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A0A8M2B4Q8 · A0A8M2B4Q8_DANRE

Function

function

Coenzyme A-dependent lysophosphatidic acid acyltransferase that catalyzes the transfer of an acyl group on a lysophosphatidic acid. Functions preferentially with 1-oleoyl-lysophosphatidic acid followed by 1-palmitoyl-lysophosphatidic acid, 1-stearoyl-lysophosphatidic acid and 1-arachidonoyl-lysophosphatidic acid as lipid acceptor. Functions preferentially with arachidonoyl-CoA followed by oleoyl-CoA as acyl group donors. Functions in phosphatidic acid biosynthesis. May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2. Involved in keratinocyte differentiation. Regulates lipid droplet fusion.

Catalytic activity

  • 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-(9Z)-octadecenoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CoA
    This reaction proceeds in the forward direction.
  • 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphate + CoA
    This reaction proceeds in the forward direction.
  • 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA
    This reaction proceeds in the forward direction.
  • 1-octadecanoyl-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA
    This reaction proceeds in the forward direction.
  • eicosanoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-eicosanoyl-sn-glycero-3-phosphate + CoA
    This reaction proceeds in the forward direction.
  • 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-(9Z)-octadecenoyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA
    This reaction proceeds in the forward direction.
  • 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphate + CoA
    This reaction proceeds in the forward direction.
  • a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA
    This reaction proceeds in the forward direction.
    EC:2.3.1.51 (UniProtKB | ENZYME | Rhea)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentmembrane
Molecular Functiontransferase activity
Biological Processphospholipid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    1-acylglycerol-3-phosphate O-acyltransferase ABHD5
  • EC number
  • Alternative names
    • Abhydrolase domain-containing protein 5

Gene names

    • Name
      abhd5a

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    A0A8M2B4Q8

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane12-33Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain99-354AB hydrolase-1

Sequence similarities

Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    371
  • Mass (Da)
    41,728
  • Last updated
    2022-08-03 v1
  • MD5 Checksum
    E891C1569BB1F90F7C6F90B41BD112DE
MAEETVLADTGLAQRALILLGIHSLFYSVFYFLDKKVRSWWSADWLPSWCPTSKDQLKQAEERMLQNIASKLCRQSVHISDKNSLWTLISKGPAENKTPLVLLHGFGGGVGLWALNLDSLSQQRPVYAFDLLGFGQSSRPHFNTDAQEAEIQFVESIEQWREKLGLESMVMVGHNLGGYLAASYAITYPTRVKHLILVEPWGFPERPEPGNQDRPIPVWIKAIGAMLSPFNPLAGLRLAGPLGPTLVQTLRPDFKKKFATMFDDNRVTEYIYHLNVQSPSGETAFKNMTIPYGWAKRPMLQRIGLIHDDIPITVIYGSRSSIDGHSGNSIKEMRPNSHVEIIVIRGAGHYVYADQPEDFNQKILHVCDTIS

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8M1RNV7A0A8M1RNV7_DANREabhd5a344

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

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