A0A8M1RN98 · A0A8M1RN98_DANRE
- ProteinPhosphodiesterase
- Genepde1cb
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids603 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- 3',5'-cyclic AMP + H2O = AMP + H+This reaction proceeds in the forward direction.
- 3',5'-cyclic GMP + H2O = GMP + H+This reaction proceeds in the forward direction.
Cofactor
Note: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 228 | Proton donor | ||||
Sequence: H | ||||||
Binding site | 228-232 | AMP (UniProtKB | ChEBI) | ||||
Sequence: HNLIH | ||||||
Binding site | 232 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 268 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 269 | AMP (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 269 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 269 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 376 | AMP (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 376 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 427 | AMP (UniProtKB | ChEBI) | ||||
Sequence: Q |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 3',5'-cyclic-nucleotide phosphodiesterase activity | |
Molecular Function | metal ion binding | |
Biological Process | signal transduction |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphodiesterase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionA0A8M1RN98
Proteomes
Organism-specific databases
Structure
Family & Domains
Features
Showing features for domain, compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 151-523 | PDEase | ||||
Sequence: VGLSYPPNVIAVLKNVDRWSFDVFALNESSGDHALKFIFYELLTRYDLISRFKIPVSALVSFVEALEVGYSKYKNPYHNLIHAADVTQTVHYLLLKTGMVHWMTELEIFAMIFAAAIHDYEHTGTTNNFHIQTRSDAAILYNDRSVLESHHVSASYRLLQDDDEMNILYNLSKDDWREFRALVVEMVLATDMSCHFQQVKAMKNYLQQPEGIDKPKAISLLLHAADISHPAKTWDLHHRWTTSLLEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVVPTFTVLTDMTEKIVTPLIEEATSSGLSGFRSITGGDVKRSSVNSSASDSSSSHNGSLLTVDLKNFKALWNEEVSLNRERWKMQAAKE | ||||||
Compositional bias | 527-561 | Basic and acidic residues | ||||
Sequence: KAKRELEEQQEVENQVQKKELELSEPKKDDPEPGV | ||||||
Region | 527-603 | Disordered | ||||
Sequence: KAKRELEEQQEVENQVQKKELELSEPKKDDPEPGVVNGPPEESPHGKSKKLQNGEVSEEAESPADEDKRTLSETAKP | ||||||
Compositional bias | 569-603 | Basic and acidic residues | ||||
Sequence: SPHGKSKKLQNGEVSEEAESPADEDKRTLSETAKP |
Sequence similarities
Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length603
- Mass (Da)69,047
- Last updated2022-08-03 v1
- Checksum78C1FA50056E468B
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8M6YUN9 | A0A8M6YUN9_DANRE | pde1cb | 698 | ||
A0A8M3B7Y8 | A0A8M3B7Y8_DANRE | pde1cb | 679 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 527-561 | Basic and acidic residues | ||||
Sequence: KAKRELEEQQEVENQVQKKELELSEPKKDDPEPGV | ||||||
Compositional bias | 569-603 | Basic and acidic residues | ||||
Sequence: SPHGKSKKLQNGEVSEEAESPADEDKRTLSETAKP |
Keywords
- Technical term