A0A8L2UJE9 · A0A8L2UJE9_RAT

Function

function

Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron.

Catalytic activity

Features

Showing features for binding site.

128420406080100120140160180200220240260280
TypeIDPosition(s)Description
Binding site18heme b (UniProtKB | ChEBI)
Binding site25Fe (UniProtKB | ChEBI) of heme b (UniProtKB | ChEBI); axial binding residue
Binding site134heme b (UniProtKB | ChEBI)
Binding site183heme b (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Cellular Componentendoplasmic reticulum membrane
Cellular Componentnucleus
Cellular Componentperinuclear region of cytoplasm
Molecular Functionheme binding
Molecular Functionheme oxygenase (decyclizing) activity
Molecular Functionmetal ion binding
Molecular Functionprotein homodimerization activity
Molecular Functionstructural molecule activity
Biological Processcellular response to arsenic-containing substance
Biological Processcellular response to cadmium ion
Biological Processcellular response to cisplatin
Biological Processcellular response to heat
Biological Processcellular response to hypoxia
Biological Processepithelial cell apoptotic process
Biological Processerythrocyte homeostasis
Biological Processheme catabolic process
Biological Processheme oxidation
Biological Processintracellular iron ion homeostasis
Biological Processmacroautophagy
Biological Processmulticellular organismal-level iron ion homeostasis
Biological Processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
Biological Processnegative regulation of macroautophagy
Biological Processnegative regulation of smooth muscle cell proliferation
Biological Processpositive regulation of angiogenesis
Biological Processpositive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
Biological Processpositive regulation of cell migration involved in sprouting angiogenesis
Biological Processpositive regulation of epithelial cell apoptotic process
Biological Processpositive regulation of macroautophagy
Biological Processpositive regulation of smooth muscle cell proliferation
Biological Processresponse to nicotine
Biological Processresponse to oxidative stress
Biological Processwound healing involved in inflammatory response

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Heme oxygenase
  • EC number

Gene names

    • Name
      Hmox1

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Brown Norway
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    A0A8L2UJE9

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane263-283Helical

Keywords

Structure

3D structure databases

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region225-256Disordered
Compositional bias233-256Polar residues

Sequence similarities

Belongs to the heme oxygenase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    284
  • Mass (Da)
    32,530
  • Last updated
    2022-08-03 v1
  • Checksum
    2EC829A13F3FB645
MERPQLDSMSQDLSEALKEATKEVHIRAENSEFMRNFQKGQVSREGFKLVMASLYHIYTALEEEIERNKQNPVYAPLYFPEELHRRAALEQDMAFWYGPHWQEAIPYTPATQHYVKRLHEVGGTHPELLVAHAYTRYLGDLSGGQVLKKIAQKAMALPSSGEGLAFFTFPSIDNPTKFKQLYRARMNTLEMTPEVKHRVTEEAKTAFLLNIELFEELQALLTEEHKDQSPSQTEFLRQRPASLVQETPRGKSQISTSSSQTPLLRWVLTLSFLLATVAVGIYAM

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
P06762HMOX1_RATHmox1289

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias233-256Polar residues

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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