A0A8L2UKG8 · A0A8L2UKG8_RAT
- ProteinHistone deacetylase
- GeneHdac4
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1087 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
function
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.
Catalytic activity
- N6-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate
Features
Showing features for binding site, active site, site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 670 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 672 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 678 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 754 | Zn2+ (UniProtKB | ChEBI) | |||
Active site | 806 | ||||
Site | 979 | Contributes to catalysis | |||
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHistone deacetylase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionA0A8L2UKG8
Proteomes
Organism-specific databases
Subcellular Location
Structure
Family & Domains
Features
Showing features for domain, compositional bias, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 62-151 | Histone deacetylase glutamine rich N-terminal | |||
Compositional bias | 132-166 | Basic and acidic residues | |||
Region | 132-167 | Disordered | |||
Compositional bias | 204-224 | Polar residues | |||
Region | 204-225 | Disordered | |||
Compositional bias | 239-278 | Basic and acidic residues | |||
Region | 239-327 | Disordered | |||
Compositional bias | 290-327 | Polar residues | |||
Region | 513-535 | Disordered | |||
Compositional bias | 520-535 | Basic and acidic residues | |||
Region | 547-587 | Disordered | |||
Region | 628-651 | Disordered | |||
Domain | 678-995 | Histone deacetylase | |||
Region | 1062-1087 | Disordered | |||
Compositional bias | 1071-1087 | Basic and acidic residues | |||
Sequence similarities
Belongs to the histone deacetylase family. HD type 2 subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,087
- Mass (Da)119,857
- Last updated2022-08-03 v1
- MD5 Checksum3FEEF6CDE809A763F1569BCE9B3A9BBE
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q99P99 | HDAC4_RAT | Hdac4 | 1077 | ||
A0A8I5ZP14 | A0A8I5ZP14_RAT | Hdac4 | 1072 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 132-166 | Basic and acidic residues | |||
Compositional bias | 204-224 | Polar residues | |||
Compositional bias | 239-278 | Basic and acidic residues | |||
Compositional bias | 290-327 | Polar residues | |||
Compositional bias | 520-535 | Basic and acidic residues | |||
Compositional bias | 1071-1087 | Basic and acidic residues | |||
Keywords
- Technical term