A0A8M2B1I0 · A0A8M2B1I0_DANRE
- Proteinphosphoinositide 5-phosphatase
- Genesynj1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1609 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
Catalytic activity
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | presynapse | |
Molecular Function | phosphatidylinositol phosphate 4-phosphatase activity | |
Molecular Function | phosphatidylinositol phosphate 5-phosphatase activity | |
Molecular Function | phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity | |
Molecular Function | RNA binding | |
Molecular Function | SH3 domain binding | |
Biological Process | chemical synaptic transmission | |
Biological Process | detection of visible light | |
Biological Process | phosphatidylinositol dephosphorylation | |
Biological Process | retina development in camera-type eye | |
Biological Process | retinal cone cell development | |
Biological Process | synapse organization | |
Biological Process | synaptic vesicle endocytosis | |
Biological Process | vesicle cytoskeletal trafficking |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namephosphoinositide 5-phosphatase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionA0A8M2B1I0
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 119-444 | SAC | ||||
Sequence: VRKVLNSGNFYFAWSSTGVSLDLSLNAHRRIREDTSDNRFFWNQSLHLHLKHYGVNCDDWLLRLMCGGVEIRTIYAGHKQAKACVISRLSSERAGTRFNVRGTNDDGQVANFVETEQIIFLDDKVSSFIQIRGSIPLFWEQPGIQVGSHRVKLSRGFEANAPAFERHFSALKRLYGKQLIINLLGMKEGEHMLSKAFQSHLKASEHSNAVKMLNFDYHQMVKGGKTEKLQTVLKPQISKFVEDCDFFYYSGETGIQRCQSGTIRSNCLDCLDRTNSVQAFIALEMLPKQLEAMGLTEKPQLVARFQEVFRSMWSTNGDSISKIYAG | ||||||
Domain | 896-972 | RRM | ||||
Sequence: GTILVSLCSSGPDDYFDDALIDDLLDKFANFGEVILIRFVEEKMWVTFLEGYSALAALSLSGSTVNGKTIDIRLRSP | ||||||
Region | 1029-1476 | Disordered | ||||
Sequence: QPGAGMDLSASPATSPRTSPCPSPTHGEPAPPIRPSRAPPRTAGPPQGGLSPASIRRELAGSPVDGQPAGAPFSQGLEPKRPPPPRPNAPPARPAPPQRPPPPSGGRSPTPVRKDSAGFAEPLNLEFDLTDNEGQKSPALARADAAGRGQATGPAPGGIPRPIPPRAGVISVTPQARPPPPAHPGAPRPTAEVHPGAPRPSPDNHPGAPRPTAEPQSKPSELPLGPPLTLPGPVRPQMTSPMQPQSVSPVQPPVQPQLPPPIQSQLPPPMQPTLPAPLMPQQAPQTSAGAGAAAAPQPGLASPKPPPRSRSSHALPPESAPAPTTQAKNMNGVQREAQWNLDPFDMLNPQSLFQNTPFTASLSRSSSSSTSTPSPSSSSSTLPSNLSLFSAPDTSSASCLLAPPAPSRSKSQETLRCSPNPFLTDIQPRPNSTNPFTSGLQSSPRRSL | ||||||
Compositional bias | 1045-1074 | Pro residues | ||||
Sequence: RTSPCPSPTHGEPAPPIRPSRAPPRTAGPP | ||||||
Compositional bias | 1105-1136 | Pro residues | ||||
Sequence: LEPKRPPPPRPNAPPARPAPPQRPPPPSGGRS | ||||||
Compositional bias | 1202-1241 | Pro residues | ||||
Sequence: PQARPPPPAHPGAPRPTAEVHPGAPRPSPDNHPGAPRPTA | ||||||
Compositional bias | 1248-1266 | Pro residues | ||||
Sequence: SELPLGPPLTLPGPVRPQM | ||||||
Compositional bias | 1274-1307 | Pro residues | ||||
Sequence: SVSPVQPPVQPQLPPPIQSQLPPPMQPTLPAPLM | ||||||
Compositional bias | 1346-1364 | Polar residues | ||||
Sequence: ESAPAPTTQAKNMNGVQRE | ||||||
Compositional bias | 1372-1476 | Polar residues | ||||
Sequence: FDMLNPQSLFQNTPFTASLSRSSSSSTSTPSPSSSSSTLPSNLSLFSAPDTSSASCLLAPPAPSRSKSQETLRCSPNPFLTDIQPRPNSTNPFTSGLQSSPRRSL | ||||||
Region | 1577-1609 | Disordered | ||||
Sequence: TSAFPAIPPPVPTRTNTSIKNAQLPSRNDFTER | ||||||
Compositional bias | 1589-1609 | Polar residues | ||||
Sequence: TRTNTSIKNAQLPSRNDFTER |
Sequence similarities
Belongs to the synaptojanin family.
In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,609
- Mass (Da)176,046
- Last updated2022-08-03 v1
- Checksum233AFFA05E270492
Computationally mapped potential isoform sequences
There are 12 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8M2B1N6 | A0A8M2B1N6_DANRE | synj1 | 1612 | ||
A0A8M9PTD8 | A0A8M9PTD8_DANRE | synj1 | 1088 | ||
A0A8M2B1I1 | A0A8M2B1I1_DANRE | synj1 | 1570 | ||
A0A8M2B1P0 | A0A8M2B1P0_DANRE | synj1 | 1583 | ||
A0A8M2B211 | A0A8M2B211_DANRE | synj1 | 1596 | ||
A0A8M2B1W8 | A0A8M2B1W8_DANRE | synj1 | 1599 | ||
A0A8M2B1X1 | A0A8M2B1X1_DANRE | synj1 | 1363 | ||
A0A8M2B291 | A0A8M2B291_DANRE | synj1 | 1596 | ||
A0A8M3B662 | A0A8M3B662_DANRE | synj1 | 1583 | ||
A0A8M3B384 | A0A8M3B384_DANRE | synj1 | 1362 | ||
A0A8M3AWP0 | A0A8M3AWP0_DANRE | synj1 | 1604 | ||
E9QHF3 | E9QHF3_DANRE | synj1 | 1308 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1045-1074 | Pro residues | ||||
Sequence: RTSPCPSPTHGEPAPPIRPSRAPPRTAGPP | ||||||
Compositional bias | 1105-1136 | Pro residues | ||||
Sequence: LEPKRPPPPRPNAPPARPAPPQRPPPPSGGRS | ||||||
Compositional bias | 1202-1241 | Pro residues | ||||
Sequence: PQARPPPPAHPGAPRPTAEVHPGAPRPSPDNHPGAPRPTA | ||||||
Compositional bias | 1248-1266 | Pro residues | ||||
Sequence: SELPLGPPLTLPGPVRPQM | ||||||
Compositional bias | 1274-1307 | Pro residues | ||||
Sequence: SVSPVQPPVQPQLPPPIQSQLPPPMQPTLPAPLM | ||||||
Compositional bias | 1346-1364 | Polar residues | ||||
Sequence: ESAPAPTTQAKNMNGVQRE | ||||||
Compositional bias | 1372-1476 | Polar residues | ||||
Sequence: FDMLNPQSLFQNTPFTASLSRSSSSSTSTPSPSSSSSTLPSNLSLFSAPDTSSASCLLAPPAPSRSKSQETLRCSPNPFLTDIQPRPNSTNPFTSGLQSSPRRSL | ||||||
Compositional bias | 1589-1609 | Polar residues | ||||
Sequence: TRTNTSIKNAQLPSRNDFTER |
Keywords
- Technical term