A0A8L2R4U0 · A0A8L2R4U0_RAT
- Protein7-dehydrocholesterol reductase
- GeneDhcr7
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids474 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Catalyzes the last step of the cholesterol synthesis pathway, which transforms cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol,7-DHC) into cholesterol by reducing the C7-C8 double bond of its sterol core. Can also metabolize cholesta-5,7,24-trien-3beta-ol (7-dehydrodemosterol, 7-DHD) to desmosterol, which is then metabolized by the Delta24-sterol reductase (DHCR24) to cholesterol. Modulates ferroptosis (a form of regulated cell death driven by iron-dependent lipid peroxidation) through the metabolic breakdown of the anti-ferroptotic metabolites 7-DHC and 7-DHD which, when accumulated, divert the propagation of peroxyl radical-mediated damage from phospholipid components to its sterol core, protecting plasma and mitochondrial membranes from phospholipid autoxidation.
Catalytic activity
- 7-dehydrodesmosterol + NADPH + H+ = desmosterol + NADP+This reaction proceeds in the forward direction.
Pathway
Steroid biosynthesis; cholesterol biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Cellular Component | nuclear outer membrane | |
Molecular Function | 7-dehydrocholesterol reductase activity | |
Biological Process | cholesterol biosynthetic process via lathosterol | |
Biological Process | positive regulation of ferroptosis |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name7-dehydrocholesterol reductase
- EC number
- Short names7-DHC
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionA0A8L2R4U0
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 36-57 | Helical | ||||
Sequence: WFSLVSVIFLLLFAPFIVYYFI | ||||||
Transmembrane | 147-164 | Helical | ||||
Sequence: LQAWLITHFLWFVNAYLL | ||||||
Transmembrane | 176-196 | Helical | ||||
Sequence: WIPLLWCANILGYAVSTFAMI | ||||||
Transmembrane | 236-254 | Helical | ||||
Sequence: LFFNGRPGIVAWTLINLSF | ||||||
Transmembrane | 261-281 | Helical | ||||
Sequence: LYGHVTNSMILVNVLQAIYVL | ||||||
Transmembrane | 301-319 | Helical | ||||
Sequence: FGWYLGWGDCVWLPYLYTL | ||||||
Transmembrane | 331-350 | Helical | ||||
Sequence: LSTPNALGVLLLGLVGYYIF | ||||||
Transmembrane | 414-439 | Helical | ||||
Sequence: SLAYCLACGGGHLLPYFYIIYMTILL |
Keywords
- Cellular component
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length474
- Mass (Da)54,513
- Last updated2022-08-03 v1
- Checksum93543A972DD37C16
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q9Z2Z8 | DHCR7_RAT | Dhcr7 | 471 |
Keywords
- Technical term