A0A8L2R913 · A0A8L2R913_RAT

  • Protein
    Cellular tumor antigen p53
  • Gene
    Tp53
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence. Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Negatively regulates cell division by controlling expression of a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for site, binding site.

138550100150200250300350
Type
IDPosition(s)Description
Site118Interaction with DNA
Binding site174Zn2+ (UniProtKB | ChEBI)
Binding site177Zn2+ (UniProtKB | ChEBI)
Binding site234Zn2+ (UniProtKB | ChEBI)
Binding site238Zn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum
Cellular Componentmitochondrial matrix
Cellular ComponentPML body
Molecular FunctionDNA-binding transcription factor activity
Molecular Functionmetal ion binding
Molecular Functiontranscription cis-regulatory region binding
Biological Processapoptotic process
Biological Processprotein tetramerization
Biological Processrhythmic process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cellular tumor antigen p53

Gene names

    • Name
      Tp53

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Brown Norway
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    A0A8L2R913

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for cross-link.

TypeIDPosition(s)Description
Cross-link287Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)

Keywords

Interaction

Subunit

Binds DNA as a homotetramer.

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain6-29p53 transactivation
Region65-90Disordered
Domain98-284p53 DNA-binding
Compositional bias279-294Basic and acidic residues
Region279-318Disordered
Compositional bias298-312Polar residues
Domain311-348p53 tetramerisation
Compositional bias344-360Basic and acidic residues
Region344-385Disordered

Sequence similarities

Belongs to the p53 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    385
  • Mass (Da)
    42,866
  • Last updated
    2022-08-03 v1
  • Checksum
    16F709DC5F96ED99
MEDSQSDMSIELPLSQETFSCLWKLLPPDDILPTTATGSPNSMEDLFLPQDVAELLEGPEEALQVSAPAAQEPGTEAPAPVAPASATPWPLSSSVPSQKTYQGNYGFHLGFLQSGTAKSVMCTYSISLNKLFCQLAKTCPVQLWVTSTPPPGTRVRAMAIYKKSQHMTEVVRRCPHHERCSDGLAPPQHLIRVEGNPYAEYLDDRQTFRHSVVVPYEPPEVGSDYTTIHYKYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRDSFEVRVCACPGRDRRTEEENFRKKEEHCPELPPGTLPTSTSSSPQQKKKPLDGEYFTLKIRGRERFEMFRELNEALELKDARAAEESGDSRAHSSYPKTKKGQSTSRHKKPMIKKVGPDSD

Computationally mapped potential isoform sequences

There are 7 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
P10361P53_RATTp53391
A0A0G2JTP9A0A0G2JTP9_RATTp53265
A0A0G2KB75A0A0G2KB75_RATTp53174
A0A0G2KBB2A0A0G2KBB2_RATTp53386
A0A8I6AAP4A0A8I6AAP4_RATTp53390
A0A8I6AEF4A0A8I6AEF4_RATTp53406
A0A8I5ZQW3A0A8I5ZQW3_RATTp53364

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias279-294Basic and acidic residues
Compositional bias298-312Polar residues
Compositional bias344-360Basic and acidic residues

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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