A0A8L2R4U0 · A0A8L2R4U0_RAT

  • Protein
    7-dehydrocholesterol reductase
  • Gene
    Dhcr7
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

Catalyzes the last step of the cholesterol synthesis pathway, which transforms cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol,7-DHC) into cholesterol by reducing the C7-C8 double bond of its sterol core. Can also metabolize cholesta-5,7,24-trien-3beta-ol (7-dehydrodemosterol, 7-DHD) to desmosterol, which is then metabolized by the Delta24-sterol reductase (DHCR24) to cholesterol. Modulates ferroptosis (a form of regulated cell death driven by iron-dependent lipid peroxidation) through the metabolic breakdown of the anti-ferroptotic metabolites 7-DHC and 7-DHD which, when accumulated, divert the propagation of peroxyl radical-mediated damage from phospholipid components to its sterol core, protecting plasma and mitochondrial membranes from phospholipid autoxidation.

Catalytic activity

Pathway

Steroid biosynthesis; cholesterol biosynthesis.

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Cellular Componentnuclear outer membrane
Molecular Function7-dehydrocholesterol reductase activity
Biological Processcholesterol biosynthetic process via lathosterol
Biological Processpositive regulation of ferroptosis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    7-dehydrocholesterol reductase
  • EC number
  • Short names
    7-DHC
  • Alternative names
    • Sterol Delta(7)-reductase

Gene names

    • Name
      Dhcr7

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Brown Norway
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    A0A8L2R4U0

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane36-57Helical
Transmembrane147-164Helical
Transmembrane176-196Helical
Transmembrane236-254Helical
Transmembrane261-281Helical
Transmembrane301-319Helical
Transmembrane331-350Helical
Transmembrane414-439Helical

Keywords

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-21Disordered

Sequence similarities

Belongs to the ERG4/ERG24 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    474
  • Mass (Da)
    54,513
  • Last updated
    2022-08-03 v1
  • Checksum
    93543A972DD37C16
MILMASKSQHNASKAKNHNVKAESQGQWGRAWEVDWFSLVSVIFLLLFAPFIVYYFIMACDQYSCSLTAPILDVATGRASLADIWAKTPPVTAKAAQLYALWVSFQVLLYSWLPDFCHRFLPGYVGGVQEGAITPAGIVNKYEVNGLQAWLITHFLWFVNAYLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMIKGYLFPTSAEDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQQELYGHVTNSMILVNVLQAIYVLDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPNALGVLLLGLVGYYIFRMTNHQKDLFRRTDGHCLIWGKKPKAIECSYTSADGLKHRSKLLVSGFWGVARHFNYTGDLMGSLAYCLACGGGHLLPYFYIIYMTILLTHRCLRDEHRCANKYGRDWERYVAAVPYRLLPGIF

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
Q9Z2Z8DHCR7_RATDhcr7471

Keywords

Genome annotation databases

Similar Proteins

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