A specific role for SynJ1 in autophagosomal and endosomal trafficking is described and evidence that PI(4 5)P2 participates in autophagy in cone photoreceptors is provided.
This protein localized predominantly to cone photoreceptors. Using blastula stage transplantation experiments study demonstrates that rods from mutants lacking SynJ1 develop normally and do not have the pronounced morphological defects detected in cones
Synj1 is critical for retrieval of membrane in order to maintain the quantity timing of fusion and spontaneous release properties of synaptic vesicles at hair-cell ribbon synapses.
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