A0A8M2B421 · A0A8M2B421_DANRE
- Proteinnitric-oxide synthase (NADPH)
- Genenos2b
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids687 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
Catalytic activity
- H+ + 2 L-arginine + 3 NADPH + 4 O2 = 4 H2O + 2 L-citrulline + 3 NADP+ + 2 nitric oxideThis reaction proceeds in the forward direction.
CHEBI:15378 + 2 CHEBI:32682 + 3 CHEBI:57783 + 4 CHEBI:15379 = 4 CHEBI:15377 + 2 CHEBI:57743 + 3 CHEBI:58349 + 2 CHEBI:16480
Cofactor
Protein has several cofactor binding sites:
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | nucleus | |
Cellular Component | plasma membrane | |
Molecular Function | calmodulin binding | |
Molecular Function | flavin adenine dinucleotide binding | |
Molecular Function | FMN binding | |
Molecular Function | metal ion binding | |
Molecular Function | nitric-oxide synthase activity | |
Biological Process | arginine catabolic process | |
Biological Process | defense response to bacterium | |
Biological Process | inflammatory response | |
Biological Process | inflammatory response to wounding | |
Biological Process | negative regulation of blood pressure | |
Biological Process | nitric oxide biosynthetic process | |
Biological Process | nitric oxide mediated signal transduction | |
Biological Process | response to hormone | |
Biological Process | response to lipopolysaccharide | |
Biological Process | response to wounding | |
Biological Process | swimming behavior |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namenitric-oxide synthase (NADPH)
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionA0A8M2B421
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 96-234 | Flavodoxin-like | ||||
Sequence: CTVLYATETGKSQTFAKKLNGIMNCCFSSRVVCMEDYNVSELEKESLLIVVTSTFGNGDCPGNGESFKKQLLSLKTLRTKVRYCVFGLGSRMYPHFCAFAHALDAMFASLGAIRVSSTGEGDELKGQEESFSSWACTAF | ||||||
Domain | 283-527 | FAD-binding FR-type | ||||
Sequence: KAVVPMKLKRRQNLQSAKSSCATILVELEMEGNTEPLNFTPGDHVGIFAGNSPGLVAGILKHLSNANPINQSLQLEFLSAHADGERWQRDERIPPCSLAQALTYYLDVTSPPSQSLLRKLSKIARQEDHRQHLLALASDFQVYTTWKDFFKPTFLEVLEEFPSLELSAAFLLSQLPLLKPRLYSISSSPDLHPQELHLTVAVISYYTQEGKGPLHFGLCSNWLNTIKEGDTVPCFLHSSDWFHLP |
Sequence similarities
Belongs to the NOS family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length687
- Mass (Da)77,231
- Last updated2022-08-03 v1
- Checksum5FAA4513F9C95F22
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A9JNR5 | A9JNR5_DANRE | nos2b | 1077 | ||
A0A8M3AHD3 | A0A8M3AHD3_DANRE | nos2b | 939 | ||
F1QML0 | F1QML0_DANRE | nos2b | 1077 |
Keywords
- Technical term