A0A8M1RN98 · A0A8M1RN98_DANRE

Function

Catalytic activity

Cofactor

a divalent metal cation (UniProtKB | Rhea| CHEBI:60240 )

Note: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

Features

Showing features for active site, binding site.

TypeIDPosition(s)Description
Active site228Proton donor
Binding site228-232AMP (UniProtKB | ChEBI)
Binding site232Zn2+ 1 (UniProtKB | ChEBI)
Binding site268Zn2+ 1 (UniProtKB | ChEBI)
Binding site269AMP (UniProtKB | ChEBI)
Binding site269Zn2+ 2 (UniProtKB | ChEBI)
Binding site269Zn2+ 1 (UniProtKB | ChEBI)
Binding site376AMP (UniProtKB | ChEBI)
Binding site376Zn2+ 1 (UniProtKB | ChEBI)
Binding site427AMP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function3',5'-cyclic-nucleotide phosphodiesterase activity
Molecular Functionmetal ion binding
Biological Processsignal transduction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphodiesterase
  • EC number

Gene names

    • Name
      pde1cb

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    A0A8M1RN98

Proteomes

Organism-specific databases

Family & Domains

Features

Showing features for domain, compositional bias, region.

TypeIDPosition(s)Description
Domain151-523PDEase
Compositional bias527-561Basic and acidic residues
Region527-603Disordered
Compositional bias569-603Basic and acidic residues

Sequence similarities

Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    603
  • Mass (Da)
    69,047
  • Last updated
    2022-08-03 v1
  • Checksum
    78C1FA50056E468B
MESPTREIEEFENTSLKYLQPDQIEKIWLRLRGLRKYKKTSQRLRCLVKQLERGEASLVDLKKNLEYAATVLESVYIEETRRLVDTEDELSDIQSDSVPSEVRDWLASTFTRQMGLMLRRTEEKPRFRSIVHAVQAGIFVERMYRRTSNMVGLSYPPNVIAVLKNVDRWSFDVFALNESSGDHALKFIFYELLTRYDLISRFKIPVSALVSFVEALEVGYSKYKNPYHNLIHAADVTQTVHYLLLKTGMVHWMTELEIFAMIFAAAIHDYEHTGTTNNFHIQTRSDAAILYNDRSVLESHHVSASYRLLQDDDEMNILYNLSKDDWREFRALVVEMVLATDMSCHFQQVKAMKNYLQQPEGIDKPKAISLLLHAADISHPAKTWDLHHRWTTSLLEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVVPTFTVLTDMTEKIVTPLIEEATSSGLSGFRSITGGDVKRSSVNSSASDSSSSHNGSLLTVDLKNFKALWNEEVSLNRERWKMQAAKETEEKAKRELEEQQEVENQVQKKELELSEPKKDDPEPGVVNGPPEESPHGKSKKLQNGEVSEEAESPADEDKRTLSETAKP

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8M6YUN9A0A8M6YUN9_DANREpde1cb698
A0A8M3B7Y8A0A8M3B7Y8_DANREpde1cb679

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias527-561Basic and acidic residues
Compositional bias569-603Basic and acidic residues

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

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