A0A8L2UKG8 · A0A8L2UKG8_RAT

Function

function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

Catalytic activity

Features

Showing features for binding site, active site, site.

110871002003004005006007008009001,000
Type
IDPosition(s)Description
Binding site670Zn2+ (UniProtKB | ChEBI)
Binding site672Zn2+ (UniProtKB | ChEBI)
Binding site678Zn2+ (UniProtKB | ChEBI)
Binding site754Zn2+ (UniProtKB | ChEBI)
Active site806
Site979Contributes to catalysis

GO annotations

AspectTerm
Cellular Componentactomyosin
Cellular Componentcytosol
Cellular Componentneuromuscular junction
Cellular Componentnuclear speck
Molecular Functionchromatin binding
Molecular FunctionDNA binding
Molecular FunctionDNA-binding transcription factor binding
Molecular Functionhistone deacetylase activity
Molecular Functionmetal ion binding
Molecular Functionprotein kinase binding
Molecular Functiontranscription corepressor activity
Biological Processcell population proliferation
Biological Processnegative regulation of cell population proliferation
Biological Processnegative regulation of glycolytic process
Biological Processnegative regulation of miRNA transcription
Biological Processnegative regulation of osteoblast differentiation
Biological Processnegative regulation of transcription by RNA polymerase II
Biological Processosteoblast development
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processregulation of cardiac muscle contraction by calcium ion signaling
Biological Processregulation of skeletal muscle fiber development
Biological Processregulation of skeletal muscle fiber differentiation
Biological Processresponse to denervation involved in regulation of muscle adaptation
Biological Processskeletal system development

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Histone deacetylase
  • EC number

Gene names

    • Name
      Hdac4

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Brown Norway
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    A0A8L2UKG8

Proteomes

Organism-specific databases

Subcellular Location

Keywords

  • Cellular component

Family & Domains

Features

Showing features for domain, compositional bias, region.

Type
IDPosition(s)Description
Domain62-151Histone deacetylase glutamine rich N-terminal
Compositional bias132-166Basic and acidic residues
Region132-167Disordered
Compositional bias204-224Polar residues
Region204-225Disordered
Compositional bias239-278Basic and acidic residues
Region239-327Disordered
Compositional bias290-327Polar residues
Region513-535Disordered
Compositional bias520-535Basic and acidic residues
Region547-587Disordered
Region628-651Disordered
Domain678-995Histone deacetylase
Region1062-1087Disordered
Compositional bias1071-1087Basic and acidic residues

Sequence similarities

Belongs to the histone deacetylase family. HD type 2 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,087
  • Mass (Da)
    119,857
  • Last updated
    2022-08-03 v1
  • MD5 Checksum
    3FEEF6CDE809A763F1569BCE9B3A9BBE
MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVATALPLQVAPAAVPMDLRLDHQFSLPLEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLAMKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFVLNKKKALAHRNLNHCMSSDPRYWYGKTQHSSLDQSSPPQSGVSASYNHPVLGMYDAKDDFPLRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVATALKKRPLDVTDSACSSAPGSGPSSPNSSSGNVSTENGIAPTVPSTPAETSLAHRLVTREGSVAPLPLYTSPSLPNITLGLPATGPAAGAAGQQDAERLALPALQQRISLFPGTHLTPYLSTSPLERDGGAAHNPLLQHMVLLEQPPTQTPLVTDWYLSGLGALPLHTQSLVGADRVSPSIHKLRQHRPLGRTQSAPLPQNAQALQHLVIQQQHQQFLEKHKQQFQQQQLHLSKMISKPSEPPRQPESHPEETEEELREHQALLDEPYLDRLPGQKEPSLAGVQVKQEPIESEEEEVEATREAEPSQRPATEQELLFRQQALLLEQQRIHQLRNYQASMEAAGIPVSFGSHRPLSRAQSSPASATFPMSVQEPPTKPRFTTGLVYDTLMLKHQCTCGNTNSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPLNRQKLDSKKLLGSLTSVFVRLPCGGVGVDSDTIWNEVHSSGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAIAAKLLQQRLNVSKILIVDWDVHHGNGTQQAFYNDPNVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVMPIANEFAPDVVLVSSGFDAVEGHPTPLGGYNLSAKCFGYLTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELEPLPEKVLHQRPNANAVHSMEKVMGIHSEYWRCLQRLSPTVGHSLIEAQKCENEEAETVTAMASLSVGVKPAEKRSEEEPMEEEPPL

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q99P99HDAC4_RATHdac41077
A0A8I5ZP14A0A8I5ZP14_RATHdac41072

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias132-166Basic and acidic residues
Compositional bias204-224Polar residues
Compositional bias239-278Basic and acidic residues
Compositional bias290-327Polar residues
Compositional bias520-535Basic and acidic residues
Compositional bias1071-1087Basic and acidic residues

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

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