQNNPALTDASVQEVSVNVEEVMALPSLSVLQSGAAGSAEASDDGHVDSTEPIAQSDEVDVVEECAFSSSQTFALREGTNIEVRVEIEAQPRGARKPSLSSILSSKSLSAESLSQSHEPLCASKQTGSTEPIPVPEIDSV

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
F1R3T6F1R3T6_DANREsi:ch211-278j3.3611

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-16Polar residues
Compositional bias571-596Polar residues

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help